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Nlrp1a - NLR family, pyrin domain containing 1A Gene

Also Known as NAC; Gm14; Gm15; CARD7; Nalp1; Nlrp1; DEFCAP; Nalp1a; PP1044

Species: Mus musculus

Gene Type: protein coding

Gene ID: 195046

About Nlrp1a

Chromosome 11: 70,983,062-71,035,530 reverse strand.GRCm39:CM001004.3

This gene has 2 transcripts (splice variants), 88 orthologues, 22 paralogues and is associated with 37 phenotypes. Low expression observed in reference dataset.

Summary

Predicted to enable several functions, including ATP binding activity; cysteine-type endopeptidase activator activity; and nucleic acid binding activity. Involved in positive regulation of interleukin-1 beta production and response to muramyl dipeptide. Acts upstream of or within defense response to bacterium and programmed necrotic cell death. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of NLRP1 inflammasome complex. Human ortholog(s) of this gene implicated in vitiligo. Orthologous to human NLRP1 (NLR family pyrin domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]

Nlrp1a Products (1)

mRNA	Protein	Name
NM_001004142.2	NP_001004142.2	NACHT, LRR and PYD domains-containing protein 1a

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	18511561	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within defense response to bacterium	IDA IDA: Inferred from direct assay	16429160	MGI
involved in positive regulation of interleukin-1 beta production	IDA IDA: Inferred from direct assay	18511561	MGI
acts upstream of or within programmed necrotic cell death	IDA IDA: Inferred from direct assay	16429160	MGI
involved in response to muramyl dipeptide	IDA IDA: Inferred from direct assay	18511561	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Nlrp1a Protein Structure

NACHT

NOD2_WH

NLRC4_HD2

PPP1R42

LRR_1

LRR_RI

FIIND

CARD_ASC_NALP1

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1182 a.a.

Protein Preferred Names	Protein Names
NACHT, LRR and PYD domains-containing protein 1a	NACHT, LRR and PYD containing protein 1 NACHT, leucine rich repeat and PYD containing 1 NACHT/LRR/pyrin domain-containing protein 1 NLR family, pyrin domain containing 1 NLR family, pyrin domain containing 1A, CAST/EiJ strain specific NLR family, pyrin domain containing 1A, PWK/PhJ strain specific NLR family, pyrin domain containing 1A, WSB/EiJ strain specific caspase recruitment domain protein caspase recruitment domain-containing protein 7 death effector filament-forming Ced-4-like apoptosis p

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09354	Nlrp1a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS09355	Nlrp1a Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown