Kitl - kit ligand Gene

Also Known as Gb; SF; Sl; Clo; Con; Mgf; SCF; SLF; blz; Kitlg; contrasted

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17311

Summary

Enables cytokine activity and stem cell factor receptor binding activity. Acts upstream of or within several processes, including positive regulation of cell differentiation; positive regulation of cell population proliferation; and positive regulation of protein phosphorylation. Located in extracellular space and plasma membrane. Is integral component of membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 69 and familial progressive hyperpigmentation with or without hypopigmentation. Orthologous to human KITLG (KIT ligand). [provided by Alliance of Genome Resources, Apr 2022]

Kitl Products (2)

mRNA Protein Name
NM_001347156.1 NP_001334085.1 kit ligand isoform 2 precursor
NM_013598.3 NP_038626.1 kit ligand isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cytokine activity IDA
IDA: Inferred from direct assay
12714518 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
1698557 MGI
enables stem cell factor receptor binding IDA
IDA: Inferred from direct assay
10872802 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of Ras protein signal transduction IDA
IDA: Inferred from direct assay
11435472 MGI
acts upstream of T cell proliferation IDA
IDA: Inferred from direct assay
15947484 MGI
acts upstream of apoptotic process IGI
IGI: Inferred from genetic interaction
17107997 MGI
acts upstream of cell population proliferation IDA
IDA: Inferred from direct assay
11401406 MGI
acts upstream of cell population proliferation IGI
IGI: Inferred from genetic interaction
7690439 MGI
acts upstream of or within ectopic germ cell programmed cell death IMP
IMP: Inferred from mutant phenotype
17107997 MGI
acts upstream of or within extrinsic apoptotic signaling pathway in absence of ligand IDA
IDA: Inferred from direct assay
15039234 MGI
acts upstream of hematopoietic progenitor cell differentiation IGI
IGI: Inferred from genetic interaction
1375116 MGI
acts upstream of mast cell apoptotic process IDA
IDA: Inferred from direct assay
12714518 MGI
acts upstream of mast cell migration IDA
IDA: Inferred from direct assay
24068671 MGI
acts upstream of mast cell proliferation IDA
IDA: Inferred from direct assay
11435472 MGI
acts upstream of mast cell proliferation IGI
IGI: Inferred from genetic interaction
10620616 MGI
acts upstream of or within melanocyte migration IDA
IDA: Inferred from direct assay
11401406 MGI
acts upstream of myeloid leukocyte differentiation IGI
IGI: Inferred from genetic interaction
1375116 MGI
acts upstream of or within negative regulation of apoptotic process IGI
IGI: Inferred from genetic interaction
17107997 MGI
acts upstream of or within negative regulation of mast cell apoptotic process IDA
IDA: Inferred from direct assay
12714518 MGI
acts upstream of or within neural crest cell migration IDA
IDA: Inferred from direct assay
11401406 MGI
acts upstream of peptidyl-tyrosine phosphorylation IDA
IDA: Inferred from direct assay
10872802 MGI
acts upstream of or within positive regulation of MAP kinase activity IGI
IGI: Inferred from genetic interaction
10620616 MGI
acts upstream of or within positive regulation of Ras protein signal transduction IDA
IDA: Inferred from direct assay
11435472 MGI
acts upstream of or within positive regulation of T cell proliferation IDA
IDA: Inferred from direct assay
15947484 MGI
acts upstream of or within positive regulation of cell population proliferation IDA
IDA: Inferred from direct assay
11401406 MGI
acts upstream of or within positive regulation of cell population proliferation IGI
IGI: Inferred from genetic interaction
7690439 MGI
acts upstream of or within positive regulation of hematopoietic progenitor cell differentiation IGI
IGI: Inferred from genetic interaction
1375116 MGI
acts upstream of or within positive regulation of hematopoietic stem cell proliferation IDA
IDA: Inferred from direct assay
21540074 MGI
acts upstream of or within positive regulation of leukocyte migration IDA
IDA: Inferred from direct assay
24068671 MGI
acts upstream of or within positive regulation of mast cell proliferation IDA
IDA: Inferred from direct assay
11435472 MGI
acts upstream of or within positive regulation of mast cell proliferation IGI
IGI: Inferred from genetic interaction
10620616 MGI
acts upstream of or within positive regulation of melanocyte differentiation IDA
IDA: Inferred from direct assay
16427619 MGI
acts upstream of or within positive regulation of myeloid leukocyte differentiation IGI
IGI: Inferred from genetic interaction
1375116 MGI
acts upstream of or within positive regulation of peptidyl-tyrosine phosphorylation IDA
IDA: Inferred from direct assay
10872802 MGI
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
7690439 MGI
located in membrane IDA
IDA: Inferred from direct assay
12140361 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
14525951 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

kit ligand

  • C-kit ligand

  • Steel factor

  • cloud gray

  • grizzle-belly

  • hematopoietic growth factor KL

  • mast cell growth factor

  • stem cell factor

Recombinant Kitl Proteins

Cat. No. Product Name Accession Purity
HY-P7064 SCF Protein, Mouse (P.pastoris) P20826 (K26-A189) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P70528 SCF Protein, Mouse P20826 (K26-A189) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P70555 SCF Protein, Mouse (HEK293, His) P20826 (K26-A189) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P73662 SCF Protein, Mouse (sf9, His) P20826 (K26-A189) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P77529 SCF Protein, Mouse (Biotinylated, sf9, His) P20826 (K26-A189) ≥ 80%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07322 KITLG Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23875 Kitlg Rat Pre-designed siRNA Set A Pre-designed Set / Unkown