NCAM1 - neural cell adhesion molecule 1 Gene

Also Known as CD56; NCAM; MSK39

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4684

About NCAM1

Cytogenetic location: 11q23.2 Genomic coordinates (GRCh38): 11:112,961,420-113,278,436 (from NCBI)

This gene has 30 transcripts (splice variants), 278 orthologues and 36 paralogues. Biased expression in brain (RPKM 90.3), adrenal (RPKM 31.4) and 6 other tissues.

Summary

This gene encodes a cell adhesion protein which is a member of the immunoglobulin superfamily. The encoded protein is involved in cell-to-cell interactions as well as cell-matrix interactions during development and differentiation. The encoded protein plays a role in the development of the nervous system by regulating neurogenesis, neurite outgrowth, and cell migration. This protein is also involved in the expansion of T lymphocytes, B lymphocytes and natural killer (NK) cells which play an important role in immune surveillance. This protein plays a role in signal transduction by interacting with Fibroblast Growth Factor receptors, N-Cadherin and Other components of the extracellular matrix and by triggering signalling cascades involving FYN-focal adhesion kinase (FAK), mitogen-activated protein kinase (MAPK), and phosphatidylinositol 3-kinase (PI3K). One prominent isoform of this gene, cell surface molecule CD56, plays a role in several myeloproliferative disorders such as acute myeloid leukemia and differential expression of this gene is associated with differential disease progression. For example, increased expression of CD56 is correlated with lower survival in acute myeloid leukemia patients whereas increased severity of COVID-19 is correlated with decreased abundance of CD56-expressing NK cells in peripheral blood. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms. [provided by RefSeq, Aug 2020]

NCAM1 Products (31)

mRNA	Protein	Name
NM_000615.7	NP_000606.3	neural cell adhesion molecule 1 isoform 1 precursor
NM_001076682.4	NP_001070150.1	neural cell adhesion molecule 1 isoform 3 precursor
NM_001242607.2	NP_001229536.1	neural cell adhesion molecule 1 isoform 5 precursor
NM_001242608.2	NP_001229537.1	neural cell adhesion molecule 1 isoform 4 precursor
NM_001386289.1	NP_001373218.1	neural cell adhesion molecule 1 isoform 6 precursor
NM_001386290.1	NP_001373219.1	neural cell adhesion molecule 1 isoform 7 precursor
NM_001386291.1	NP_001373220.1	neural cell adhesion molecule 1 isoform 8 precursor
NM_001386292.1	NP_001373221.1	neural cell adhesion molecule 1 isoform 9 precursor
NM_001400603.1	NP_001387532.1	neural cell adhesion molecule 1 isoform 10 precursor
NM_001400604.1	NP_001387533.1	neural cell adhesion molecule 1 isoform 11 precursor
NM_001400605.1	NP_001387534.1	neural cell adhesion molecule 1 isoform 12 precursor
NM_001400606.1	NP_001387535.1	neural cell adhesion molecule 1 isoform 13 precursor
NM_001400607.1	NP_001387536.1	neural cell adhesion molecule 1 isoform 14 precursor
NM_001400608.1	NP_001387537.1	neural cell adhesion molecule 1 isoform 15 precursor
NM_001400609.1	NP_001387538.1	neural cell adhesion molecule 1 isoform 16 precursor
NM_001400610.1	NP_001387539.1	neural cell adhesion molecule 1 isoform 17 precursor
NM_001400611.1	NP_001387540.1	neural cell adhesion molecule 1 isoform 18
NM_001400612.1	NP_001387541.1	neural cell adhesion molecule 1 isoform 19 precursor
NM_001400613.1	NP_001387542.1	neural cell adhesion molecule 1 isoform 20
NM_001400614.1	NP_001387543.1	neural cell adhesion molecule 1 isoform 21
NM_001400615.1	NP_001387544.1	neural cell adhesion molecule 1 isoform 22 precursor
NM_001400616.1	NP_001387545.1	neural cell adhesion molecule 1 isoform 23 precursor
NM_001400617.1	NP_001387546.1	neural cell adhesion molecule 1 isoform 24 precursor
NM_001400618.1	NP_001387547.1	neural cell adhesion molecule 1 isoform 25 precursor
NM_001400619.1	NP_001387548.1	neural cell adhesion molecule 1 isoform 26
NM_001400620.1	NP_001387549.1	neural cell adhesion molecule 1 isoform 27 precursor
NM_001400621.1	NP_001387550.1	neural cell adhesion molecule 1 isoform 28 precursor
NM_001400622.1	NP_001387551.1	neural cell adhesion molecule 1 isoform 29 precursor
NM_001400623.1	NP_001387552.1	neural cell adhesion molecule 1 isoform 30 precursor
NM_001400624.1	NP_001387553.1	neural cell adhesion molecule 1 isoform 31 precursor
NM_181351.5	NP_851996.2	neural cell adhesion molecule 1 isoform 2 precursor

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32814053	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cell surface	IDA IDA: Inferred from direct assay	10766765	GOA
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	17213291	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NCAM1 Protein Structure

I-set

fn3

0
200
400
600
800
848 a.a.

