Pfkfb1 - 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 Gene

Also Known as PFK/FBPase 1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18639

Summary

Predicted to enable several functions, including 6-phosphofructo-2-kinase activity; anion binding activity; and fructose-2,6-bisphosphate 2-phosphatase activity. Predicted to be involved in carbohydrate phosphorylation; fructose 2,6-bisphosphate metabolic process; and positive regulation of Glucokinase activity. Predicted to act upstream of or within phosphorylation. Predicted to be part of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex. Predicted to be active in cytosol. Orthologous to human PFKFB1 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1). [provided by Alliance of Genome Resources, Apr 2022]

Pfkfb1 Products (8)

mRNA Protein Name
NM_001374170.1 NP_001361099.1 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 isoform 2
NM_001374171.1 NP_001361100.1 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 isoform 2
NM_001374172.1 NP_001361101.1 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 isoform 2
NM_001374173.1 NP_001361102.1 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 isoform 1
NM_001374175.1 NP_001361104.1 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 isoform 3
NM_001411763.1 NP_001398692.1 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 isoform 2
NM_001411764.1 NP_001398693.1 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 isoform 4
NM_008824.4 NP_032850.1 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables fructose-2,6-bisphosphate 2-phosphatase activity IGI
IGI: Inferred from genetic interaction
16155866 MGI
Biological Process GO Annotation Evidence References Source
involved in negative regulation of glycolytic process through fructose-6-phosphate IGI
IGI: Inferred from genetic interaction
16155866 MGI
involved in negative regulation of glycolytic process through fructose-6-phosphate IMP
IMP: Inferred from mutant phenotype
15331593 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1

  • 6PF-2-K/Fru-2,6-P2ase liver isozyme

  • PFK-2/FBPase-2 gene A

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-101972 AZ-PFKFB3-67 Inhibitor 97.03% Unkown
HY-101971 AZ PFKFB3 26 Inhibitor 99.23% Unkown
HY-178367 PFKFB4-IN-1 99.91% Unkown
HY-101972A AZ-PFKFB3-67 quarterhydrate Inhibitor 99.0% Unkown
HY-184148 PFKFB3-IN-3 Inhibitor / Unkown
HY-RS10361 PFKFB1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20187 Pfkfb1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26691 Pfkfb1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pfkfb1 NCBI NCBI:5207