Pfkm - phosphofructokinase, muscle Gene

Also Known as Pfk4; Pfka; Pfkx; PFK-A; PFK-M; Pfk-4; ATP-PFK

Species: Mus musculus

Gene Type: protein coding

Gene ID: 18642

Summary

Enables 6-phosphofructokinase activity and identical protein binding activity. Acts upstream of or within several processes, including glycogen catabolic process; glycolytic process through glucose-6-phosphate; and positive regulation of Insulin secretion. Located in cytosol and sperm principal piece. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and musculoskeletal system. Used to study glycogen storage disease VII. Human ortholog(s) of this gene implicated in glycogen storage disease VII. Orthologous to human PFKM (phosphofructokinase, muscle). [provided by Alliance of Genome Resources, Apr 2022]

Pfkm Products (4)

mRNA	Protein	Name
NM_001163487.1	NP_001156959.1	ATP-dependent 6-phosphofructokinase, muscle type
NM_001163488.1	NP_001156960.1	ATP-dependent 6-phosphofructokinase, muscle type
NM_001357688.1	NP_001344617.1	ATP-dependent 6-phosphofructokinase, muscle type
NM_021514.4	NP_067489.3	ATP-dependent 6-phosphofructokinase, muscle type

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables 6-phosphofructokinase activity	IDA IDA: Inferred from direct assay	2521854	MGI
enables 6-phosphofructokinase activity	IMP IMP: Inferred from mutant phenotype	17595219	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	19889946	MGI
enables phosphofructokinase activity	IDA IDA: Inferred from direct assay	11785984	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in canonical glycolysis	IDA IDA: Inferred from direct assay	4275392	MGI
involved in canonical glycolysis	IGI IGI: Inferred from genetic interaction	27760309	MGI
acts upstream of or within canonical glycolysis	IMP IMP: Inferred from mutant phenotype	19696889	MGI
acts upstream of or within glucose homeostasis	IMP IMP: Inferred from mutant phenotype	17595219	MGI
acts upstream of or within glycogen catabolic process	IMP IMP: Inferred from mutant phenotype	19696889	MGI
acts upstream of or within glycolysis from storage polysaccharide through glucose-1-phosphate	IMP IMP: Inferred from mutant phenotype	19696889	MGI
acts upstream of or within glycolytic process through fructose-6-phosphate	IDA IDA: Inferred from direct assay	2521854	MGI
involved in glycolytic process through fructose-6-phosphate	IDA IDA: Inferred from direct assay	19889946	MGI
acts upstream of or within glycolytic process through fructose-6-phosphate	IMP IMP: Inferred from mutant phenotype	17595219	MGI
acts upstream of or within positive regulation of insulin secretion	IMP IMP: Inferred from mutant phenotype	17595219	MGI

Cellular Component GO Annotation	Evidence	References	Source
is active in cytosol	IDA IDA: Inferred from direct assay	2521854	MGI
located in cytosol	IDA IDA: Inferred from direct assay	2521854	MGI
located in sperm principal piece	IDA IDA: Inferred from direct assay	19889946	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
ATP-dependent 6-phosphofructokinase, muscle type	6-phosphofructokinase type A 6-phosphofructokinase, muscle type phosphofructo-1-kinase isozyme A phosphofructokinase 1 phosphofructokinase 4 phosphofructokinase M variant 3/4 phosphofructokinase, polypeptide X phosphofructokinase-1 A isozyme phosp

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS18964	Pfkm Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS10366	PFKM Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25454	Pfkm Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pfkm	NCBI	NCBI:5213