1. Gene
  2. LGMN - legumain Gene

LGMN - legumain Gene

Homo sapiens

Also known as AEP; LGMN1; PRSC1

Gene ID: 5641 | Gene type: protein coding

About LGMN

Cytogenetic location: 14q32.12 Genomic coordinates (GRCh38): 14:92,703,809-92,748,627 (from NCBI)

This gene has 19 transcripts (splice variants), 210 orthologues and 1 paralogue. Ubiquitous expression in placenta (RPKM 135.7), spleen (RPKM 98.7) and 23 other tissues.

Summary

This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This Enzyme may be involved in the processing of Bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active Enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined. These two variants encode the same isoform. [provided by RefSeq, Jul 2008]

LGMN Products(4)

mRNA Protein Name
NM_001008530.3 NP_001008530.1 legumain isoform 1 preproprotein
NM_001363696.2 NP_001350625.1 legumain isoform 2 precursor
NM_001363699.2 NP_001350628.1 legumain isoform 3 precursor
NM_005606.7 NP_005597.3 legumain isoform 1 preproprotein

LGMN Protein Structure

Peptidase_C13

Peptidase_C13: Peptidase C13 family (29 - 285)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 433 a.a.
Protein Preferred Names Protein Names

legumain

asparaginyl endopeptidase

Recombinant LGMN Proteins

Cat. No. Product Name Accession Purity
HY-P70897 Legumain Protein, Human (HEK293, His) AAH03061.1 (I18-Y433) ≥95%

Related Diseases

Diseases Alias
Schistosomiasis

Katayama Fever

Bilharzia

Bilharziasis

Schistosomiasis Mansoni

Blood Fluke

Schistosoma Mansoni Infection

Snail Fever

Acute Schistosomiasis

Schistosomiasis Manson

Schistosomiasis Due To Schistosoma Mansoni [Intestinal Schistosomiasis]

Intestinal Schistosomiasis Nos

Intestinal Schistosomiasis

Egyptian Splenomegaly

Bilharziasis Of Intestine

Schistosomal Dysentery

Schistosomiasis Of Colon

Asiatic Schistosomiasis

Eastern Schistosomiasis

Schistosoma Japonicum Infection

Schistosomiasis Japonicum

Katayama Disease

Katayama Syndrome

Oriental Schistosomiasis

Aneruptive Fever

Rickettsia Helvetica Spotted Fever

Cerebral Amyloid Angiopathy, Cst3-Related

Cerebral Amyloid Angiopathy

Hereditary Cerebral Hemorrhage With Amyloidosis

Hchwa

Hereditary Cystatin C Amyloid Angiopathy

Cerebral Amyloid Angiopathy, Familial

Amyloidosis, Cerebroarterial, Icelandic Type

Amyloidosis Vi

Cerebral Hemorrhage, Hereditary, With Amyloidosis

Cst3-Related Cerebral Amyloid Angiopathy

Cerebral Hemorrhage, Hereditary, With Amyloidosis, Icelandic Variant

Hereditary Cerebral Hemorrhage With Amyloidosis, Icelandic Variant

Caa, Familial

Cerebral Amyloid Angiopathy, Genetic

Acys Amyloidosis

Cst3-Related Amyloidosis

Cystatin Amyloidosis

Hchwa, Icelandic Type

Hereditary Cerebral Hemorrhage With Amyloidosis, Icelandic Type

Amyloidosis 6

AMYL6

Acys

Caa

Cerebral Amyloid Angiopathy Cst3-Related

Cerebroarterial Amyloidosis Icelandic Type

Cystatin C Amyloidosis

Hccaa

Hchwai

Hchwa-I

Hereditary Cerebral Hemorrhage With Amyloidosis Icelandic Type

Cerebral Amyloid Angiopathy Familial

Angiopathy, Amyloid, Cerebral, Cst3-Related

Hereditary Cerebral Amyloid Angiopathy, Icelandic Type

Familial Cerebral Amyloid Angiopathy

Cerebral Amyloid Angiopathy, Hereditary

Keratosis Follicularis Spinulosa Decalvans, Autosomal Dominant

Autosomal Dominant Keratosis Follicularis Spinulosa Decalvans

KFSD

Trichomoniasis

Trichomonas Infection

Trichomonas Infections

Disease Due To Trichomonadidae

Infection By Trichomonas

Trichomonadosis

Trichomonas Pruritus

Trichomonosis

Tricomoniasis

Tick Infestation

Tick Infestations

Robinow Syndrome, Autosomal Recessive 1

Robinow Syndrome, Autosomal Recessive

Autosomal Recessive Robinow Syndrome

Covesdem Syndrome

RRS1

Costovertebral Segmentation Defect-Mesomelia Syndrome

Rrs

Costovertebral Segmentation Defect With Mesomelia, Formerly

Covesdem Syndrome, Formerly

Costovertebral Segmentation Defect With Mesomelia

Robinow Syndrome Autosomal Recessive With Aplasia/Hypoplasia Of Phalanges And Metacarpals/Metatarsals

Robinow Syndrome Autosomal Recessive With Brachy-Syn-Polydactyly

Robinow Syndrome, Autosomal Recessive, With Aplasia/Hypoplasia Of Phalanges And Metacarpals/Metatarsals

Robinow Syndrome, Autosomal Recessive, With Brachy-Syn-Polydactyly

Robinow, Autosomal Recessive Syndrome, Type 1

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Bos taurus LGMN VGNC VGNC:30860
Macaca mulatta LGMN VGNC VGNC:74274
Canis familiaris LGMN VGNC VGNC:42654
Felis catus LGMN VGNC VGNC:69086
Rattus norvegicus LGMN RGD RGD:619832
Mus musculus LGMN MGD MGI:1330838
Susscrofa domestica LGMN NCBI
Others LGMN NCBI