Ncam1 - neural cell adhesion molecule 1 Gene

Also Known as CD56; Ncam; E-NCAM; NCAM-1

Species: Mus musculus

Gene Type: protein coding

Gene ID: 17967

Summary

Predicted to enable LRR domain binding activity and Phosphatase binding activity. Involved in commissural neuron axon guidance and regulation of semaphorin-plexin signaling pathway. Acts upstream of or within several processes, including homotypic cell-cell adhesion; positive regulation of calcium-mediated signaling; and regulation of exocyst assembly. Located in several cellular components, including external side of plasma membrane; growth cone; and neuronal cell body. Is expressed in several structures, including embryo mesenchyme; nervous system; sensory organ; skin; and urinary system. Human ortholog(s) of this gene implicated in bipolar disorder; middle cerebral artery infarction; and pancreatic Cancer. Orthologous to human NCAM1 (neural cell adhesion molecule 1). [provided by Alliance of Genome Resources, Apr 2022]

Ncam1 Products (5)

mRNA	Protein	Name
NM_001081445.2	NP_001074914.1	neural cell adhesion molecule 1 isoform 1 precursor
NM_001113204.2	NP_001106675.1	neural cell adhesion molecule 1 isoform 3 precursor
NM_001311065.2	NP_001297994.1	neural cell adhesion molecule 1 isoform 4 precursor
NM_001404722.1	NP_001391651.1	neural cell adhesion molecule 1 isoform 5 precursor
NM_010875.4	NP_035005.2	neural cell adhesion molecule 1 isoform 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10772929	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of calcium-mediated signaling	IDA IDA: Inferred from direct assay	7613634	MGI
acts upstream of or within cell surface receptor signaling pathway	IDA IDA: Inferred from direct assay	7613634	MGI
involved in commissural neuron axon guidance	IGI IGI: Inferred from genetic interaction	22998873	MGI
involved in epithelial to mesenchymal transition	IDA IDA: Inferred from direct assay	28098160	MGI
acts upstream of or within homotypic cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	7613634	MGI
acts upstream of or within neuron projection development	IGI IGI: Inferred from genetic interaction	21389209	MGI
acts upstream of or within positive regulation of calcium-mediated signaling	IDA IDA: Inferred from direct assay	7613634	MGI
acts upstream of or within regulation of exocyst assembly	IMP IMP: Inferred from mutant phenotype	21389209	MGI
involved in regulation of semaphorin-plexin signaling pathway	IGI IGI: Inferred from genetic interaction	22998873	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in axon	IDA IDA: Inferred from direct assay	15065125	MGI
located in cell-cell junction	IDA IDA: Inferred from direct assay	23284756	MGI
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	7613634	MGI
located in growth cone	IDA IDA: Inferred from direct assay	21389209	MGI
located in neuronal cell body	IDA IDA: Inferred from direct assay	15065125	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
neural cell adhesion molecule 1	N-CAM-1

Recombinant Ncam1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P78764	NCAM-1/CD56 Protein, Mouse (HEK293, His)	P13595 (L20-T711)	≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99372	Lorvotuzumab		99.77%	Phase 2

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09063	NCAM1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17707	Ncam1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24172	Ncam1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ncam1	NCBI	NCBI:4684