Nlk - nemo like kinase Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18099

Summary

Enables several functions, including ATP binding activity; SH2 domain binding activity; and magnesium ion binding activity. Involved in several processes, including intracellular signal transduction; negative regulation of Wnt signaling pathway; and protein phosphorylation. Acts upstream of or within protein autophosphorylation. Located in nucleus. Is expressed in several structures, including early embryo; genitourinary system; nervous system; neural retina; and respiratory system. Orthologous to human NLK (nemo like kinase). [provided by Alliance of Genome Resources, Apr 2022]

Nlk Products (1)

mRNA Protein Name
NM_008702.3 NP_032728.3 serine/threonine-protein kinase NLK

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ATP binding IDA
IDA: Inferred from direct assay
9448268 MGI
enables MAP kinase activity IDA
IDA: Inferred from direct assay
9448268 MGI
enables SH2 domain binding IPI
IPI: Inferred from physical interaction
15004007 MGI
enables magnesium ion binding IDA
IDA: Inferred from direct assay
9448268 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
15082531 MGI
enables protein kinase activity IDA
IDA: Inferred from direct assay
9448268 MGI
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
15004007 MGI
Biological Process GO Annotation Evidence References Source
involved in intracellular signal transduction IDA
IDA: Inferred from direct assay
9448268 MGI
involved in negative regulation of Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
15082531 MGI
involved in peptidyl-threonine phosphorylation IDA
IDA: Inferred from direct assay
17785444 MGI
involved in positive regulation of receptor signaling pathway via STAT IDA
IDA: Inferred from direct assay
15004007 MGI
acts upstream of or within protein autophosphorylation IDA
IDA: Inferred from direct assay
9448268 MGI
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
9448268 MGI
involved in regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
14720327 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
9448268 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

serine/threonine-protein kinase NLK

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-148061 DB1113 99.86% Unkown
HY-148063 DB0614 96.07% Unkown
HY-RS05639 GPI Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09344 NLK Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17483 Nlk Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23184 Gpi Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23941 Nlk Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nlk NCBI NCBI:51701