Protein Preferred Names	Protein Names
neural cell adhesion molecule 1	antigen recognized by monoclonal antibody 5.1H11

Recombinant NCAM1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70687	NCAM-1/CD56 Protein, Human (HEK293, His)	P13591-3 (L20-P603)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P75932	NCAM-1/CD56 Protein, Human (HEK293, His-Avi)	P13591-3 (L20-P603)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P75933	NCAM-1/CD56 Protein, Human (HEK293, His, solution)	P13591-3 (L20-P603)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P78647	FITC-Labeled NCAM-1/CD56 Protein, Human (HEK293, Fc)	P13591-2 (L20-G718)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P78648	FITC-Labeled NCAM-1/CD56 Protein, Human (HEK293, His)	P13591-2 (L20-G718)	≥ 90%, as determined by reducing SDS-PAGE.

NCAM1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83477	CD56 Antibody (YA3222)	WB, IHC-P, ICC/IF, IP, FC	Human
HY-P84083	CD56 Antibody (YA3780)	WB, IHC-P, FC, ELISA	Human, Mouse, Monkey
HY-P84083A	CD56 Antibody (YA3780)(PBS only)	WB, IHC-P, FC, ELISA	Human, Mouse, Monkey
HY-P84998	CD56 Antibody (YA4690)	ELISA, FC	Human
HY-P85951	CD56 Antibody (YA5643)	IHC-P, WB, ICC/IF, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Rabies	Lyssa Hydrophobia St Hubert Disease
Bile Duct Cancer	Bile Duct Carcinoma Extrahepatic Bile Duct Carcinoma Carcinoma Of Extrahepatic Bile Duct Extrahepatic Bile Duct Cancer Bile Duct Neoplasms Bile Duct Tumor Ca Extrahepatic Bile Ducts Malignant Neoplasm Of The Extrahepatic Bile Duct Bile Duct Extrahepatic Carcinoma Malignant Tumor Of Extrahepatic Bile Duct
Plasma Cell Leukemia	Plasma Cell Leukaemia Leukemia, Plasma Cell Plasmacytic Leukaemia Plasmacytic Leukemia Pcl Plasma Cell Leukaemia, Nos Leukemic Plasma Cell Plasma Cell Leukaemia Without Mention Of Remission
Merkel Cell Carcinoma	Trabecular Adenocarcinoma Cutaneous Neuroendocrine Carcinoma Trabecular Carcinoma Carcinoma, Merkel Cell Merkel Cell Cancer Merkle Tumors Mcc Carcinoma Merkel Cell
Neuroendocrine Carcinoma	Neuroendocrine Cancer Carcinoma Neuroendocrine Carcinoma, Neuroendocrine
Aggressive Nk-Cell Leukemia	Aggressive Nk-Cell Leukaemia Large Granular Lymphocyte Leukemia, Nk-Cell Type Natural Killer Cell Leukaemia Natural Killer Cell Leukemia Aggressive Nk Cell Leukemia Ankl Aggressive Natural Killer Cell Leukemia Ankcl Aggressive Nk-Cell Lymphoma Nk-Cell Lgl Leukemia Nk-Cell Large Granular Lymphocyte Leukemia Abnormality Of The Ankles Aggressive Natural Killer-Cell Leukemia Leukemia, Large Granular Lymphocytic Leukemia, Natural Killer Cell Large Granular Lymphocytic
T-Cell Large Granular Lymphocyte Leukemia	Large Granular Lymphocytic Leukemia Proliferation Of Large Granular Lymphocytes T-Lgl T-Cell Lgl Leukemia Large Granular Lymphocytic Leukaemia T-Cell Large Granular Lymphocyte Leukaemia Large Cell Granular Lymphogenous Leukemia T-Lgl Leukemia Leukemia Lymphocytic Large Granular Leukemia, Large Granular Lymphocytic
Myxopapillary Ependymoma	Ependymoma Myxopapillary
Ganglioneuroma
Panniculitis	Nodular Panniculitis
Nasal Cavity Lymphoma	Lymphoma Of Nasal Cavity Lymphoma Of The Nasal Cavity
Orbit Lymphoma	Orbital Lymphoma Lymphoma Of The Orbit
Nasal Type Extranodal Nk/T-Cell Lymphoma	Extranodal Nasal Nk/T Cell Lymphoma Angiocentric T-Cell Lymphoma Lethal Midline Granuloma Nk/T-Cell Lymphoma Nktcl Nasal T/Natural Killer-Cell Lymphoma Granuloma, Lethal Midline Nasal And Nasal-Type Nk/T-Cell Lymphoma
Large Cell Neuroendocrine Carcinoma
Primary Cutaneous Gamma-Delta T-Cell Lymphoma	Cutaneous Gamma/Delta T-Cell Lymphoma Primary Cutaneous Gamma-Delta T Cell Lymphomas Doid:0081050
Myeloid Sarcoma	Granulocytic Sarcoma Chloroma Extramedullary Myeloid Tumor Sarcoma, Granulocytic Sarcoma Granulocytic Sarcoma, Myeloid Myelosarcoma Myeloid Sarcoma Disease Myeloid Sarcoma Nos Myeloid Sarcoma Without Mention Of Remission
Nasal Cavity Cancer	Nasal Cavity Carcinoma Malignant Neoplasm Of Nasal Cavities Malignant Tumor Of The Nasal Cavity Cancer Of Nasal Cavity Carcinoma Of Nasal Cavity Malignant Neoplasm Of Nasal Cavity Neoplasm Of Nasal Cavity
Plasmacytoma	Solitary Plasmacytoma Solitary Myeloma Myeloma - Solitary Myeloma, Solitary Plasmacytoma - Category Solitary Osseous Plasmacytoma Solitary Plasmacytoma Without Mention Of Remission Localised Malignant Plasma Cell Tumour Nos Plasmacytoma Nos
Lung Large Cell Carcinoma	Large Cell Carcinoma Of Lung Large Cell Lung Carcinoma Large Cell Lung Cancer
Spinal Muscular Atrophy, Type Ii	SMA2 Sma Ii Muscular Atrophy, Spinal, Intermediate Type Muscular Atrophy, Spinal, Infantile Chronic Form Intermediate Spinal Muscular Atrophy Spinal Muscular Atrophy Type Ii Spinal Muscular Atrophy-2 Spinal Muscular Atrophy 2 Spinal Muscular Atrophy Type 2 Dubowitz Disease Proximal Spinal Muscular Atrophy Type 2 Sma Type 2 Sma Type Ii Sma-Ii Spinal Muscular Atrophy Infantile Chronic Form Spinal Muscular Atrophy Intermediate Type Spinal Muscular Atrophies Of Childhood Atrophy, Muscular, Spinal, Type Ii Muscular Atrophy, Spinal, Type Ii
Adenoid Cystic Carcinoma	Adenocystic Carcinoma Cribriform Carcinoma Cylindroma Carcinoma Adenoid Cystic Carcinoma, Adenoid Cystic Adenoid Cystic Carcinoma Of Salivary Gland Eccrine Dermal Cylindroma Carcinoma, Cribriform
Chordoma	CHDM Notochordoma Notochordal Sarcoma Chordoma, Susceptibility To Chordocarcinoma Chordoepithelioma
Monoclonal Paraproteinemia	Monoclonal Paraproteinaemia
Ewing Sarcoma	Neuroepithelioma Ewing'S Tumor Primitive Neuroectodermal Tumor Ewings Sarcoma Ewing'S Sarcoma Peripheral Neuroepithelioma ES Ewings Sarcoma-Primitive Neuroectodermal Tumor Localized Peripheral Primitive Neuroectodermal Tumor Peripheral Primitive Neuroectodermal Tumor Ewing Tumor Sarcoma, Ewing'S Ewing Family Of Tumors Extraosseous Ewing Tumor Askin Tumor Ewing'S Family Localized Tumor Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor Localized Ewing Sarcoma Localized Ewing'S Sarcoma Localized Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor Localized Ewing'S Tumor Pnet Of Thoracopulmonary Region Tumor Of The Ewing Family Skeletal Ewing Sarcoma Osseous Ewing Sarcoma Ppnet Peripheral Pnet Extraskeletal Ewing Sarcoma Eoe Extraosseous Ewing Sarcoma Extraskeletal Ewing Tumor Esft Ewing Sarcoma Family Of Tumors Pne Pnet Pnet Of The Chest Wall Sarcoma, Ewing Neuroectodermal Tumors, Primitive, Peripheral Neuroectodermal Tumor, Primitive Disorder Of Eye Askin'S Tumor Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor Neuroepithelioma, Peripheral
Lethal Midline Granuloma	Granuloma, Lethal Midline Malignant Granuloma Of Face Midfacial Necrotising Lesion Midline Lethal Granuloma
Paraganglioma	Chemodectoma Glomus Body Tumor Paragangliomas Carotid Body Paraganglioma Extra-Adrenal Paraganglioma
Chronic Nk-Cell Lymphocytosis	Nk-Cell Large Granular Lymphocyte Lymphocytosis Chronic Lymphoproliferative Disorder Of Nk-Cells
Transitional Meningioma	Transitional Meningioma
Myeloid Leukemia	Myeloid Leukaemia Leukaemia Myelogenous Leukemia Myelogenous Myeloid Granulocytic Leukaemia Myeloid Granulocytic Leukemia Non-Lymphocytic Leukemia Leukemia, Myeloid Granulocytic Leukaemia Myelogenous Leukaemia Myeloid Leukaemia, Unspecified, Without Mention Of Remission
Small Cell Cancer Of The Lung	Small Cell Lung Cancer Small Cell Lung Carcinoma Sclc Small-Cell Cancer Of Lung Lung Small Cell Carcinoma Sclc1 Sccl Cancer, Lung, Small Cell Small Cell Carcinoma Of Lung Carcinoma, Small Cell
Neuroendocrine Tumor	Neuroendocrine Neoplasm Neuroendocrine Tumors Carcinoma, Neuroendocrine
Cutaneous Leishmaniasis	Diffuse Cutaneous Leishmaniasis Asian Desert Cutaneous Leishmaniasis Leishmaniasis, Cutaneous Leproid Leishmaniasis Leishmaniasis Diffuse Cutaneous Leishmaniasis Cutaneous Ethiopian Cutaneous Leishmaniasis Old World Cutaneous Leishmaniasis
Prion Disease	Spongiform Encephalopathy Transmissible Spongiform Encephalopathies Prion Diseases Prion Disease Pathway Transmissible Spongiform Encephalopathy Prion Induced Disorder Prion Protein Disease Inherited Human Transmissible Spongiform Encephalopathies Prion Protein Diseases Prion-Associated Disorders Prion-Induced Disorders Transmissible Dementias Tses Human Prion Disease Tse Encephalopathy, Transmissible Spongiform Prion Disease, Susceptibility To Spongiform Encephalopathies Human Transmissible Spongiform Encephalopathies, Inherited
