Pts - 6-pyruvoyl-tetrahydropterin synthase Gene
Also Known as PTPS
Species: Mus musculus
Gene Type: protein coding
Gene ID: 19286
Summary
Enables 6-pyruvoyltetrahydropterin synthase activity and identical protein binding activity. Acts upstream of or within tetrahydrobiopterin biosynthetic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Used to study BH4-deficient hyperphenylalaninemia A. Human ortholog(s) of this gene implicated in BH4-deficient hyperphenylalaninemia A and phenylketonuria. Orthologous to human PTS (6-pyruvoyltetrahydropterin synthase). [provided by Alliance of Genome Resources, Apr 2022]
Pts Products (34)
| mRNA | Protein | Name |
|---|---|---|
| NM_001364488.1 | NP_001351417.1 | 6-pyruvoyl tetrahydrobiopterin synthase isoform 2 |
| NM_001364489.1 | NP_001351418.1 | 6-pyruvoyl tetrahydrobiopterin synthase isoform 2 |
| NM_001364490.1 | NP_001351419.1 | 6-pyruvoyl tetrahydrobiopterin synthase isoform 2 |
| NM_001409182.1 | NP_001396111.1 | 6-pyruvoyl tetrahydrobiopterin synthase isoform 2 |
| NM_001409183.1 | NP_001396112.1 | 6-pyruvoyl tetrahydrobiopterin synthase isoform 2 |
| NM_001409184.1 | NP_001396113.1 | 6-pyruvoyl tetrahydrobiopterin synthase isoform 2 |
| NM_001409185.1 | NP_001396114.1 | 6-pyruvoyl tetrahydrobiopterin synthase isoform 2 |
| NM_001409186.1 | NP_001396115.1 | 6-pyruvoyl tetrahydrobiopterin synthase isoform 2 |
| NM_001409187.1 | NP_001396116.1 | 6-pyruvoyl tetrahydrobiopterin synthase isoform 2 |
| NM_001409188.1 | NP_001396117.1 | 6-pyruvoyl tetrahydrobiopterin synthase isoform 2 |
| NM_001409189.1 | NP_001396118.1 | 6-pyruvoyl tetrahydrobiopterin synthase isoform 2 |
| NM_001409190.1 | NP_001396119.1 | 6-pyruvoyl tetrahydrobiopterin synthase isoform 2 |
| NM_001409191.1 | NP_001396120.1 | 6-pyruvoyl tetrahydrobiopterin synthase isoform 2 |
| NM_001409192.1 | NP_001396121.1 | 6-pyruvoyl tetrahydrobiopterin synthase isoform 2 |
| NM_001409193.1 | NP_001396122.1 | 6-pyruvoyl tetrahydrobiopterin synthase isoform 2 |
| NM_001409194.1 | NP_001396123.1 | 6-pyruvoyl tetrahydrobiopterin synthase isoform 2 |
| NM_001409195.1 | NP_001396124.1 | 6-pyruvoyl tetrahydrobiopterin synthase isoform 2 |
| NM_001409196.1 | NP_001396125.1 | 6-pyruvoyl tetrahydrobiopterin synthase isoform 2 |
| NM_001409197.1 | NP_001396126.1 | 6-pyruvoyl tetrahydrobiopterin synthase isoform 2 |
| NM_001409198.1 | NP_001396127.1 | 6-pyruvoyl tetrahydrobiopterin synthase isoform 2 |
| NM_001409199.1 | NP_001396128.1 | 6-pyruvoyl tetrahydrobiopterin synthase isoform 2 |
| NM_001409200.1 | NP_001396129.1 | 6-pyruvoyl tetrahydrobiopterin synthase isoform 2 |
| NM_001409201.1 | NP_001396130.1 | 6-pyruvoyl tetrahydrobiopterin synthase isoform 2 |
| NM_001409202.1 | NP_001396131.1 | 6-pyruvoyl tetrahydrobiopterin synthase isoform 2 |
| NM_001409203.1 | NP_001396132.1 | 6-pyruvoyl tetrahydrobiopterin synthase isoform 3 |
| NM_001409204.1 | NP_001396133.1 | 6-pyruvoyl tetrahydrobiopterin synthase isoform 3 |
| NM_001409205.1 | NP_001396134.1 | 6-pyruvoyl tetrahydrobiopterin synthase isoform 3 |
| NM_001409206.1 | NP_001396135.1 | 6-pyruvoyl tetrahydrobiopterin synthase isoform 3 |
| NM_001409207.1 | NP_001396136.1 | 6-pyruvoyl tetrahydrobiopterin synthase isoform 3 |
| NM_001409209.1 | NP_001396138.1 | 6-pyruvoyl tetrahydrobiopterin synthase isoform 4 |
| NM_001409210.1 | NP_001396139.1 | 6-pyruvoyl tetrahydrobiopterin synthase isoform 5 |
| NM_001409211.1 | NP_001396140.1 | 6-pyruvoyl tetrahydrobiopterin synthase isoform 6 |
| NM_001409214.1 | NP_001396143.1 | 6-pyruvoyl tetrahydrobiopterin synthase isoform 8 |
| NM_011220.3 | NP_035350.1 | 6-pyruvoyl tetrahydrobiopterin synthase isoform 1 |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables 6-pyruvoyltetrahydropterin synthase activity |
IDA
IDA: Inferred from direct assay
|
9894812 | MGI |
| enables identical protein binding |
IPI
IPI: Inferred from physical interaction
|
9894812 | MGI |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| acts upstream of or within tetrahydrobiopterin biosynthetic process |
IDA
IDA: Inferred from direct assay
|
9894812 | MGI |
EXP: Inferred from Experiment
IDA: Inferred from direct assay
IPI: Inferred from physical interaction
IMP: Inferred from mutant phenotype
IGI: Inferred from genetic interaction
IEP: Inferred from expression pattern
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
6-pyruvoyl tetrahydrobiopterin synthase |
|
Related Agents
- Clinical Phase
- Pre-clinical Phase
Clinical Phase
Bioactive Molecules
(1)
| Cat. No. | Product Name |
Effect
|
Purity |
Phase
|
|---|---|---|---|---|
| HY-106031 | F-14512 | Inhibitor | 98.04% | Phase 2 |
Pre-clinical Phase
Bioactive Molecules
(12)
| Cat. No. | Product Name |
Effect
|
Purity |
Rare Diseases
|
|---|---|---|---|---|
| HY-147062 | N-Acetyl-D-galactosamine-6-phosphate | 99.6% | Unkown | |
| HY-N19420 | Theasinensin C | / | Unkown | |
| HY-178872 | Allyl thiosulfate | Inhibitor | 99.92% | Unkown |
| HY-W601362 | N-Acetyl-D-galactosamine-6-phosphate disodium | 98.61% | Unkown | |
| HY-106031A | F-14512 hydrochloride | Inhibitor | / | Unkown |
| HY-143456 | Anti-inflammatory agent 18 | Inhibitor | / | Unkown |
| HY-143457 | Anti-inflammatory agent 19 | Inhibitor | / | Unkown |
| HY-P10230 | Sublancin | Inhibitor | / | Unkown |
| HY-RS11455 | PTS Human Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-116259 | PT-S58 | Antagonist | / | Unkown |
| HY-RS20244 | Pts Mouse Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-RS26752 | Pts Rat Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
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