Penk - preproenkephalin Gene

Also Known as ENK; PPA; Penk1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18619

Summary

Predicted to enable Opioid Receptor binding activity. Acts upstream of or within several processes, including behavioral fear response; sensory perception of pain; and startle response. Predicted to be located in several cellular components, including cell body fiber; perikaryon; and symmetric synapse. Predicted to be active in several cellular components, including axon terminus; dendrite; and neuronal cell body. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Orthologous to human PENK (proenkephalin). [provided by Alliance of Genome Resources, Apr 2022]

Penk Products (2)

mRNA Protein Name
NM_001002927.3 NP_001002927.1 proenkephalin-A precursor
NM_001348209.1 NP_001335138.1 proenkephalin-A precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables opioid peptide activity IDA
IDA: Inferred from direct assay
6933569 MGI
enables opioid receptor binding IDA
IDA: Inferred from direct assay
6933569 MGI
enables receptor ligand activity IDA
IDA: Inferred from direct assay
6933569 MGI
Biological Process GO Annotation Evidence References Source
involved in G protein-coupled opioid receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
6933569 MGI
acts upstream of or within aggressive behavior IMP
IMP: Inferred from mutant phenotype
8849726 MGI
acts upstream of or within behavioral fear response IMP
IMP: Inferred from mutant phenotype
11172058 MGI
acts upstream of or within locomotory behavior IMP
IMP: Inferred from mutant phenotype
8849726 MGI
involved in regulation of long-term synaptic depression IDA
IDA: Inferred from direct assay
35201898 MGI
acts upstream of or within response to bacterium IEP
IEP: Inferred from expression pattern
23012479 MGI
acts upstream of or within sensory perception of pain IMP
IMP: Inferred from mutant phenotype
8849726 MGI
acts upstream of or within startle response IMP
IMP: Inferred from mutant phenotype
8849726 MGI
involved in transmission of nerve impulse IMP
IMP: Inferred from mutant phenotype
6933569 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

proenkephalin-A

  • preproenkephalin 1

  • spermatogenic-specific proenkephalin

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS19363 Penk Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10326 PENK Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25855 Penk Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Penk NCBI NCBI:5179