Hepatosplenic T-Cell Lymphoma	Doid:0081049
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Myositis	Idiopathic Inflammatory Myopathy Idiopathic Inflammatory Myositis Iim Imm Idiopathic Inflammatory Myopathies Myopathy, Familial Idiopathic Inflammatory Inflammatory Disorder Of Muscle Idiopathic Inflammatory Myopathy, Familial Inflammatory Myopathy, Idiopathic Myopathies Idiopathic Inflammatory Familial Idiopathic Inflammatory Myopathy
Orbital Cellulitis	Cellulitis Of Orbit
Acute Orbital Inflammation	Acute Inflammation Of Orbit
Gastric Small Cell Carcinoma	Small Cell Carcinoma Of Stomach
Benign Teratoma	Dermoid Cyst Cystic Dermoid Choristoma Dermoid Choristoma Mature Cystic Teratoma Dermoid Tumour Teratoma, Benign Dermoid Cyst Of Ovary
Esophageal Neuroendocrine Tumor	Esophageal Neuroendocrine Tumour Neuroendocrine Tumor Of Esophagus Neuroendocrine Tumour Of Oesophagus
Extramedullary Plasmacytoma	Extraosseous Plasmacytoma Plasmacytoma, Extramedullary
Pulmonary Large Cell Neuroendocrine Carcinoma	Large Cell Lung Neuroendocrine Carcinoma
Acute Leukemia	Stem Cell Leukaemia Stem Cell Leukemia Acute Leukemias Acute Undifferentiated Leukemia Undifferentiated Leukemia Acute Leukaemia Of Unspecified Cell Type Without Mention Of Remission Blast Cell Leukaemia Blast Leukaemia Blastic Leukaemia Undifferentiated Leukaemia
Endometrial Small Cell Carcinoma
Drug Dependence
Solitary Osseous Plasmacytoma	Isolated Osseous Plasmacytoma Solitary Plasmacytoma Of Bone
Urinary Bladder Small Cell Neuroendocrine Carcinoma	Small Cell Neuroendocrine Carcinoma Of The Urinary Bladder Small Cell/Neuroendocrine Carcinoma Of Urinary Bladder
Ureter Small Cell Carcinoma	Ureteral Small Cell Carcinoma
Pulmonary Neuroendocrine Tumor	Neuroendocrine Neoplasm Of Lung
Laryngeal Small Cell Carcinoma	Small Cell Carcinoma Of Larynx
Centronuclear Myopathy	Myopathy, Centronuclear Myotubular Myopathy Cnm Myopathy, Myotubular Congenital Structural Myopathy
Hepatic Encephalopathy	Encephalopathy, Hepatic Portal-Systemic Encephalopathy Hepatoencephalopathy He - [Hepatic Encephalopathy] Hepatic Encephalopathy Nos Hepatic Encephalopathy, Stage Unspecified Hepatic Coma Hepatocerebral Encephalopathy Hepatocerebral Intoxication
Malignant Olfactory Nerve Neoplasm	Malignant Olfactory Nerve Tumor Malignant Tumor Of Olfactory Nerve Primary Malignant Neoplasm Of Olfactory Nerve
Peripheral T-Cell Lymphoma	Lymphoma T-Cell Peripheral
Mycosis Fungoides	Mycosis Fungoides Lymphoma Alibert-Bazin Syndrome Granuloma Fungoides Classic Mycosis Fungoides Mycosis Fungoides, Alibert-Bazin Type
Small Cell Carcinoma	Small Cell Carcinoma, Intermediate Cell Intermediate Cell Small Cell Carcinoma Small Cell Carcinoma - Intermediate Cell Small Cell Carcinoma Of Lung Carcinoma, Small Cell
Lung Benign Neoplasm	Lung Neoplasms Tumor Of The Lung Lung Tumor
Ovarian Large-Cell Neuroendocrine Carcinoma	Non-Small-Cell Type Neuroendocrine Carcinoma Of Ovary Ovarian Large Cell Neuroendocrine Carcinoma
Pheochromocytoma	Pheochromocytoma, Susceptibility To Phaeochromocytoma Adrenal Gland Chromaffin Paraganglioma Adrenal Gland Chromaffinoma Adrenal Gland Paraganglioma Adrenal Gland Pheochromocytoma Chromaffin Paraganglioma Of The Adrenal Gland Intraadrenal Paraganglioma PCC Chromaffin Cell Tumor Medullary Chromaffinoma Medullary Paraganglioma Pheochromoblastoma Pheochromocytomas Chromaffin Cell Neoplasm Pheochromocytoma, Malignant
Ovarian Mucinous Adenofibroma
Ovarian Mucinous Cystadenofibroma
Cutaneous Ganglioneuroma	Ganglioneuroma Of Skin
Acute Promyelocytic Leukemia	Leukemia, Acute Promyelocytic Acute Myeloblastic Leukemia Type 3 Aml M3 APL Leukemia, Acute Promyelocytic, Somatic Aml With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Apml Acute Myeloblastic Leukemia 3 Acute Myeloid Leukemia With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Acute Myeloblastic Leukaemia Type 3 Acute Myeloid Leukaemia M3 Acute Myeloid Leukemia M3 Acute Promyelocytic Leukaemia M3 Anll Myeloid Leukemia, Acute, M3 Leukemia Promyelocytic Acute Leukemia, Promyelocytic, Acute Leukemia, Acute, Promyelocytic
Cardiac Arrest	Cardiopulmonary Arrest Circulatory Arrest Heart Arrest
