Nfya - nuclear transcription factor-Y alpha Gene

Also Known as Cbf-b; SEZ10; SEZ-10

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18044

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Contributes to transcription cis-regulatory region binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within positive regulation of stem cell proliferation; positive regulation of transcription, DNA-templated; and regulation of stem cell population maintenance. Located in nucleus. Is expressed in several structures, including branchial arch; cerebral cortex; early conceptus; genitourinary system; and hemolymphoid system gland. Orthologous to human NFYA (nuclear transcription factor Y subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]

Nfya Products (16)

mRNA Protein Name
NM_001110832.2 NP_001104302.1 nuclear transcription factor Y subunit alpha isoform a
NM_001347401.2 NP_001334330.1 nuclear transcription factor Y subunit alpha isoform c
NM_001347402.2 NP_001334331.1 nuclear transcription factor Y subunit alpha isoform d
NM_001374803.2 NP_001361732.1 nuclear transcription factor Y subunit alpha isoform e
NM_001413334.1 NP_001400263.1 nuclear transcription factor Y subunit alpha isoform h
NM_001413335.1 NP_001400264.1 nuclear transcription factor Y subunit alpha isoform g
NM_001413336.1 NP_001400265.1 nuclear transcription factor Y subunit alpha isoform f
NM_001413337.1 NP_001400266.1 nuclear transcription factor Y subunit alpha isoform i
NM_001413338.1 NP_001400267.1 nuclear transcription factor Y subunit alpha isoform j
NM_001413339.1 NP_001400268.1 nuclear transcription factor Y subunit alpha isoform k
NM_001413340.1 NP_001400269.1 nuclear transcription factor Y subunit alpha isoform l
NM_001413341.1 NP_001400270.1 nuclear transcription factor Y subunit alpha isoform m
NM_001413342.1 NP_001400271.1 nuclear transcription factor Y subunit alpha isoform n
NM_001413343.1 NP_001400272.1 nuclear transcription factor Y subunit alpha isoform o
NM_001413344.1 NP_001400273.1 nuclear transcription factor Y subunit alpha isoform p
NM_010913.3 NP_035043.1 nuclear transcription factor Y subunit alpha isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
8306889 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
15601870 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
IMP: Inferred from mutant phenotype
15601870 MGI
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
12659851 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
15601870 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10393239 MGI
enables sequence-specific DNA binding IGI
IGI: Inferred from genetic interaction
1698608 MGI
contributes to transcription cis-regulatory region binding IDA
IDA: Inferred from direct assay
15516209 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
12730328 MGI
involved in positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
24030830 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
12659851 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
20861184 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
15601870 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
12659851 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

nuclear transcription factor Y subunit alpha

  • CAAT box DNA-binding protein subunit A

  • nuclear transcription factor Y subunit A

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-128020 ML114 Inhibitor / Unkown
HY-182392 NFYi5 / Unkown
HY-RS09271 NFYA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20307 Nfya Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26815 Nfya Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28777 Nfyb Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nfya NCBI NCBI:4800