PLA2G15 - phospholipase A2 group XV Gene

Also Known as ACS; LLPL; LPLA2; LYPLA3; GXVPLA2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23659

About PLA2G15

Cytogenetic location: 16q22.1 Genomic coordinates (GRCh38): 16:68,245,373-68,261,058 (from NCBI)

This gene has 12 transcripts (splice variants), 213 orthologues and 1 paralogue. Ubiquitous expression in placenta (RPKM 17.1), heart (RPKM 11.8) and 25 other tissues.

Summary

Lysophospholipases are Enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene hydrolyzes lysophosphatidylcholine to glycerophosphorylcholine and a free fatty acid. This enzyme is present in the plasma and thought to be associated with high-density lipoprotein. A later paper contradicts the function of this gene. It demonstrates that this gene encodes a lysosomal enzyme instead of a lysophospholipase and has both calcium-independent Phospholipase A2 and transacylase activities. [provided by RefSeq, Jul 2008]

PLA2G15 Products (2)

mRNA	Protein	Name
NM_001363551.2	NP_001350480.1	phospholipase A2 group XV isoform 2 precursor
NM_012320.4	NP_036452.1	phospholipase A2 group XV isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables O-acyltransferase activity	IDA IDA: Inferred from direct assay	20410020	GOA
enables calcium-independent phospholipase A2 activity	IDA IDA: Inferred from direct assay	29724779	GOA
enables phospholipase A1 activity	IDA IDA: Inferred from direct assay	29724779	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	33961781	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	30830753	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in ceramide metabolic process	IDA IDA: Inferred from direct assay	20410020	GOA
involved in glycerophospholipid metabolic process	IDA IDA: Inferred from direct assay	20410020	GOA
involved in phosphatidylcholine metabolic process	IDA IDA: Inferred from direct assay	29724779	GOA
involved in phosphatidylglycerol metabolic process	IDA IDA: Inferred from direct assay	29724779	GOA
involved in phosphatidylserine metabolic process	IDA IDA: Inferred from direct assay	29724779	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in extracellular space	IDA IDA: Inferred from direct assay	20410020	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PLA2G15 Protein Structure

LCAT

0
100
200
300
412 a.a.

Protein Preferred Names	Protein Names
phospholipase A2 group XV	1-O-acylceramide synthase

PLA2G15 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PLA2G15	Q8NCC3	CCT6A	Homo sapiens	P40227	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

PLA2G15 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P89704	LYPLA3 Antibody (YA9048)	WB, ICC/IF, IF-Tissue, IHC-P, IP, ELISA	human

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-18542	KT195	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10619	PLA2G15 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17862	Pla2g15 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24331	Pla2g15 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PLA2G15	RGD	RGD:1302982
Felis catus	PLA2G15	VGNC	VGNC:64198
Mus musculus	PLA2G15	MGD	MGI:2178076
Bos taurus	PLA2G15	VGNC	VGNC:32956
Macaca mulatta	PLA2G15	VGNC	VGNC:76042
Canis familiaris	PLA2G15	VGNC	VGNC:44621
Others	PLA2G15	NCBI