Medulloblastoma	MDB Cpnet Localized Primitive Neuroectodermal Tumor Classic Medulloblastoma Medulloblastoma Predisposition Syndrome Medulloblastoma, Somatic Brain Medulloblastoma Cns Pnet Infratentorial Primitive Neuroectodermal Tumor Neuroectodermal Tumors, Primitive Medulloblastomas Desmoplastic Medulloblastoma Medulloblastoma, With Extensive Nodularity Medulloblastoma Of Unspecified Site Medullomyoblastoma Of Unspecified Site
Myeloma, Multiple	Multiple Myeloma Plasma Cell Myeloma Kahler Disease Myelomatosis Medullary Plasmacytoma Multiple Myeloma, Resistance To Myeloma Plasma Cell Dyscrasia Kahler'S Disease Multiple Myeloma, Susceptibility To Myeloma - Multiple Kahler-Bozzolo Disease Plasma Cell Myelomas MM Plasma Cell Neoplasm Primary Systemic Amyloidosis Primary Amyloidosis Immunoglobulin Deposition Disease Plasmacytic Myeloma Multiple Myelomata Multiple Myeloma Nos Multiple Myeloma Without Mention Of Remission Monostotic Plasma Cell Myeloma Mm - [Multiple Myeloma]
Tubular Adenocarcinoma	Tubular Carcinoma Adenocarcinoma Tubular Adenocarcinoma, Tubular
Middle Ear Adenoma	Adenoma Of Middle Ear Adenoma Of The Middle Ear
Auditory System Benign Neoplasm
Ovarian Serous Cystadenofibroma
Rete Testis Adenoma
Intrahepatic Bile Duct Adenoma	Adenoma Of Intrahepatic Bile Duct Adenoma Of The Intrahepatic Bile Duct
Cranial Nerve Malignant Neoplasm	Cranial Nerve Neoplasms Malignant Neoplasm Of Cranial Nerve Malignant Tumor Of Cranial Nerve Malignant Tumor Of The Cranial Nerve
Basaloid Squamous Cell Carcinoma	Basaloid Carcinoma
Anal Neuroendocrine Tumor	Anal Neuroendocrine Tumour Neuroendocrine Tumor Of Anus Neuroendocrine Tumour Of Anus Anal Canal Neuroendocrine Tumor
Cholangiolocellular Carcinoma
Mature T-Cell And Nk-Cell Lymphoma	Mature T-Cell And Natural Killer Cell Lymphoma Nk-T Cell Lymphoma
Ovarian Serous Adenofibroma
Embryonal Rhabdomyosarcoma	Rhabdomyosarcoma, Embryonal Rhabdomyosarcoma Embryonal Botryoid Rhabdomyosarcoma Erms Spindle Cell Rhabdomyosarcomas
Periampullary Adenocarcinoma
Bile Duct Adenoma	Cholangioadenoma Adenoma Bile Duct Adenoma, Bile Duct
Mediastinal Cancer	Mediastinal Neoplasms Mediastinal Tumor Mediastinum Cancer Neoplasm Of Mediastinum Tumour Of Mediastinum Malignant Tumor Of Mediastinum
Bladder Small Cell Carcinoma	Small Cell Bladder Cancer Small Cell Carcinoma Of The Bladder Poorly Differentiated Neuroendocrine Carcinoma Of The Bladder Sccb Small Cell Bladder Carcinoma Small Cell Carcinoma Of The Urinary Bladder
Neural Tube Defects	Spina Bifida Neural Tube Defect NTD Neural Tube Defects, Susceptibility To Spinal Dysraphism Spina Bifida, Susceptibility To Rachischisis Cleft Spine Open Spine Hydrocele Spinalis Neural Tube Defect Nos Sb - [Spina Bifida] Spinal Hernia Nos Spinal Fissure Nos
Nk Cell Deficiency
Cervix Small Cell Carcinoma	Small Cell Carcinoma Of The Cervix Small Cell Carcinoma Of The Cervix Uteri
Monoclonal Gammopathy Of Uncertain Significance	Monoclonal Gammopathy Of Undetermined Significance Mgus Mgus - [Monoclonal Gammopathy Of Undetermined Significance] Monoclonal Gammopathy Nos Iga Gammopathy Monoclonal Gammoglobulinopathy
Non-Secretory Myeloma
Olfactory Neuroblastoma	Esthesioneuroblastoma Asthesioneuroblastoma Esthesioneuroepithelioma Olfactory Esthesioneuroblastoma Paranasal Sinus Olfactory Neuroblastoma Esthesioneuroblastoma, Olfactory Esthesioneuroblastoma Of Nasal Cavity
Biliary Tract Benign Neoplasm	Extrahepatic Bile Duct Neoplasm Neoplasm Of Extrahepatic Bile Ducts Tumor Of The Extrahepatic Bile Duct
Renal Adenoma	Renal Cell Adenoma
Orbital Cancer	Malignant Neoplasm Of Orbit Orbital Tumor Orbital Neoplasms Neoplasm Of Orbit Proper Orbit Cancer Primary Malignant Neoplasm Of Orbit Intraorbital Cancer
Cholangiocarcinoma	Cholangiocarcinoma, Susceptibility To Extrahepatic Cholangiocarcinoma Intrahepatic Cholangiocarcinoma Chlc Chlc, Susceptibility To Cc Cholangiocarcinoma Of Biliary Tract Cholangiocellular Carcinoma Distal Cholangiocarcinoma Perihilar Cholangiocarcinoma Bile Duct Cancer Cca Adult Primary Cholangiocellular Carcinoma Bile Duct Carcinoma
Metanephric Adenoma
