Numb - NUMB endocytic adaptor protein Gene

Also Known as Nb

Species: Mus musculus

Gene Type: protein coding

Gene ID: 18222

Summary

This gene encodes a conserved protein that is distributed asymmetrically during cell division in the developing embryo. The encoded protein participates in cell fate decisions by interacting with the Notch receptor. Loss of function of this gene results in severe defects in neural development and loss of viability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

Numb Products (8)

mRNA	Protein	Name
NM_001136075.3	NP_001129547.1	protein numb homolog isoform 1
NM_001272055.2	NP_001258984.1	protein numb homolog isoform 3
NM_001272056.1	NP_001258985.1	protein numb homolog isoform 4
NM_001411949.1	NP_001398878.1	protein numb homolog isoform 1
NM_001411950.1	NP_001398879.1	protein numb homolog isoform 2
NM_001411951.1	NP_001398880.1	protein numb homolog isoform 4
NM_001411952.1	NP_001398881.1	protein numb homolog isoform 3
NM_010949.3	NP_035079.1	protein numb homolog isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables alpha-catenin binding	IPI IPI: Inferred from physical interaction	17589506	MGI
enables beta-catenin binding	IPI IPI: Inferred from physical interaction	17589506	MGI
enables cadherin binding	IPI IPI: Inferred from physical interaction	17589506	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11922143	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within adherens junction organization	IGI IGI: Inferred from genetic interaction	17589506	MGI
acts upstream of or within axonogenesis	IDA IDA: Inferred from direct assay	15598981	MGI
acts upstream of or within axonogenesis	IMP IMP: Inferred from mutant phenotype	15598981	MGI
acts upstream of or within forebrain development	IMP IMP: Inferred from mutant phenotype	14687546	MGI
involved in lateral ventricle development	IMP IMP: Inferred from mutant phenotype	17174898	MGI
acts upstream of or within nervous system development	IMP IMP: Inferred from mutant phenotype	10841580	MGI
involved in neuroblast division in subventricular zone	IMP IMP: Inferred from mutant phenotype	17174898	MGI
acts upstream of or within neuroblast proliferation	IGI IGI: Inferred from genetic interaction	12410312	MGI
involved in positive regulation of neurogenesis	IMP IMP: Inferred from mutant phenotype	12410312	MGI
involved in regulation of postsynaptic neurotransmitter receptor internalization	IDA IDA: Inferred from direct assay	26621723	MGI
involved in regulation of postsynaptic neurotransmitter receptor internalization	IEP IEP: Inferred from expression pattern	26621723	MGI
involved in regulation of postsynaptic neurotransmitter receptor internalization	IMP IMP: Inferred from mutant phenotype	26621723	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in apical part of cell	IDA IDA: Inferred from direct assay	12361975	MGI
NOT located in apical plasma membrane	IDA IDA: Inferred from direct assay	17589506	MGI
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	17589506	MGI
located in clathrin-coated pit	IDA IDA: Inferred from direct assay	26437238	MGI
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	22174158	MGI
located in early endosome	IDA IDA: Inferred from direct assay	11782429	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	26621723	MGI
is active in glutamatergic synapse	IEP IEP: Inferred from expression pattern	26621723	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	26621723	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
protein numb homolog	numb gene homolog numb homolog

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-119734	Gossypolone		96.28%	Unkown
HY-N7013	Hydroxy-Epsilon-Sanshool		/	Unkown
HY-N7014	Hydroxyl-γ-isosanshool		/	Unkown
HY-RS09681	NUMB Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-N12639	β-Sanshool	Activator	/	Unkown
HY-N12768	Rhodojaponin VI	Inhibitor	/	Unkown
HY-RS19926	Numb Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26428	Numb Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Numb	NCBI	NCBI:8650