Nfatc2 - nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2 Gene

Also Known as NFAT1; Nfatp; NF-ATp; NF-ATc2; NFAT1-D

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18019

Summary

Enables DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of gene expression. Acts upstream of or within several processes, including calcineurin-NFAT signaling cascade; myotube cell development; and positive regulation of myoblast fusion. Located in chromatin; cytosol; and nucleus. Part of ribonucleoprotein complex and transcription regulator complex. Is expressed in several structures, including brain; genitourinary system; jaw; spinal cord; and thymus primordium. Orthologous to human NFATC2 (nuclear factor of activated T cells 2). [provided by Alliance of Genome Resources, Apr 2022]

Nfatc2 Products (16)

mRNA Protein Name
NM_001037177.2 NP_001032254.1 nuclear factor of activated T-cells, cytoplasmic 2 isoform b
NM_001037178.2 NP_001032255.1 nuclear factor of activated T-cells, cytoplasmic 2 isoform c
NM_001136073.2 NP_001129545.1 nuclear factor of activated T-cells, cytoplasmic 2 isoform d
NM_001291168.1 NP_001278097.1 nuclear factor of activated T-cells, cytoplasmic 2 isoform e
NM_001291169.1 NP_001278098.1 nuclear factor of activated T-cells, cytoplasmic 2 isoform f
NM_001291170.1 NP_001278099.1 nuclear factor of activated T-cells, cytoplasmic 2 isoform g
NM_001291171.1 NP_001278100.1 nuclear factor of activated T-cells, cytoplasmic 2 isoform h
NM_001291172.1 NP_001278101.1 nuclear factor of activated T-cells, cytoplasmic 2 isoform i
NM_001291173.1 NP_001278102.1 nuclear factor of activated T-cells, cytoplasmic 2 isoform j
NM_001291174.1 NP_001278103.1 nuclear factor of activated T-cells, cytoplasmic 2 isoform k
NM_001291175.1 NP_001278104.1 nuclear factor of activated T-cells, cytoplasmic 2 isoform k
NM_001291176.1 NP_001278105.1 nuclear factor of activated T-cells, cytoplasmic 2 isoform h
NM_001291177.1 NP_001278106.1 nuclear factor of activated T-cells, cytoplasmic 2 isoform g
NM_001291178.1 NP_001278107.1 nuclear factor of activated T-cells, cytoplasmic 2 isoform j
NM_001291179.1 NP_001278108.1 nuclear factor of activated T-cells, cytoplasmic 2 isoform c
NM_010899.3 NP_035029.2 nuclear factor of activated T-cells, cytoplasmic 2 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
8235597 MGI
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
15319455 MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
24161931 MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
12453415 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
8235597 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
24301466 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
8943202 MGI
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
7650004 MGI
enables transcription cis-regulatory region binding IDA
IDA: Inferred from direct assay
19752193 MGI
enables transcription factor binding IPI
IPI: Inferred from physical interaction
24301466 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within calcineurin-NFAT signaling cascade IGI
IGI: Inferred from genetic interaction
18676376 MGI
involved in cartilage development IMP
IMP: Inferred from mutant phenotype
10620601 MGI
acts upstream of or within cellular response to calcium ion IDA
IDA: Inferred from direct assay
23259949 MGI
acts upstream of or within cytokine production IDA
IDA: Inferred from direct assay
15790681 MGI
acts upstream of or within gene expression IMP
IMP: Inferred from mutant phenotype
23259949 MGI
acts upstream of or within lncRNA transcription IMP
IMP: Inferred from mutant phenotype
29475982 MGI
acts upstream of or within myotube cell development IMP
IMP: Inferred from mutant phenotype
18676376 MGI
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
12453415 MGI
involved in positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
19752193 MGI
acts upstream of or within positive regulation of myoblast fusion IMP
IMP: Inferred from mutant phenotype
12757709 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
8235597 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
24301466 MGI
involved in positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
24161931 MGI
acts upstream of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
24301466 MGI
Cellular Component GO Annotation Evidence References Source
located in chromatin IDA
IDA: Inferred from direct assay
24161931 MGI
is active in cytoplasm IDA
IDA: Inferred from direct assay
23259949 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
8668213 MGI
located in cytosol IDA
IDA: Inferred from direct assay
8235597 MGI
is active in nucleus IDA
IDA: Inferred from direct assay
23259949 MGI
located in nucleus IDA
IDA: Inferred from direct assay
8235597 MGI
part of ribonucleoprotein complex IDA
IDA: Inferred from direct assay
21709260 MGI
part of transcription regulator complex IDA
IDA: Inferred from direct assay
8235597 MGI
part of transcription regulator complex IPI
IPI: Inferred from physical interaction
19561615 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

nuclear factor of activated T-cells, cytoplasmic 2

  • NFAT pre-existing subunit

  • T-cell transcription factor NFAT1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09239 NFATC2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-162280 PROTAC BTK Degrader-9 / Unkown
HY-RS09240 NFATC2IP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19067 Nfatc2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25557 Nfatc2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nfatc2 NCBI NCBI:4773