Ptbp1 - polypyrimidine tract binding protein 1 Gene

Also Known as Ptb; PTB2; PTB3; PTB4; pPTB; HNRPI; PTB-1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 19205

Summary

Enables RNA binding activity. Involved in negative regulation of mRNA splicing, via spliceosome and negative regulation of neuron differentiation. Acts upstream of with a negative effect on gene expression. Acts upstream of or within neurogenesis and positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including brain; genitourinary system; hemolymphoid system gland; liver; and sensory organ. Orthologous to human PTBP1 (polypyrimidine tract binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Ptbp1 Products (8)

mRNA Protein Name
NM_001077363.3 NP_001070831.1 polypyrimidine tract-binding protein 1 isoform 1
NM_001283013.2 NP_001269942.1 polypyrimidine tract-binding protein 1 isoform 3
NM_001407385.1 NP_001394314.1 polypyrimidine tract-binding protein 1 isoform 4
NM_001407387.1 NP_001394316.1 polypyrimidine tract-binding protein 1 isoform 4
NM_001407389.1 NP_001394318.1 polypyrimidine tract-binding protein 1 isoform 5
NM_001407391.1 NP_001394320.1 polypyrimidine tract-binding protein 1 isoform 6
NM_001407393.1 NP_001394322.1 polypyrimidine tract-binding protein 1 isoform 6
NM_008956.4 NP_032982.2 polypyrimidine tract-binding protein 1 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA binding IPI
IPI: Inferred from physical interaction
25800779 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
16051233 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of negative effect gene expression IGI
IGI: Inferred from genetic interaction
25800779 MGI
acts upstream of negative effect gene expression IMP
IMP: Inferred from mutant phenotype
25800779 MGI
involved in negative regulation of mRNA splicing, via spliceosome IDA
IDA: Inferred from direct assay
17679093 MGI
acts upstream of or within negative regulation of mRNA splicing, via spliceosome IMP
IMP: Inferred from mutant phenotype
23636947 MGI
involved in negative regulation of neuron differentiation IDA
IDA: Inferred from direct assay
17679093 MGI
acts upstream of or within neurogenesis IMP
IMP: Inferred from mutant phenotype
25800779 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
24530304 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
10716735 MGI
is active in nucleus IPI
IPI: Inferred from physical interaction
25800779 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

polypyrimidine tract-binding protein 1

  • heterogeneous nuclear ribonucleoprotein I

  • hnRNP I

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P5960 PTBP1-RNA-binding inhibitor P6 TFA 98.59% Unkown
HY-167832 PT109 99.20% Unkown
HY-RS11351 PTBP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17773 Ptbp1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24240 Ptbp1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ptbp1 NCBI NCBI:5725