Rarg - retinoic acid receptor, gamma Gene

Also Known as RARD; Nr1b3; RAR-gamma; RARgamma2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 19411

Summary

Enables several functions, including DNA-binding transcription factor activity; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and retinoid X receptor binding activity. Involved in growth plate cartilage chondrocyte growth and limb development. Acts upstream of or within several processes, including animal organ development; regulation of apoptotic process; and regulation of transcription by RNA polymerase II. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and limb. Orthologous to human RARG (retinoic acid receptor gamma). [provided by Alliance of Genome Resources, Apr 2022]

Rarg Products (3)

mRNA Protein Name
NM_001042727.3 NP_001036192.1 retinoic acid receptor gamma isoform 2
NM_001411714.1 NP_001398643.1 retinoic acid receptor gamma isoform 1
NM_011244.5 NP_035374.3 retinoic acid receptor gamma isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
18439490 MGI
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
18439490 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
15327771 MGI
enables nuclear retinoid X receptor binding IMP
IMP: Inferred from mutant phenotype
18439490 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
15327771 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within Harderian gland development IMP
IMP: Inferred from mutant phenotype
8388780 MGI
acts upstream of or within anterior/posterior pattern specification IGI
IGI: Inferred from genetic interaction
11784046 MGI
acts upstream of or within anterior/posterior pattern specification IMP
IMP: Inferred from mutant phenotype
8388780 MGI
acts upstream of apoptotic process IGI
IGI: Inferred from genetic interaction
16207763 MGI
acts upstream of or within bone development IGI
IGI: Inferred from genetic interaction
7607067 MGI
involved in bone development IMP
IMP: Inferred from mutant phenotype
19389355 MGI
acts upstream of or within bone morphogenesis IGI
IGI: Inferred from genetic interaction
11784046 MGI
acts upstream of or within bone morphogenesis IMP
IMP: Inferred from mutant phenotype
8388780 MGI
acts upstream of cell population proliferation IGI
IGI: Inferred from genetic interaction
10075839 MGI
acts upstream of or within cellular response to leukemia inhibitory factor IEP
IEP: Inferred from expression pattern
20439489 MGI
involved in chondrocyte development IMP
IMP: Inferred from mutant phenotype
19389355 MGI
acts upstream of or within embryonic camera-type eye development IGI
IGI: Inferred from genetic interaction
7607067 MGI
acts upstream of or within embryonic eye morphogenesis IGI
IGI: Inferred from genetic interaction
16207763 MGI
acts upstream of or within embryonic hindlimb morphogenesis IGI
IGI: Inferred from genetic interaction
10075839 MGI
acts upstream of or within epithelium development IMP
IMP: Inferred from mutant phenotype
8388780 MGI
acts upstream of or within face development IGI
IGI: Inferred from genetic interaction
7607067 MGI
acts upstream of or within gland development IMP
IMP: Inferred from mutant phenotype
8388780 MGI
acts upstream of or within glandular epithelial cell development IGI
IGI: Inferred from genetic interaction
7607067 MGI
involved in growth plate cartilage chondrocyte growth IMP
IMP: Inferred from mutant phenotype
19389355 MGI
acts upstream of or within growth plate cartilage development IGI
IGI: Inferred from genetic interaction
19389355 MGI
acts upstream of or within limb development IGI
IGI: Inferred from genetic interaction
7607067 MGI
involved in limb development IMP
IMP: Inferred from mutant phenotype
19389355 MGI
acts upstream of or within multicellular organism growth IGI
IGI: Inferred from genetic interaction
19389355 MGI
acts upstream of or within negative regulation of cartilage development IMP
IMP: Inferred from mutant phenotype
10684250 MGI
acts upstream of or within negative regulation of cell differentiation IMP
IMP: Inferred from mutant phenotype
10684250 MGI
acts upstream of or within negative regulation of chondrocyte differentiation IMP
IMP: Inferred from mutant phenotype
10684250 MGI
acts upstream of or within negative regulation of stem cell proliferation IGI
IGI: Inferred from genetic interaction
10075839 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
8152920 MGI
acts upstream of or within neural tube closure IGI
IGI: Inferred from genetic interaction
7607067 MGI
acts upstream of or within positive regulation of apoptotic process IGI
IGI: Inferred from genetic interaction
16207763 MGI
acts upstream of or within positive regulation of gene expression IDA
IDA: Inferred from direct assay
19389355 MGI
acts upstream of or within positive regulation of programmed cell death IGI
IGI: Inferred from genetic interaction
10075839 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
15327771 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
15766748 MGI
acts upstream of programmed cell death IGI
IGI: Inferred from genetic interaction
10075839 MGI
acts upstream of or within prostate gland epithelium morphogenesis IMP
IMP: Inferred from mutant phenotype
8388780 MGI
acts upstream of or within regulation of gene expression IGI
IGI: Inferred from genetic interaction
19389355 MGI
acts upstream of or within regulation of myeloid cell differentiation IGI
IGI: Inferred from genetic interaction
23136256 MGI
acts upstream of or within reproductive structure development IMP
IMP: Inferred from mutant phenotype
8388780 MGI
acts upstream of or within retinoic acid receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
8388780 MGI
acts upstream of stem cell proliferation IGI
IGI: Inferred from genetic interaction
10075839 MGI
acts upstream of or within trachea cartilage development IMP
IMP: Inferred from mutant phenotype
8388780 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
15327771 MGI
part of transcription regulator complex IDA
IDA: Inferred from direct assay
18439490 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

retinoic acid receptor gamma

  • RAR gamma 2

  • nuclear receptor subfamily 1 group B member 3

  • retinoic acid receptor gamma 4

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-155108 OATD-02 Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-155108B OATD-02 hydrochloride Inhibitor 99.88% Unkown
HY-RS11673 RARG Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22294 Rarg Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28817 Rarg Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rarg NCBI NCBI:5916