Hspa1a - heat shock protein 1A Gene

Also Known as Hsp72; hsp68; Hsp70-3; Hsp70.3; hsp70A1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 193740

Summary

Enables protein folding chaperone. Involved in lysosomal transport and protein folding. Acts upstream of or within DNA repair; response to heat; and telomere maintenance. Located in cytoplasm. Is expressed in several structures, including adrenal gland; early conceptus; genitourinary system; and vibrissa. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; autoimmune disease of musculoskeletal system (multiple); cystic fibrosis; schizophrenia (multiple); and toxic shock syndrome. Orthologous to several human genes including HSPA1B (heat shock protein family A (HSP70) member 1B). [provided by Alliance of Genome Resources, Apr 2022]

Hspa1a Products (1)

mRNA Protein Name
NM_010479.2 NP_034609.2 heat shock 70 kDa protein 1A

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
19052621 MGI
enables protein folding chaperone IDA
IDA: Inferred from direct assay
27496612 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within DNA repair IMP
IMP: Inferred from mutant phenotype
14701760 MGI
involved in lysosomal transport IMP
IMP: Inferred from mutant phenotype
27789271 MGI
involved in protein folding IDA
IDA: Inferred from direct assay
27496612 MGI
acts upstream of or within response to heat IDA
IDA: Inferred from direct assay
18755693 MGI
acts upstream of or within response to heat IMP
IMP: Inferred from mutant phenotype
14701760 MGI
acts upstream of or within telomere maintenance IMP
IMP: Inferred from mutant phenotype
14701760 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
16906134 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

heat shock 70 kDa protein 1A

  • 68 kDa heat shock protein

  • heat shock 70 kDa protein 3

  • heat shock 70kDa protein 1A

  • heat shock protein, 70 kDa 3

  • inducible heat shock protein 70

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-162567 AP-4-139B 98.87% Unkown
HY-RS06424 HSPA1A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18094 Hspa1a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-117252 HS-72 Inhibitor / Unkown
HY-RS24569 Hspa1a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hspa1a NCBI NCBI:3303