2. Gene
  3. PLA2G15 - phospholipase A2 group XV Gene

PLA2G15 - phospholipase A2 group XV Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as ACS; LLPL; LPLA2; LYPLA3; GXVPLA2

Gene ID: 23659 | Gene type: protein coding

About PLA2G15

Cytogenetic location: 16q22.1 Genomic coordinates (GRCh38): 16:68,245,373-68,261,058 (from NCBI)

This gene has 12 transcripts (splice variants), 213 orthologues and 1 paralogue. Ubiquitous expression in placenta (RPKM 17.1), heart (RPKM 11.8) and 25 other tissues.

Summary

Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene hydrolyzes lysophosphatidylcholine to glycerophosphorylcholine and a free fatty acid. This Enzyme is present in the plasma and thought to be associated with high-density lipoprotein. A later paper contradicts the function of this gene. It demonstrates that this gene encodes a lysosomal Enzyme instead of a lysophospholipase and has both calcium-independent Phospholipase A2 and transacylase activities. [provided by RefSeq, Jul 2008]

PLA2G15 Products(2)

mRNA Protein Name
NM_001363551.2 NP_001350480.1 phospholipase A2 group XV isoform 2 precursor
NM_012320.4 NP_036452.1 phospholipase A2 group XV isoform 1 precursor

PLA2G15 Protein Structure

LCAT

LCAT: Lecithin:cholesterol acyltransferase (72 - 397)

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  • 412 a.a.
Protein Preferred Names Protein Names

phospholipase A2 group XV

1-O-acylceramide synthase

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10619 PLA2G15 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PLA2G15 RGD RGD:1302982
Felis catus PLA2G15 VGNC VGNC:64198
Mus musculus PLA2G15 MGD MGI:2178076
Bos taurus PLA2G15 VGNC VGNC:32956
Macaca mulatta PLA2G15 VGNC VGNC:76042
Canis familiaris PLA2G15 VGNC VGNC:44621
Others PLA2G15 NCBI