Mknk2 - MAP kinase-interacting serine/threonine kinase 2 Gene

Also Known as Mnk2; Gprk7; 2010016G11Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 17347

About Mknk2

Chromosome 10: 80,501,161-80,513,946 reverse strand.GRCm39:CM001003.3

This gene has 5 transcripts (splice variants), 224 orthologues, 6 paralogues and is associated with 1 phenotype. Broad expression in mammary gland adult (RPKM 326.2), subcutaneous fat pad adult (RPKM 252.6) and 25 other tissues.

Summary

The protein encoded by this gene is a serine/threonine-protein kinase, which is targeted by both the extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways. This enzyme targets several substrates including eukaryotic translation initiation factor 4E and mammalian target of rapamycin, which are negatively regulated by its phosphorylation. Null mutant mice do not exhibit developmental or reproductive defects. However, mice null for both this protein and mitogen-activated protein kinase-interacting serine/threonine protein kinase 1 have delayed tumor development in Phosphatase and tensin homolog mutant mice, indicating an oncogenic function for this gene in tumor development. [provided by RefSeq, Oct 2014]

Mknk2 Products (1)

mRNA	Protein	Name
NM_021462.4	NP_067437.2	MAP kinase-interacting serine/threonine-protein kinase 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables ATP binding	IDA IDA: Inferred from direct assay	9155017	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	15102471	MGI
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	9155017	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within extrinsic apoptotic signaling pathway in absence of ligand	IGI IGI: Inferred from genetic interaction	17903173	MGI
acts upstream of or within extrinsic apoptotic signaling pathway in absence of ligand	IMP IMP: Inferred from mutant phenotype	17903173	MGI
involved in intracellular signal transduction	IDA IDA: Inferred from direct assay	9155017	MGI
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	9155017	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Mknk2 Protein Structure

PKc_like

0
100
200
300
400
459 a.a.

Protein Preferred Names	Protein Names
MAP kinase-interacting serine/threonine-protein kinase 2	G protein-coupled receptor kinase 7 MAP kinase signal-integrating kinase 2

Mknk2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Mknk2	Q8CDB0	Mapk1	Mus musculus	P63085	Y2H	15102471

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-136848	SM1-71	Inhibitor	96.09%	Unkown
HY-148062	RSS0680	Degrader	98.03%	Unkown
HY-121723	PU-H39	Inhibitor	/	Unkown
HY-RS08476	MKNK2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS08477	Mknk2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS08478	Mknk2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mknk2	NCBI	NCBI:2872