Kdm4b - lysine (K)-specific demethylase 4B Gene

Also Known as Jmjd2b; 4732474L06Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 193796

Summary

Enables histone H3-methyl-lysine-9 demethylase activity. Acts upstream of or within histone H3-K36 demethylation; histone H3-K9 demethylation; and negative regulation of histone H3-K9 trimethylation. Located in pericentric heterochromatin. Is expressed in several structures, including early conceptus; genitourinary system; heart; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability; breast cancer; colorectal cancer; malignant peripheral nerve sheath tumor; and stomach Cancer. Orthologous to human KDM4B (lysine demethylase 4B). [provided by Alliance of Genome Resources, Apr 2022]

Kdm4b Products (2)

mRNA Protein Name
NM_001357909.1 NP_001344838.1 lysine-specific demethylase 4B isoform 2
NM_172132.3 NP_742144.1 lysine-specific demethylase 4B isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables histone H3K36 demethylase activity IDA
IDA: Inferred from direct assay
16738407 MGI
enables histone H3K36 demethylase activity IMP
IMP: Inferred from mutant phenotype
16738407 MGI
enables histone H3K9 demethylase activity IDA
IDA: Inferred from direct assay
16738407 MGI
enables histone H3K9 demethylase activity IMP
IMP: Inferred from mutant phenotype
16738407 MGI
enables histone demethylase activity IDA
IDA: Inferred from direct assay
19144645 MGI
Biological Process GO Annotation Evidence Références Source
involved in brain development IMP
IMP: Inferred from mutant phenotype
27023172 MGI
Cellular Component GO Annotation Evidence Références Source
located in pericentric heterochromatin IDA
IDA: Inferred from direct assay
16738407 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

lysine-specific demethylase 4B

  • [histone H3]-trimethyl-L-lysine(9) demethylase 4B

  • jmjC domain-containing histone demethylation protein 3B

  • jumonji domain-containing protein 2B

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-104048 QC6352 Inhibitor 99.13% Unkown
HY-12725 ML324 Inhibitor 98.35% Unkown
HY-148807 Zavondemstat 99.29% Unkown
HY-101799 NCGC00244536 Inhibitor 99.70% Unkown
HY-110154 NSC636819 98.90% Unkown
HY-RS07214 KDM4B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-173135 PROTAC KDM4 degrader-1 / Unkown
HY-RS17132 Kdm4b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23577 Kdm4b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Kdm4b NCBI NCBI:23030