Slc11a1 - solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 Gene

Also Known as Bcg; Ity; Lsh; ity; Ity1; Nramp; Nramp1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18173

Summary

Enables manganese ion transmembrane transporter activity. Involved in metal ion export. Acts upstream of or within several processes, including cation homeostasis; defense response to Other organism; and positive regulation of macromolecule metabolic process. Located in cytoplasmic vesicle and lysosome. Is expressed in several structures, including brain; gut; hemolymphoid system gland; liver and biliary system; and reproductive system. Human ortholog(s) of this gene implicated in several diseases, including Buruli ulcer disease; autoimmune disease (multiple); inflammatory bowel disease (multiple); leishmaniasis (multiple); and tuberculosis (multiple). Orthologous to human SLC11A1 (solute carrier family 11 member 1). [provided by Alliance of Genome Resources, Apr 2022]

Slc11a1 Products (1)

mRNA Protein Name
NM_013612.2 NP_038640.2 natural resistance-associated macrophage protein 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables iron ion transmembrane transporter activity IDA
IDA: Inferred from direct assay
9730978 MGI
enables manganese ion transmembrane transporter activity IDA
IDA: Inferred from direct assay
9730978 MGI
enables manganese ion transmembrane transporter activity IMP
IMP: Inferred from mutant phenotype
11067873 MGI
enables metal cation:proton antiporter activity IDA
IDA: Inferred from direct assay
9730978 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within L-arginine transmembrane transport IDA
IDA: Inferred from direct assay
8529105 MGI
acts upstream of or within MHC class II biosynthetic process IMP
IMP: Inferred from mutant phenotype
8301134 MGI
acts upstream of or within T cell cytokine production IMP
IMP: Inferred from mutant phenotype
19116231 MGI
acts upstream of or within T cell proliferation involved in immune response IMP
IMP: Inferred from mutant phenotype
9176118 MGI
acts upstream of or within activation of protein kinase activity IMP
IMP: Inferred from mutant phenotype
8301134 MGI
acts upstream of or within antigen processing and presentation of peptide antigen IMP
IMP: Inferred from mutant phenotype
17620357 MGI
acts upstream of or within defense response to Gram-negative bacterium IMP
IMP: Inferred from mutant phenotype
6358358 MGI
acts upstream of or within defense response to bacterium IMP
IMP: Inferred from mutant phenotype
385184 MGI
acts upstream of or within defense response to protozoan IMP
IMP: Inferred from mutant phenotype
606434 MGI
acts upstream of or within establishment of localization in cell IMP
IMP: Inferred from mutant phenotype
11067873 MGI
acts upstream of or within inflammatory response IMP
IMP: Inferred from mutant phenotype
19116231 MGI
acts upstream of or within interleukin-2 production IMP
IMP: Inferred from mutant phenotype
9176118 MGI
acts upstream of or within interleukin-3 production IMP
IMP: Inferred from mutant phenotype
9176118 MGI
acts upstream of or within intracellular iron ion homeostasis IMP
IMP: Inferred from mutant phenotype
11903051 MGI
involved in iron ion transport IDA
IDA: Inferred from direct assay
9730978 MGI
acts upstream of or within mRNA stabilization IMP
IMP: Inferred from mutant phenotype
9009318 MGI
acts upstream of or within macrophage activation IDA
IDA: Inferred from direct assay
8529105 MGI
acts upstream of or within macrophage activation IMP
IMP: Inferred from mutant phenotype
19116231 MGI
involved in manganese ion transport IDA
IDA: Inferred from direct assay
9730978 MGI
acts upstream of or within manganese ion transport IMP
IMP: Inferred from mutant phenotype
11067873 MGI
involved in metal ion transport IDA
IDA: Inferred from direct assay
17932044 MGI
acts upstream of or within multicellular organismal-level iron ion homeostasis IMP
IMP: Inferred from mutant phenotype
9824471 MGI
acts upstream of or within negative regulation of cytokine production IMP
IMP: Inferred from mutant phenotype
16470178 MGI
acts upstream of or within nitrite transport IDA
IDA: Inferred from direct assay
8529105 MGI
acts upstream of or within phagocytosis IMP
IMP: Inferred from mutant phenotype
18045875 MGI
acts upstream of or within positive regulation of T-helper 1 type immune response IMP
IMP: Inferred from mutant phenotype
18984740 MGI
acts upstream of or within positive regulation of cytokine production IMP
IMP: Inferred from mutant phenotype
1541907 MGI
acts upstream of or within positive regulation of dendritic cell antigen processing and presentation IMP
IMP: Inferred from mutant phenotype
18984740 MGI
acts upstream of or within positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
16470178 MGI
acts upstream of or within positive regulation of phagocytosis IMP
IMP: Inferred from mutant phenotype
18456389 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
17620357 MGI
acts upstream of or within positive regulation of type II interferon production IMP
IMP: Inferred from mutant phenotype
18984740 MGI
acts upstream of or within respiratory burst IDA
IDA: Inferred from direct assay
8529105 MGI
acts upstream of or within response to bacterium IMP
IMP: Inferred from mutant phenotype
8490962 MGI
acts upstream of or within response to lipopolysaccharide IDA
IDA: Inferred from direct assay
9261342 MGI
acts upstream of or within response to lipopolysaccharide IMP
IMP: Inferred from mutant phenotype
17620357 MGI
acts upstream of or within response to type II interferon IDA
IDA: Inferred from direct assay
9261342 MGI
acts upstream of type II interferon production IMP
IMP: Inferred from mutant phenotype
18984740 MGI
acts upstream of or within vacuolar acidification IMP
IMP: Inferred from mutant phenotype
9670047 MGI
acts upstream of or within wound healing IMP
IMP: Inferred from mutant phenotype
16470178 MGI
Cellular Component GO Annotation Evidence References Source
located in endosome membrane IDA
IDA: Inferred from direct assay
9034150 MGI
located in late endosome IDA
IDA: Inferred from direct assay
17620357 MGI
located in late endosome IMP
IMP: Inferred from mutant phenotype
9034150 MGI
located in late endosome membrane IDA
IDA: Inferred from direct assay
9730978 MGI
located in lysosomal membrane IDA
IDA: Inferred from direct assay
9730978 MGI
located in lysosome IDA
IDA: Inferred from direct assay
17620357 MGI
located in phagocytic vesicle membrane IDA
IDA: Inferred from direct assay
9034150 MGI
located in phagocytic vesicle membrane IMP
IMP: Inferred from mutant phenotype
11067873 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

natural resistance-associated macrophage protein 1

  • NRAMP 1

  • host resistance locus Bcg/Ity/Lsh

  • solute carrier family 11 member 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12994 SLC11A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19551 Slc11a1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26047 Slc11a1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc11a1 NCBI NCBI:6556