Pgr - progesterone receptor Gene

Also Known as PR; PR-A; PR-B; NR3C3; 9930019P03Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18667

About Pgr

Chromosome 9: 8,899,834-8,968,612 forward strand.GRCm39:CM001002.3

This gene has 4 transcripts (splice variants), 193 orthologues, 8 paralogues and is associated with 51 phenotypes. Biased expression in subcutaneous fat pad adult (RPKM 5.5), ovary adult (RPKM 4.9) and 6 other tissues.

Summary

This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. [provided by RefSeq, Sep 2015]

Pgr Products (1)

mRNA Protein Name
NM_008829.2 NP_032855.2 progesterone receptor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables nuclear receptor activity IMP
IMP: Inferred from mutant phenotype
14681235 MGI
enables nuclear steroid receptor activity IDA
IDA: Inferred from direct assay
16176985 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
8978696 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within epithelial cell maturation IMP
IMP: Inferred from mutant phenotype
14765981 MGI
acts upstream of or within glandular epithelial cell maturation IMP
IMP: Inferred from mutant phenotype
14765981 MGI
acts upstream of or within lung alveolus development IMP
IMP: Inferred from mutant phenotype
24190884 MGI
acts upstream of or within mammary gland development IMP
IMP: Inferred from mutant phenotype
12897242 MGI
acts upstream of or within ovulation from ovarian follicle IMP
IMP: Inferred from mutant phenotype
12897242 MGI
acts upstream of or within paracrine signaling IMP
IMP: Inferred from mutant phenotype
24190884 MGI
acts upstream of or within progesterone receptor signaling pathway IDA
IDA: Inferred from direct assay
16176985 MGI
acts upstream of or within regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
14681235 MGI
acts upstream of or within regulation of epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
12897242 MGI
acts upstream of or within tertiary branching involved in mammary gland duct morphogenesis IMP
IMP: Inferred from mutant phenotype
10733525 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Pgr Protein Structure

Prog_receptor

Prog_receptor: pfam02161 (0 - 556)

NR_DBD_GR_PR

NR_DBD_GR_PR: cd07172 (555 - 632)

NR_LBD_PR

NR_LBD_PR: cd07074 (678 - 925)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 926 a.a.
Protein Preferred Names Protein Names

progesterone receptor

  • nuclear receptor subfamily 3 group C member 3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10396 PGR Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10397 Pgr Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10398 Pgr Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-164997 15-keto Prostaglandin F1α / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pgr NCBI NCBI:5241