Pdcd6ip - programmed cell death 6 interacting protein Gene

Also Known as Aip1; Alix; Eig2; mKIAA1375

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18571

Summary

Enables identical protein binding activity and protein dimerization activity. Involved in several processes, including actomyosin contractile ring assembly; bicellular tight junction assembly; and maintenance of epithelial cell apical/basal polarity. Located in actomyosin; cytosol; and extracellular exosome. Is expressed in hindgut; midgut; rectum; and thymus primordium. Orthologous to human PDCD6IP (programmed cell death 6 interacting protein). [provided by Alliance of Genome Resources, Apr 2022]

Pdcd6ip Products (3)

mRNA Protein Name
NM_001164677.1 NP_001158149.1 programmed cell death 6-interacting protein isoform 1
NM_001164678.1 NP_001158150.1 programmed cell death 6-interacting protein isoform 2
NM_011052.2 NP_035182.2 programmed cell death 6-interacting protein isoform 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
19523902 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
15102471 MGI
enables protein dimerization activity IPI
IPI: Inferred from physical interaction
10200558 MGI
Biological Process GO Annotation Evidence References Source
involved in actomyosin contractile ring assembly IMP
IMP: Inferred from mutant phenotype
27336173 MGI
involved in bicellular tight junction assembly IMP
IMP: Inferred from mutant phenotype
27336173 MGI
involved in extracellular exosome biogenesis IMP
IMP: Inferred from mutant phenotype
25686249 MGI
involved in macroautophagy IMP
IMP: Inferred from mutant phenotype
25686249 MGI
involved in maintenance of epithelial cell apical/basal polarity IMP
IMP: Inferred from mutant phenotype
27336173 MGI
involved in regulation of membrane permeability IMP
IMP: Inferred from mutant phenotype
27336173 MGI
Cellular Component GO Annotation Evidence References Source
located in actomyosin IDA
IDA: Inferred from direct assay
27336173 MGI
located in cytosol IDA
IDA: Inferred from direct assay
9880530 MGI
located in extracellular exosome IDA
IDA: Inferred from direct assay
23523921 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

programmed cell death 6-interacting protein

  • ALG-2-interacting protein 1

  • ALG-2-interacting protein X

  • Alg2-interacting protein 1

  • Alg2-interacting protein X

  • E2f1-inducible protein

Pdcd6ip Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Pdcd6ip Q9WU78 Sdcbp Mus musculus O08992
Y2H
22660413
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10195 PDCD6IP Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pdcd6ip NCBI NCBI:10015