Lgmn - legumain Gene

Also Known as AEP; Prsc1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 19141

Summary

This gene encodes a member of the cysteine peptidase family C13 that plays an important role in the endosome/lysosomal degradation system. The encoded inactive preproprotein undergoes autocatalytic removal of the C-terminal inhibitory propeptide to generate the active endopeptidase that cleaves protein substrates on the C-terminal side of asparagine residues. Mice lacking the encoded protein exhibit defects in the lysosomal processing of proteins resulting in their accumulation in the lysosomes, and develop symptoms resembling hemophagocytic lymphohistiocytosis. [provided by RefSeq, Aug 2016]

Lgmn Products (2)

mRNA Protein Name
NM_001378875.1 NP_001365804.1 legumain preproprotein
NM_011175.4 NP_035305.1 legumain preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cysteine-type endopeptidase activity IDA
IDA: Inferred from direct assay
9742219 MGI
enables cysteine-type endopeptidase activity IMP
IMP: Inferred from mutant phenotype
25326800 MGI
enables peptidase activity IMP
IMP: Inferred from mutant phenotype
12775715 MGI
Biological Process GO Annotation Evidence References Source
involved in associative learning IGI
IGI: Inferred from genetic interaction
25326800 MGI
involved in dendritic spine organization IGI
IGI: Inferred from genetic interaction
25326800 MGI
involved in memory IGI
IGI: Inferred from genetic interaction
25326800 MGI
involved in negative regulation of ERBB signaling pathway IMP
IMP: Inferred from mutant phenotype
21292981 MGI
acts upstream of or within negative regulation of multicellular organism growth IMP
IMP: Inferred from mutant phenotype
12775715 MGI
involved in positive regulation of long-term synaptic potentiation IGI
IGI: Inferred from genetic interaction
25326800 MGI
involved in protein maturation IDA
IDA: Inferred from direct assay
37347855 MGI
acts upstream of or within proteolysis IDA
IDA: Inferred from direct assay
12775715 MGI
involved in proteolysis IDA
IDA: Inferred from direct assay
9742219 MGI
acts upstream of or within proteolysis IMP
IMP: Inferred from mutant phenotype
18374643 MGI
involved in proteolysis involved in protein catabolic process IMP
IMP: Inferred from mutant phenotype
17350006 MGI
involved in receptor catabolic process IMP
IMP: Inferred from mutant phenotype
21292981 MGI
involved in renal system process IMP
IMP: Inferred from mutant phenotype
21292981 MGI
acts upstream of or within response to acidic pH IMP
IMP: Inferred from mutant phenotype
18374643 MGI
involved in response to acidic pH IMP
IMP: Inferred from mutant phenotype
25326800 MGI
Cellular Component GO Annotation Evidence References Source
located in apical part of cell IDA
IDA: Inferred from direct assay
12775715 MGI
located in late endosome IDA
IDA: Inferred from direct assay
12775715 MGI
located in lysosome IDA
IDA: Inferred from direct assay
9742219 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

legumain

  • asparaginyl endopeptidase

  • preprolegumain

  • protease, cysteine, 1

Recombinant Lgmn Proteins

Cat. No. Product Name Accession Purity
HY-P70216A Legumain Protein, Mouse (HEK293, C-His) O89017 (V18-Y435) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07617 LGMN Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17268 Lgmn Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23722 Lgmn Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lgmn NCBI NCBI:5641