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Pdgfrb - platelet derived growth factor receptor, beta polypeptide Gene

Also Known as Pdgfr; CD140b; PDGFR-1

Species: Mus musculus

Gene Type: protein coding

Gene ID: 18596

About Pdgfrb

Chromosome 18: 61,178,222-61,218,133 forward strand.GRCm39:CM001011.3

This gene has 2 transcripts (splice variants), 247 orthologues, 53 paralogues and is associated with 96 phenotypes. Broad expression in lung adult (RPKM 46.3), subcutaneous fat pad adult (RPKM 35.2) and 24 other tissues.

Summary

Enables platelet-derived growth factor-activated receptor activity and signaling receptor binding activity. Involved in several processes, including positive regulation of intracellular signal transduction; protein phosphorylation; and vasculature development. Acts upstream of or within several processes, including animal organ development; response to ceramide; and ruffle assembly. Located in cell surface; cytoplasm; and ruffle. Is expressed in several structures, including alimentary system; extraembryonic component; genitourinary system; nervous system; and sensory organ. Used to study basal ganglia calcification; infantile myofibromatosis; myeloproliferative neoplasm; and severe nonproliferative diabetic retinopathy. Human ortholog(s) of this gene implicated in basal ganglia calcification; glioblastoma; infantile myofibromatosis; myeloproliferative neoplasm (multiple); and renal cell carcinoma. Orthologous to human PDGFRB (platelet derived growth factor receptor beta). [provided by Alliance of Genome Resources, Apr 2022]

Pdgfrb Products (2)

mRNA	Protein	Name
NM_008809.2	NP_032835.2	platelet-derived growth factor receptor beta isoform 2 precursor
NM_001146268.1	NP_001139740.1	platelet-derived growth factor receptor beta isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables kinase activity	IMP IMP: Inferred from mutant phenotype	12808090	MGI
enables platelet-derived growth factor receptor activity	IDA IDA: Inferred from direct assay	26437238	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	7730365	MGI
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	16456542	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within adrenal gland development	IGI IGI: Inferred from genetic interaction	19056881	MGI
involved in aorta morphogenesis	IGI IGI: Inferred from genetic interaction	19742316	MGI
involved in blood vessel development	IEP IEP: Inferred from expression pattern	10375497	MGI
involved in cardiac myofibril assembly	IGI IGI: Inferred from genetic interaction	11239463	MGI
involved in cell migration involved in coronary angiogenesis	IMP IMP: Inferred from mutant phenotype	14624252	MGI
involved in cell migration involved in vasculogenesis	IMP IMP: Inferred from mutant phenotype	14624252	MGI
acts upstream of or within cellular response to hydrogen peroxide	IMP IMP: Inferred from mutant phenotype	23651497	MGI
involved in embryonic organ development	IEP IEP: Inferred from expression pattern	10375497	MGI
acts upstream of or within excretion	IMP IMP: Inferred from mutant phenotype	17143286	MGI
NOT involved in hemopoiesis	IMP IMP: Inferred from mutant phenotype	11264163	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	17143286	MGI
acts upstream of or within kidney development	IMP IMP: Inferred from mutant phenotype	17143286	MGI
involved in metanephric glomerular capillary formation	IGI IGI: Inferred from genetic interaction	11239463	MGI
involved in metanephric glomerular mesangial cell proliferation involved in metanephros development	IMP IMP: Inferred from mutant phenotype	9693135	MGI
involved in metanephric glomerular mesangium development	IEP IEP: Inferred from expression pattern	9693135	MGI
involved in peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	14624252	MGI
acts upstream of or within platelet-derived growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	17143286	MGI
acts upstream of or within platelet-derived growth factor receptor signaling pathway	IPI IPI: Inferred from physical interaction	26437238	MGI
involved in positive regulation of DNA biosynthetic process	IMP IMP: Inferred from mutant phenotype	19019919	MGI
involved in positive regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	17942966	MGI
involved in positive regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	14624252	MGI
involved in positive regulation of MAP kinase activity	IDA IDA: Inferred from direct assay	17942966	MGI
involved in positive regulation of calcium ion import	IMP IMP: Inferred from mutant phenotype	19019919	MGI
involved in positive regulation of chemotaxis	IDA IDA: Inferred from direct assay	19019919	MGI
involved in positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway	IMP IMP: Inferred from mutant phenotype	19019919	MGI
involved in positive regulation of mitotic nuclear division	IDA IDA: Inferred from direct assay	17942966	MGI
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: Inferred from direct assay	17942966	MGI
involved in positive regulation of reactive oxygen species metabolic process	IMP IMP: Inferred from mutant phenotype	19019919	MGI
involved in positive regulation of smooth muscle cell migration	IGI IGI: Inferred from genetic interaction	19742316	MGI
involved in positive regulation of smooth muscle cell migration	IMP IMP: Inferred from mutant phenotype	10375497	MGI
involved in positive regulation of smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	10375497	MGI
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	14624252	MGI
involved in regulation of actin cytoskeleton organization	IGI IGI: Inferred from genetic interaction	19742316	MGI
acts upstream of or within regulation of peptidyl-tyrosine phosphorylation	IMP IMP: Inferred from mutant phenotype	11940581	MGI
acts upstream of or within response to ceramide	IMP IMP: Inferred from mutant phenotype	23651497	MGI
involved in retina vasculature development in camera-type eye	IGI IGI: Inferred from genetic interaction	11239463	MGI
involved in retina vasculature development in camera-type eye	IMP IMP: Inferred from mutant phenotype	14624252	MGI
acts upstream of or within ruffle assembly	IDA IDA: Inferred from direct assay	26437238	MGI
acts upstream of or within signal transduction	IDA IDA: Inferred from direct assay	11940581	MGI
acts upstream of or within skeletal system morphogenesis	IMP IMP: Inferred from mutant phenotype	17143286	MGI
involved in smooth muscle cell chemotaxis	IGI IGI: Inferred from genetic interaction	19742316	MGI
acts upstream of or within smooth muscle tissue development	IMP IMP: Inferred from mutant phenotype	17143286	MGI
acts upstream of or within tissue homeostasis	IMP IMP: Inferred from mutant phenotype	17143286	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cell surface	IDA IDA: Inferred from direct assay	24029230	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	22027834	MGI
located in ruffle	IDA IDA: Inferred from direct assay	26437238	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Pdgfrb Protein Structure

PKc_like

0
200
400
600
800
1000
1098 a.a.

Protein Preferred Names	Protein Names
platelet-derived growth factor receptor beta	CD140 antigen-like family member B PDGF beta chain PDGF-R-beta PDGFR-beta beta platelet-derived growth factor receptor beta-type platelet-derived growth factor receptor platelet-derived growth factor receptor 1

Pdgfrb Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P810772	Phospho-PDGFR beta (Tyr740) Antibody (YA10015)	WB, ICC/IF	Mouse, Rat

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-132166	Velzatinib	Inhibitor	99.40%	Unkown
HY-15813	FIIN-1	Inhibitor	99.04%	Unkown
HY-RS10257	PDGFRB Human Pre-designed siRNA Set A		/	Unkown
HY-115541	BRD4-IN-41	Inhibitor	/	Unkown
HY-RS10258	Pdgfrb Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS10259	Pdgfrb Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174548	Human PDGFRB mRNA		/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P992326	BOT1711	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pdgfrb	NCBI	NCBI:5159