Prkar1a - protein kinase, cAMP dependent regulatory, type I, alpha Gene

Also Known as Tse1; Tse-1; RIalpha; 1300018C22Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 19084

Summary

The encoded protein is a regulatory subunit of the cAMP-dependent protein kinase (PKA) complex, which is responsible for transducing most of the cAMP signals in eukaryotic cells. The inactive PKA complex contains two regulatory and two catalytic subunits. Binding of cAMP dissociates the complex, allowing monomeric catalytic subunits to phosphorylate cytosolic proteins or induce gene expression in the nucleus. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2015]

Prkar1a Products (8)

mRNA	Protein	Name
NM_001313973.2	NP_001300902.1	cAMP-dependent protein kinase type I-alpha regulatory subunit
NM_001313974.2	NP_001300903.1	cAMP-dependent protein kinase type I-alpha regulatory subunit
NM_001313975.2	NP_001300904.1	cAMP-dependent protein kinase type I-alpha regulatory subunit
NM_001313976.2	NP_001300905.1	cAMP-dependent protein kinase type I-alpha regulatory subunit
NM_001362677.1	NP_001349606.1	cAMP-dependent protein kinase type I-alpha regulatory subunit
NM_001373912.1	NP_001360841.1	cAMP-dependent protein kinase type I-alpha regulatory subunit
NM_001373913.1	NP_001360842.1	cAMP-dependent protein kinase type I-alpha regulatory subunit
NM_021880.4	NP_068680.1	cAMP-dependent protein kinase type I-alpha regulatory subunit

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables cAMP-dependent protein kinase inhibitor activity	IMP IMP: Inferred from mutant phenotype	27803029	MGI
enables cAMP-dependent protein kinase regulator activity	IDA IDA: Inferred from direct assay	7775586	MGI
enables cAMP-dependent protein kinase regulator activity	IGI IGI: Inferred from genetic interaction	12004056	MGI
enables cAMP-dependent protein kinase regulator activity	IMP IMP: Inferred from mutant phenotype	12004056	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	9852104	MGI
enables protein kinase A catalytic subunit binding	IPI IPI: Inferred from physical interaction	30026308	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	9075801	MGI
acts upstream of or within cardiac muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	18316483	MGI
involved in cellular response to glucagon stimulus	IMP IMP: Inferred from mutant phenotype	32735622	MGI
acts upstream of or within heart development	IMP IMP: Inferred from mutant phenotype	18316483	MGI
acts upstream of or within mesoderm formation	IMP IMP: Inferred from mutant phenotype	12004056	MGI
acts upstream of or within negative regulation of protein kinase activity	IMP IMP: Inferred from mutant phenotype	18316483	MGI
involved in positive regulation of insulin secretion	IMP IMP: Inferred from mutant phenotype	9075801	MGI
acts upstream of or within sarcomere organization	IMP IMP: Inferred from mutant phenotype	18316483	MGI

Cellular Component GO Annotation	Evidence	References	Source
part of cAMP-dependent protein kinase complex	IDA IDA: Inferred from direct assay	21502359	MGI
located in centrosome	IDA IDA: Inferred from direct assay	30026308	MGI
is active in cytoplasm	IDA IDA: Inferred from direct assay	21502359	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	30026308	MGI
is active in cytosol	IDA IDA: Inferred from direct assay	33185461	MGI
is active in glutamatergic synapse	EXP EXP: Inferred from Experiment	24413018	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	24413018	MGI
located in multivesicular body	IDA IDA: Inferred from direct assay	21502359	MGI
located in neuromuscular junction	IDA IDA: Inferred from direct assay	8794865	MGI
located in sperm head-tail coupling apparatus	IDA IDA: Inferred from direct assay	30026308	MGI
is active in synapse	EXP EXP: Inferred from Experiment	24413018	MGI
is active in synapse	IDA IDA: Inferred from direct assay	24413018	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
cAMP-dependent protein kinase type I-alpha regulatory subunit	protein kinase, cAMP dependent regulatory, type 1, alpha

Prkar1a Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Prkar1a	Q9DBC7	Bcl2l11	Mus musculus	O54918-1	Anti Tag CoIP	21151042

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant Prkar1a Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75982	PRKAR1A Protein, Mouse (sf9, His)	Q9DBC7 (M1-V381)	≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11112	PRKAR1A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17722	Prkar1a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24187	Prkar1a Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Prkar1a	NCBI	NCBI:5573