2. Gene
  3. Mknk2 - MAP kinase-interacting serine/threonine kinase 2 Gene

Mknk2 - MAP kinase-interacting serine/threonine kinase 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Mnk2; Gprk7; 2010016G11Rik

Gene ID: 17347 | Gene type: protein coding

About Mknk2

Chromosome 10: 80,501,161-80,513,946 reverse strand.GRCm39:CM001003.3

This gene has 5 transcripts (splice variants), 224 orthologues, 6 paralogues and is associated with 1 phenotype. Broad expression in mammary gland adult (RPKM 326.2), subcutaneous fat pad adult (RPKM 252.6) and 25 other tissues.

Summary

The protein encoded by this gene is a serine/threonine-protein kinase, which is targeted by both the extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways. This Enzyme targets several substrates including eukaryotic translation initiation factor 4E and mammalian target of rapamycin, which are negatively regulated by its phosphorylation. Null mutant mice do not exhibit developmental or reproductive defects. However, mice null for both this protein and mitogen-activated protein kinase-interacting serine/threonine protein kinase 1 have delayed tumor development in Phosphatase and tensin homolog mutant mice, indicating an oncogenic function for this gene in tumor development. [provided by RefSeq, Oct 2014]

Mknk2 Products(1)

mRNA Protein Name
NM_021462.4 NP_067437.2 MAP kinase-interacting serine/threonine-protein kinase 2

Mknk2 Protein Structure

PKc_like

PKc_like: cl21453 (80 - 367)

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  • 459 a.a.
Protein Preferred Names Protein Names

MAP kinase-interacting serine/threonine-protein kinase 2

G protein-coupled receptor kinase 7

MAP kinase signal-integrating kinase 2

Related Agents

Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-136848 SM1-71 Inhibitor 96.00% Unkown
HY-148062 RSS0680 98.03% Unkown
HY-RS08476 MKNK2 Human Pre-designed siRNA Set A / Unkown
HY-RS08477 Mknk2 Mouse Pre-designed siRNA Set A / Unkown
HY-RS08478 Mknk2 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mknk2 NCBI NCBI:2872