RARG - retinoic acid receptor gamma Gene

Also Known as RARC; NR1B3; RARgamma

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5916

About RARG

Cytogenetic location: 12q13.13 Genomic coordinates (GRCh38): 12:53,210,569-53,232,209 (from NCBI)

This gene has 18 transcripts (splice variants), 449 orthologues and 18 paralogues. Broad expression in skin (RPKM 47.1), esophagus (RPKM 32.0) and 18 other tissues.

Summary

This gene encodes a retinoic acid receptor that belongs to the nuclear hormone receptor family. Retinoic acid receptors (RARs) act as ligand-dependent transcriptional regulators. When bound to ligands, RARs activate transcription by binding as heterodimers to the retinoic acid response elements (RARE) found in the promoter regions of the target genes. In their unbound form, RARs repress transcription of their target genes. RARs are involved in various biological processes, including limb bud development, skeletal growth, and matrix homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

RARG Products (5)

mRNA Protein Name
NM_000966.6 NP_000957.1 retinoic acid receptor gamma isoform 1
NM_001042728.3 NP_001036193.1 retinoic acid receptor gamma isoform 2
NM_001243730.2 NP_001230659.1 retinoic acid receptor gamma isoform 4
NM_001243731.2 NP_001230660.1 retinoic acid receptor gamma isoform 5
NM_001243732.2 NP_001230661.1 retinoic acid receptor gamma isoform 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
10428834 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
Biological Process GO Annotation Evidence References Source
involved in response to retinoic acid IDA
IDA: Inferred from direct assay
17943189 GOA
involved in retinoic acid receptor signaling pathway IDA
IDA: Inferred from direct assay
17943189 GOA
Cellular Component GO Annotation Evidence References Source
located in chromatin IDA
IDA: Inferred from direct assay
21131358 GOA
located in nucleus IDA
IDA: Inferred from direct assay
18845237 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RARG Protein Structure

zf-C4

zf-C4: Zinc finger, C4 type (two domains) (89 - 157)

Hormone_recep

Hormone_recep: Ligand-binding domain of nuclear hormone receptor (227 - 395)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 454 a.a.
Protein Preferred Names Protein Names

retinoic acid receptor gamma

  • RAR-gamma

RARG Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RARG P13631 SORBS3 Homo sapiens O60504-2
Anti Bait CoIP
15734736
Intra
RARG P13631 MYF5 Homo sapiens P13349
Y2H Array
32296183
Intra
RARG P13631 MYF5 Homo sapiens P13349
Y2H Prey Pooling
32296183
Intra
RARG P13631 BBS4 Homo sapiens Q96RK4
Y2H Prey Pooling
32296183
Intra
RARG P13631 BBS4 Homo sapiens Q96RK4
Validated Y2H
32296183
Intra
RARG P13631 BBS4 Homo sapiens Q96RK4
Y2H Array
32296183
Intra
RARG P13631 PRKAR1B Homo sapiens P31321
Y2H Array
32296183
Intra
RARG P13631 PRKAR1B Homo sapiens P31321
Validated Y2H
32296183
Intra
RARG P13631 PRKAR1B Homo sapiens P31321
Y2H Prey Pooling
32296183
Intra
RARG P13631 RXRG Homo sapiens P48443
Validated Y2H
32296183
Intra
RARG P13631 RXRB Homo sapiens P28702
Anti Tag CoIP
33961781
Intra
RARG P13631 RXRB Homo sapiens P28702
Anti Tag CoIP
28514442
Intra
RARG P13631 RXRB Homo sapiens P28702
Validated Y2H
32296183
Intra
RARG P13631 RXRB Homo sapiens P28702
Y2H Prey Pooling
32296183
Intra
RARG P13631 RXRB Homo sapiens P28702
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

RARG Antibodies

Cat. No. Product Name Application Reactivity
HY-P82115 Retinoic Acid Receptor gamma Antibody (YA1860) WB, ICC/IF Human, Rat

Related Diseases

Diseases Alias
Embryonal Carcinoma

  • Embryonal Neoplasm

  • Embryonal Cancer

  • Primary Extragonadal Embryonal Carcinoma

  • Embryo Neoplasm

  • Carcinoma Embryonal

  • Cancer Embryonal

  • Carcinoma, Embryonal

  • Extragonadal Embryonal Carcinoma

  • Cancer, Embryonal
Acute Promyelocytic Leukemia

  • Leukemia, Acute Promyelocytic

  • Acute Myeloblastic Leukemia Type 3

  • Aml M3

  • APL

  • Leukemia, Acute Promyelocytic, Somatic

  • Aml With T(15

  • 17)(Q22

  • Q12)

  • (Pml/Raralpha) And Variants

  • Apml

  • Acute Myeloblastic Leukemia 3

  • Acute Myeloid Leukemia With T(15

  • 17)(Q22

  • Q12)

  • (Pml/Raralpha) And Variants

  • Acute Myeloblastic Leukaemia Type 3

  • Acute Myeloid Leukaemia M3

  • Acute Myeloid Leukemia M3

  • Acute Promyelocytic Leukaemia

  • M3 Anll

  • Myeloid Leukemia, Acute, M3

  • Leukemia Promyelocytic Acute

  • Leukemia, Promyelocytic, Acute

  • Leukemia, Acute, Promyelocytic
Fibrodysplasia Ossificans Progressiva

  • Myositis Ossificans Progressiva

  • Progressive Myositis Ossificans

  • FOP

  • Progressive Ossifying Myositis

  • Myositis Ossificans

  • Stone Man Syndrome

  • Man Of Stone

  • Myositis Ossificans Progressive

  • Diffuse Progressive Ossifying Polymyositis

  • Fibrodysplasia Ossificans Congenita

  • Myositis Ossificans Progressiva, Site Unspecified

  • Münchmeyer Disease

  • Fop - [Fibrodysplasia Ossificans Progressiva]

  • Progressive Myositis Ossificans Calcification
Pancreatic Cancer

  • Pancreatic Carcinoma

  • Carcinoma Of Pancreas

  • Familial Pancreatic Carcinoma

  • Pancreatic Neoplasm

  • Pancreatic Carcinoma, Familial

  • Malignant Neoplasm Of Pancreas

  • Pancreatic Acinar Carcinoma

  • Pancreatic Tumor

  • Familial Pancreatic Cancer

  • Neoplasm Of The Pancreas

  • Cancer Of The Pancreas

  • Pancreatic Carcinoma, Somatic

  • Pancreatic Cancer, Somatic

  • Ca Body Of Pancreas

  • Ca Head Of Pancreas

  • Ca Tail Of Pancreas

  • Malignant Neoplasm Of Body Of Pancreas

  • Malignant Neoplasm Of Head Of Pancreas

  • Malignant Neoplasm Of Tail Of Pancreas

  • Pancreas Neoplasm

  • Exocrine Cancer

  • Exocrine Pancreas Carcinoma

  • Hereditary Pancreatic Cancer

  • Hereditary Pancreatic Carcinoma

  • PNCA

  • Pancreatic Cancer, Susceptibility To

  • Carcinoma Of Head Of Pancreas

  • Pancreatic Neoplasms

  • Pancreatic Tumors

  • Cancer, Pancreatic

  • Cancer Of Pancreas

  • Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-155108B OATD-02 hydrochloride Inhibitor 99.88% Phase 1
HY-155108 OATD-02 Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11673 RARG Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22294 Rarg Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28817 Rarg Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus RARG VGNC VGNC:33730
Felis catus RARG VGNC VGNC:69242
Canis familiaris RARG VGNC VGNC:45353
Macaca mulatta RARG VGNC VGNC:76664
Rattus norvegicus RARG RGD RGD:1583230
Mus musculus RARG MGD MGI:97858
Others RARG NCBI