Mtnr1b - melatonin receptor 1B Gene

Also Known as Mt2; Mel1b-r

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 192646

About Mtnr1b

Primary_assembly 8: 12,638,219-12,652,737 reverse strand.mRatBN7.2:CM026981.1

This gene has 1 transcript (splice variant), 106 orthologues, 50 paralogues and is associated with 5 phenotypes. Low expression observed in reference dataset.

Summary

Predicted to enable G protein-coupled receptor activity. Involved in several processes, including negative regulation of cGMP-mediated signaling; negative regulation of transport; and regulation of transmission of nerve impulse. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Used to study acute pancreatitis. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human MTNR1B (Melatonin Receptor 1B). [provided by Alliance of Genome Resources, Apr 2022]

Mtnr1b Products (1)

mRNA Protein Name
NM_001393841.1 NP_001380770.1 melatonin receptor type 1B precursor

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in camera-type eye development IEP
IEP: Inferred from expression pattern
12890503 RGD
involved in negative regulation of cGMP-mediated signaling IMP
IMP: Inferred from mutant phenotype
18363673 RGD
involved in negative regulation of cytosolic calcium ion concentration IMP
IMP: Inferred from mutant phenotype
14675130 RGD
involved in negative regulation of delayed rectifier potassium channel activity IDA
IDA: Inferred from direct assay
14962062 RGD
involved in negative regulation of insulin secretion IMP
IMP: Inferred from mutant phenotype
18363673 RGD
involved in negative regulation of neuron apoptotic process IDA
IDA: Inferred from direct assay
14962062 RGD
involved in negative regulation of transmission of nerve impulse IMP
IMP: Inferred from mutant phenotype
15082174 RGD
involved in negative regulation of vasoconstriction IMP
IMP: Inferred from mutant phenotype
10199853 RGD
involved in positive regulation of circadian rhythm IDA
IDA: Inferred from direct assay
12643943 RGD
involved in positive regulation of circadian sleep/wake cycle, non-REM sleep IDA
IDA: Inferred from direct assay
19429170 RGD
involved in positive regulation of circadian sleep/wake cycle, non-REM sleep IMP
IMP: Inferred from mutant phenotype
22171046 RGD
involved in positive regulation of transmission of nerve impulse IDA
IDA: Inferred from direct assay
22171046 RGD
involved in regulation of neuronal action potential IMP
IMP: Inferred from mutant phenotype
21094224 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Mtnr1b Protein Structure

7tm_GPCRs

7tm_GPCRs: cl28897 (40 - 318)

7tm_GPCRs

7tm_GPCRs: cd14964 (42 - 66)

7tm_GPCRs

7tm_GPCRs: cd14964 (75 - 97)

7tm_GPCRs

7tm_GPCRs: cd14964 (113 - 135)

7tm_GPCRs

7tm_GPCRs: cd14964 (158 - 174)

7tm_GPCRs

7tm_GPCRs: cd14964 (197 - 220)

7tm_GPCRs

7tm_GPCRs: cd14964 (249 - 271)

7tm_GPCRs

7tm_GPCRs: cd14964 (286 - 311)

  • 0
  • 100
  • 200
  • 300
  • 364 a.a.
Protein Preferred Names Protein Names

melatonin receptor type 1B

  • mel-1B-R

  • mel1b melatonin receptor

  • mel1b receptor

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08806 MTNR1B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08807 Mtnr1b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08808 Mtnr1b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mtnr1b NCBI NCBI:4544