Pla2g15 - phospholipase A2, group XV Gene

Also Known as ACS; LLPL; Lpla2; Lypla3

Species: Mus musculus

Gene Type: protein coding
Gene ID: 192654

Summary

Enables acylglycerol O-acyltransferase activity; calcium-independent Phospholipase A2 activity; and Phospholipase A1 activity. Involved in diacylglycerol biosynthetic process; phosphatidylcholine catabolic process; and phosphatidylethanolamine catabolic process. Acts upstream of or within ceramide metabolic process. Located in extracellular space and lysosome. Is expressed in several structures, including adrenal gland; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human PLA2G15 (Phospholipase A2 group XV). [provided by Alliance of Genome Resources, Apr 2022]

Pla2g15 Products (2)

mRNA Protein Name
NM_001357319.1 NP_001344248.1 phospholipase A2 group XV isoform 2 precursor
NM_133792.3 NP_598553.1 phospholipase A2 group XV isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables O-acyltransferase activity IDA
IDA: Inferred from direct assay
16837646 MGI
enables acylglycerol O-acyltransferase activity IDA
IDA: Inferred from direct assay
17626977 MGI
enables calcium-independent phospholipase A2 activity IDA
IDA: Inferred from direct assay
11790796 MGI
NOT enables lysophospholipase activity IDA
IDA: Inferred from direct assay
11790796 MGI
enables phospholipase A1 activity IDA
IDA: Inferred from direct assay
16837646 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within ceramide metabolic process IDA
IDA: Inferred from direct assay
11790796 MGI
involved in ceramide metabolic process IDA
IDA: Inferred from direct assay
16837646 MGI
involved in diacylglycerol biosynthetic process IDA
IDA: Inferred from direct assay
17626977 MGI
involved in glycerophospholipid metabolic process IDA
IDA: Inferred from direct assay
20410020 MGI
involved in phosphatidylcholine catabolic process IDA
IDA: Inferred from direct assay
16837646 MGI
involved in phosphatidylcholine catabolic process IMP
IMP: Inferred from mutant phenotype
16880524 MGI
involved in phosphatidylethanolamine catabolic process IDA
IDA: Inferred from direct assay
16837646 MGI
involved in phosphatidylethanolamine catabolic process IMP
IMP: Inferred from mutant phenotype
16880524 MGI
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
20410020 MGI
located in lysosome IDA
IDA: Inferred from direct assay
29514215 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

phospholipase A2 group XV

  • 1-O-acylceramide synthase

  • LCAT-like lysophospholipase

  • group XV phospholipase A2

  • lysophospholipase 3

  • lysosomal phospholipase A and acyltransferase

  • lysosomal phospholipase A2

Recombinant Pla2g15 Proteins

Cat. No. Product Name Accession Purity
HY-P72293 Group XV phospholipase A2/Pla2g15, Mouse (His, myc) Q8VEB4 (A34-P412) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-18542 KT195 Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10619 PLA2G15 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17862 Pla2g15 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24331 Pla2g15 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pla2g15 NCBI NCBI:23659