Extraosseous Ewing Sarcoma	Extraosseous Ewing'S Sarcoma Extraosseous Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor Extraskeletal Ewing Sarcom Sarcoma Extraosseous Ewings Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor
Infected Hydrocele	Pyocele
Gastrointestinal Neuroendocrine Benign Tumor
Hirschsprung Disease 1	Hirschsprung Disease Aganglionic Megacolon Hscr Hirschsprung'S Disease Congenital Megacolon Congenital Intestinal Aganglionosis Colonic Aganglionosis Hirschsprung Disease, Susceptibility To, 1 Hirschsprung Disease, Protection Against HSCR1 Mgc Pelvirectal Achalasia Total Intestinal Aganglionosis Megacolon, Aganglionic Macrocolon Hscr 1 Hirschsprung Disease Type 1 Hirschsprung Disease, Type 1 Congenital Dilatation Of Colon Aganglionosis Congenital Aganglionic Megacolon Aganglionosis Of Colon Bowel Aganglionosis Colon Aganglionosis Hirschsprung Megacolon
Ovarian Germ Cell Teratoma	Germ Cell Teratoma Of Ovary Ovarian Teratoma
Rectum Lymphoma	Lymphoma Of Rectum
Scleredema Adultorum	Scleredema Buschke'S Scleredema Scleredema Adultorum Of Buschke Scleredema Diabeticorum Scleredema Diabeticorum Of Buschke Buschke Scleredema
Orbital Disease	Orbit Orbital Diseases
Sinonasal Undifferentiated Carcinoma	Highly Aggressive Undifferentiated Carcinoma Of The Nasal Cavity And Paranasal Sinuses Snuc
Cystic Teratoma	Dermoid Cyst Benign Teratoma
Sensory Organ Benign Neoplasm
Gastrointestinal Neuroendocrine Tumor	Gastrointestinal Neuroendocrine Tumour Malignant Gastrointestinal Neuroendocrine Tumor Malignant Gastrointestinal Neuroendocrine Tumour Digestive System Neuroendocrine Neoplasm Digestive System Neuroendocrine Tumor
Emery-Dreifuss Muscular Dystrophy	Edmd Emery-Dreifuss Syndrome Muscular Dystrophy, Emery-Dreifuss Humeroperoneal Neuromuscular Disease Muscular Dystrophy, Tardive, Dreifuss-Emery Type, With Contractures Scapuloperoneal Syndrome, X-Linked Benign Scapuloperoneal Muscular Dystrophy With Early Contractures Muscular Dystrophy, Emery-Dreifuss Type Muscular Dystrophy Emery-Dreifuss Dystrophy, Muscular, Emery-Dreifuss Emd - [Emery-Dreifuss Muscular Dystrophy]
Gastrointestinal Lymphoma
Lymphoepithelioma-Like Carcinoma	Lymphoepithelial Carcinoma Nasopharyngeal Type Undifferentiated Carcinoma
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Laryngeal Neuroendocrine Tumor	Laryngeal Neuroendocrine Tumour Neuroendocrine Tumor Of Larynx Neuroendocrine Tumour Of Larynx Neuroendocrine Neoplasm Of Larynx
Prostatic Urethral Cancer
Gastric Neuroendocrine Neoplasm	Gastric Neuroendocrine Tumor Neuroendocrine Tumor Of The Stomach Neuroendocrine Tumor Of Stomach Gnet Gastric Net Net Of Stomach
Bilateral Hypoactive Labyrinth	Hypoactive Bilateral Labyrinthine Dysfunction Hypoactive Labyrinth, Bilateral
Gallbladder Small Cell Carcinoma	Oat Cell Carcinoma Of The Gallbladder Gallbladder Small Cell Neuroendocrine Carcinoma
Sternum Cancer	Malignant Sternal Neoplasm Neoplasm Of Sternum
Sternum Lymphoma	Lymphoma Of Sternum Lymphoma Of The Sternum
Smoldering Myeloma
Alcohol Dependence	Alcoholism Alcohol Dependence, Susceptibility To Alcohol Dependence, Protection Against Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against Alcoholism, Susceptibility To Alcoholic Intoxication, Chronic Pharyngeal Neoplasms Chronic Alcoholism Dipsomania Alcohol Addiction Ethanol Dependence Chronic Ethanolism Chronic Alcoholic Disease Nos Alcoholic Disease Nos Alcoholic
Ovarian Sex-Cord Stromal Tumor	Ovarian Sex Cord Tumor With Annular Tubules Ovarian Sex Cord-Stromal Tumor Stromal Tumor Of Ovary
Paranasal Sinus Cancer	Paranasal Sinus Adenoid Cystic Carcinoma Paranasal Sinus Mucoepidermoid Carcinoma Paranasal Sinus Squamous Cell Carcinoma Paranasal Sinus Neoplasms Adenoid Cystic Carcinoma Of Accessory Sinus Adenoid Cystic Carcinoma Of Paranasal Sinus Epidermoid Carcinoma Of The Paranasal Sinus Mucoepidermoid Carcinoma Of Accessory Sinus Paranasal Sinus Adenocarcinoma Squamous Cell Carcinoma Of Paranasal Sinus Paranasal Sinus Neoplasm Adenocarcinoma Of Accessory Sinus
Neurofibroma Of The Esophagus
Adult Type Testicular Granulosa Cell Tumor
Solid Adenocarcinoma With Mucin Production
Hydrocephalus	Hydrocephalus, Nonsyndromic, Autosomal Recessive Hydrocephalus, X-Linked Hydrocephalus Adverse Event Hydrocephaly Nos
