Polg - polymerase (DNA directed), gamma Gene

Also Known as PolgA

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18975

Summary

Enables exonuclease activity. Acts upstream of or within aging and mitochondrial DNA replication. Located in mitochondrial inner membrane. Is expressed in several structures, including early conceptus and secondary oocyte. Used to study bipolar disorder; mood disorder; and myelodysplastic syndrome. Human ortholog(s) of this gene implicated in several diseases, including mitochondrial DNA depletion syndrome (multiple); mitochondrial myopathy (multiple); neurodegenerative disease (multiple); ovarian disease (multiple); and sensory ataxic neuropathy, dysarthria, and ophthalmoparesis. Orthologous to human POLG (DNA Polymerase gamma, catalytic subunit). [provided by Alliance of Genome Resources, Apr 2022]

Polg Products (3)

mRNA Protein Name
NM_001360095.1 NP_001347024.1 DNA polymerase subunit gamma-1 isoform 2
NM_001360096.1 NP_001347025.1 DNA polymerase subunit gamma-1 isoform 3
NM_017462.3 NP_059490.2 DNA polymerase subunit gamma-1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables exonuclease activity IDA
IDA: Inferred from direct assay
15164064 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
16327803 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within determination of adult lifespan IMP
IMP: Inferred from mutant phenotype
15164064 MGI
acts upstream of or within mitochondrial DNA replication IMP
IMP: Inferred from mutant phenotype
15888483 MGI
involved in mitochondrial DNA replication IMP
IMP: Inferred from mutant phenotype
26095671 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

DNA polymerase subunit gamma-1

  • DNA polymerase gamma subunit 1 (Mitochondrial DNA polymerase catalytic subunit) (PolG-alpha)

  • Pol gamma

  • mitochondrial DNA polymerase catalytic subunit

  • mitochondrial DNA polymerase gamma

  • mitochondrial polymerase gamma

  • polG-alpha

  • polymerase, gamma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-174216 PZL-A Activator 99.72% Unkown
HY-RS10829 POLG Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10830 POLG2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19370 Polg Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22735 Polg2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25862 Polg Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29249 Polg2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Polg NCBI NCBI:5428