2. Gene
  3. Nlrp1a - NLR family, pyrin domain containing 1A Gene

Nlrp1a - NLR family, pyrin domain containing 1A Gene

  • Gene
  • Protein
  • Agent
Mus musculus

Also known as NAC; Gm14; Gm15; CARD7; Nalp1; Nlrp1; DEFCAP; Nalp1a; PP1044

Gene ID: 195046 | Gene type: protein coding

About Nlrp1a

Chromosome 11: 70,983,062-71,035,530 reverse strand.GRCm39:CM001004.3

This gene has 2 transcripts (splice variants), 88 orthologues, 22 paralogues and is associated with 37 phenotypes. Low expression observed in reference dataset.

Summary

Predicted to enable several functions, including ATP binding activity; cysteine-type endopeptidase activator activity; and nucleic acid binding activity. Involved in positive regulation of interleukin-1 beta production and response to muramyl dipeptide. Acts upstream of or within defense response to bacterium and programmed necrotic cell death. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of NLRP1 inflammasome complex. Human ortholog(s) of this gene implicated in vitiligo. Orthologous to human NLRP1 (NLR family pyrin domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]

Nlrp1a Products(1)

mRNA Protein Name
NM_001004142.2 NP_001004142.2 NACHT, LRR and PYD domains-containing protein 1a

Nlrp1a Protein Structure

NACHT

NACHT: pfam05729 (132 - 298)

NOD2_WH

NOD2_WH: pfam17779 (371 - 425)

NLRC4_HD2

NLRC4_HD2: pfam17776 (427 - 539)

PPP1R42

PPP1R42: cl42388 (616 - 726)

LRR_1

LRR_1: sd00031 (634 - 662)

LRR_1

LRR_1: sd00031 (663 - 690)

LRR_RI

LRR_RI: sd00033 (720 - 741)

FIIND

FIIND: pfam13553 (819 - 1071)

CARD_ASC_NALP1

CARD_ASC_NALP1: cd08330 (1091 - 1171)

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  • 1182 a.a.
Protein Preferred Names Protein Names

NACHT, LRR and PYD domains-containing protein 1a

NACHT, LRR and PYD containing protein 1

NACHT, leucine rich repeat and PYD containing 1

NACHT/LRR/pyrin domain-containing protein 1

NLR family, pyrin domain containing 1

NLR family, pyrin domain containing 1A, CAST/EiJ strain specific

NLR family, pyrin domain containing 1A, PWK/PhJ strain specific

NLR family, pyrin domain containing 1A, WSB/EiJ strain specific

caspase recruitment domain protein

caspase recruitment domain-containing protein 7

death effector filament-forming Ced-4-like apoptosis p

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09354 Nlrp1a Mouse Pre-designed siRNA Set A / Unkown
HY-RS09355 Nlrp1a Rat Pre-designed siRNA Set A / Unkown