Human Immunodeficiency Virus Infectious Disease	Hiv Infections
Cerebellopontine Angle Primitive Neuroectodermal Tumor	Cerebellopontine Angle Pnet
Fallopian Tube Carcinosarcoma	Fallopian Tube Malignant Mixed Mesodermal Tumor Fallopian Tube Malignant Mixed Mullerian Tumor
Prostate Stromal Sarcoma	Stromal Sarcoma Of The Prostate
Breast Granular Cell Tumor
Mature B-Cell Neoplasm	Mature B-Cell Lymphocytic Neoplasm Neoplasm Of Mature B-Cells Mature B-Cell Non-Hodgkin Neoplasm With Leukaemic Behaviour
Prostate Neuroendocrine Neoplasm	Neuroendocrine Tumor Of The Prostate
Blood Protein Disease	Blood Protein Disorders Blood Protein Disorder
Neurohypophysis Granular Cell Tumor	Granular Cell Tumor Of The Neurohypophysis
Neuroblastoma	Nb Neuroblastoma, Susceptibility To Neuroblastomas Central Neuroblastoma
Leukocyte Disease	Leukocyte Disorders
Gastric Hemangioma	Hemangioma Of Stomach
Intestinal Perforation	Perforation Of Intestine
Vulvar Leiomyoma
Papillary Thymic Adenocarcinoma	Papillary Carcinoma Of The Thymus
Isthmus Cancer
Islet Cell Tumor	Pancreatic Neuroendocrine Tumor Neuroendocrine Tumor Of Pancreas Pnet Pancreatic Net Pancreatic Endocrine Tumor Well-Differentiated Nen Of Pancreas Well-Differentiated Neuroendocrine Neoplasm Of Pancreas Well-Differentiated Pancreatic Nen Well-Differentiated Pancreatic Neuroendocrine Neoplasm Endocrine Pancreas Cancer Islet Cell Neoplasm Islet Cell Tumour Malignant Pancreatic Endocrine Tumor Malignant Pancreatic Endocrine Tumour Malignant Tumor Of Endocrine Pancreas Malignant Tumour Of Endocrine Pancreas Pancreatic Endocrine Neoplasm Pancreatic Neuroendocrine Neoplasm Adenoma, Islet Cell Well Differentiated Pancreatic Endocrine Tumor Malignant Neoplasm Of Endocrine Pancreas Pancreatic Endocrine Carcinoma
Hemophagocytic Lymphohistiocytosis	Lymphohistiocytosis, Hemophagocytic Haemophagocytic Syndrome Lymphohistiocytosis Hemophagocytic Hemophagocytic Syndrome Familial Hemophagocytic Lymphocytosis Histiocytoses Of Mononuclear Phagocytes Haemophagocytic Lymphohistiocytosis Nos
Mechanical Ectropion
Bone Marrow Cancer	Malignant Neoplasm Of Bone Marrow Bone Marrow Neoplasm Bone Marrow Tumor Malignant Bone Marrow Tumor Myeloproliferative Disorders Bone Marrow Neoplasms Myeloproliferative Disease Chronic Myeloproliferative Disorder
Hypertryptophanemia	HYPTRP Hypertryptophanemia, Familial Familial Hypertryptophanemia
Meningioma, Familial	Meningioma Familial Meningioma Meningioma, Familial, Susceptibility To Meningeal Neoplasm Meningeal Neoplasms Meningiomas Meningioma, Nf2-Related, Somatic Meningioma, Sis-Related Meningothelial Cell Tumor Neoplasm Of The Meninges Primary Meningeal Tumor Familial Multiple Meningioma MNGMA Meningioma, Benign, No Icd-O Subtype Intracranial Meningioma Meningothelial Cell Neoplasm Supratentorial Meningioma Primary Neoplasm Of Spinal Meninges Benign Intracranial Meningioma Benign Meningioma Meningeal Tumours Meningeal Sarcoma Of Unspecified Site Meningothelial Sarcoma Of Unspecified Site
Mucinous Adenofibroma
Skeletal Muscle Cancer	Malignant Tumor Of Skeletal Muscle Skeletal Muscle Neoplasm
Muscle Cancer	Myosarcoma Malignant Neoplasm Of Muscle Malignant Tumor Of Muscle Malignant Tumor Of The Muscle Muscle Neoplasms Myomatous Neoplasm
Pfeiffer Syndrome	Infectious Mononucleosis Acs5 Craniofacial-Skeletal-Dermatologic Dysplasia Acs V Noack Syndrome Gammaherpesviral Mononucleosis Acrocephalosyndactyly Type 5 Pfeiffer Syndrome Type 3 Acrocephalosyndactyly, Type V Glandular Fever Pfeiffer Type Acrocephalosyndactyly Pfeiffer Syndrome Type 2 Acrocephalosyndactylia Type V Filatov'S Disease Monocytic Angina Mononucleosis Pfeiffer'S Disease Acsv Acrocephalosyndactyly, Type 5 Craniofacial-Skeletal-Dermatologic Syndrome Pfeiffer Syndrome Type 1 Classic Pfeiffer Syndrome PS Pfeiffer Syndrome Variant Dysplasia, Craniofacial-Skeletal-Dermatologic Pfeiffer Kissing Disease Infectious Adenitis Pfeiffer Disease
Breast Rhabdomyosarcoma	Rhabdomyosarcoma Of The Breast
Plasma Cell Neoplasm	Plasma Cell Dyscrasia Paraproteinemias Plasma Cell Tumour Plasmacytic Tumor Multiple Myeloma Plasmacytoma Plasma Cell Tumours Plasma Cells Dyscrasia
Pancytopenia
Nasal Cavity Olfactory Neuroblastoma	Olfactory Neuroblastoma Of The Nasal Cavity
Sezary'S Disease	Sezary Syndrome Sézary Syndrome Sezary'S Lymphoma Sezary Disease Sezary Erythroderma Sezary Lymphoma
Ovary Leiomyosarcoma	Leiomyosarcoma Of Ovary
Neuromuscular Disease	Neuromuscular Diseases Neuromuscular Disorders Neuromuscular Disorder
Appendix Lymphoma	Appendiceal Lymphoma
Blood Platelet Disease	Platelet Disorder Blood Platelet Disorders Thrombocytopathy Platelet Dysfunction Platelet Disorders Qualitative Platelet Deficiency
Rhabdomyosarcoma 2	Alveolar Rhabdomyosarcoma Rhabdomyosarcoma, Alveolar Rhabdomyosarcoma Alveolar RMS2 Rmsa Rhabdomyosarcoma 2, Alveolar Alveolar Childhood Rhabdomyosarcoma Arms Rhabdomyosarcoma, Type 2
Wilms Tumor 1	Nephroblastoma Wilms Tumor WT1 Wilms' Tumor Bilateral Wilms Tumor Wilms Tumor, Type 1 Wilms Tumor, Somatic Adult Nephroblastoma Wt1 Disorder Renal Embryonic Tumor Adult Kidney Wilms Tumor Childhood Kidney Wilms Tumor Nonanaplastic Kidney Wilms Tumor
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1
Celiac Disease 1	Celiac Disease Coeliac Disease Celiac Sprue Celiac Disease, Susceptibility To Gluten-Sensitive Enteropathy Nontropical Sprue Sprue CELIAC1 Celiac Disease, Susceptibility To, 1 Celiac Sprue 1 Celiac Sprue, Susceptibility To, 1 Gluten-Sensitive Enteropathy 1 Gluten-Sensitive Enteropathy, Susceptibility To, 1 Idiopathic Steatorrhea Cœliac Disease Gluten Intolerance Gluten-Induced Enteropathy Gluten Enteropathy Celiac Disease, Susceptibility To, Type 1 Childhood Celiac Disease Coeliac Rickets Gee Disease Gee-Herter Disease Heubner-Herter Disease Idiopathic Steatorrhoea Thaysen'S Disease Herter Gee Syndrome
Myopathy	Muscular Diseases Myopathies
Gastrointestinal Stromal Tumor	GIST Gastrointestinal Stromal Tumors Gastrointestinal Stromal Sarcoma Gastrointestinal Stromal Tumor, Familial Gant Gastrointestinal Stromal Tumour Stromal Tumor Of Gastrointestinal Tract Stromal Tumour Of Gastrointestinal Tract Gastrointestinal Stromal Neoplasm Paraganglioma And Gastric Stromal Sarcoma Plexosarcoma
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Peripheral Nervous System Disease	Peripheral Neuropathy Peripheral Nerve Disease Peripheral Nerve Disorders Neuropathy, Peripheral Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation
Lymphoma, Non-Hodgkin, Familial	Non-Hodgkin Lymphoma Lymphoma, Non-Hodgkin NHL Lymphoma, Non-Hodgkin, Somatic Lymphoma, Follicular, Somatic Familial Non-Hodgkin Lymphoma Lymphoma Non-Hodgkins Follicular Lymphoma, Somatic Lymphosarcoma Non-Hodgkins Lymphoma
Myelodysplastic Syndrome	Myelodysplastic Syndromes Myelodysplasia MDS Myelodysplastic Syndrome Included Myelodysplastic Syndrome, Susceptibility To, Included Myelodysplastic Syndrome, Somatic Myelodysplastic Syndrome, Susceptibility To
Skin Disease	Skin Diseases Genodermatosis Abnormality Of The Skin Skin Diseases, Genetic Skin And Subcutaneous Tissue Disease Dermatologic Disorders
Leukemia, Chronic Lymphocytic	Chronic Lymphocytic Leukemia B-Cell Chronic Lymphocytic Leukemia CLL B-Cell Chronic Lymphoid Leukemia Chronic Lymphatic Leukemia Chronic Lymphocytic Leukaemia Lymphoplasmacytic Leukemia Small Lymphocytic Lymphoma Leukemia, Chronic Lymphatic B-Cell Chronic Lymphocytic Leukaemia Chronic Lymphatic Leukaemia Lymphoplasmacytic Leukaemia B Cell Chronic Lymphocytic Leukemia Chronic B-Cell Lymphocytic Leukemia Leukemia, Lymphocytic, Chronic B-Cll Chronic Lymphoid Leukemia Leukemia Lymphocytic Chronic Lymphoma Small Lymphocytic Leukemia, Lymphocytic, Chronic, B-Cell
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive MoleculesInhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99372	Lorvotuzumab		99.77%	Phase 2

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09063	NCAM1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17707	Ncam1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24172	Ncam1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	NCAM1	RGD	RGD:67378
Bos taurus	NCAM1	VGNC	VGNC:31898
Canis familiaris	NCAM1	VGNC	VGNC:43636
Macaca mulatta	NCAM1	VGNC	VGNC:75136
Mus musculus	NCAM1	MGD	MGI:97281
Felis catus	NCAM1	VGNC	VGNC:68421
Others	NCAM1	NCBI