Rbm4 - RNA binding motif protein 4 Gene

Also Known as lark; Lark1; Mlark; Rbm4a; 4921506I22Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 19653

Summary

Enables mRNA 3'-UTR binding activity and pre-mRNA binding activity. Involved in circadian regulation of translation; entrainment of circadian clock by photoperiod; and regulation of nucleocytoplasmic transport. Acts upstream of or within several processes, including Insulin secretion involved in cellular response to glucose stimulus; regulation of gene expression; and regulation of Insulin Receptor signaling pathway. Located in nucleolus and perinuclear region of cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human RBM4 (RNA binding motif protein 4). [provided by Alliance of Genome Resources, Apr 2022]

Rbm4 Products (5)

mRNA	Protein	Name
NM_001290122.1	NP_001277051.1	RNA-binding protein 4 isoform a
NM_001290123.1	NP_001277052.1	RNA-binding protein 4 isoform a
NM_001290124.1	NP_001277053.1	RNA-binding protein 4 isoform b
NM_001290125.1	NP_001277054.1	RNA-binding protein 4 isoform b
NM_009032.3	NP_033058.2	RNA-binding protein 4 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables mRNA 3'-UTR binding	IDA IDA: Inferred from direct assay	17264215	MGI
enables pre-mRNA binding	IDA IDA: Inferred from direct assay	16260624	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within circadian regulation of gene expression	IMP IMP: Inferred from mutant phenotype	17264215	MGI
involved in circadian regulation of translation	IDA IDA: Inferred from direct assay	17264215	MGI
acts upstream of or within enteroendocrine cell differentiation	IMP IMP: Inferred from mutant phenotype	23129807	MGI
involved in entrainment of circadian clock by photoperiod	IDA IDA: Inferred from direct assay	17264215	MGI
acts upstream of or within glucose homeostasis	IMP IMP: Inferred from mutant phenotype	23129807	MGI
acts upstream of or within insulin secretion involved in cellular response to glucose stimulus	IMP IMP: Inferred from mutant phenotype	23129807	MGI
acts upstream of or within pancreas development	IMP IMP: Inferred from mutant phenotype	23129807	MGI
acts upstream of or within positive regulation of translation	IDA IDA: Inferred from direct assay	17264215	MGI
acts upstream of or within regulation of alternative mRNA splicing, via spliceosome	IMP IMP: Inferred from mutant phenotype	23129807	MGI
acts upstream of or within regulation of gene expression	IMP IMP: Inferred from mutant phenotype	23129807	MGI
acts upstream of or within regulation of insulin receptor signaling pathway	IDA IDA: Inferred from direct assay	23129807	MGI
involved in regulation of nucleocytoplasmic transport	IDA IDA: Inferred from direct assay	19801630	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	19801630	MGI
located in nucleolus	IDA IDA: Inferred from direct assay	19801630	MGI
located in nucleus	IDA IDA: Inferred from direct assay	19801630	MGI
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	19801630	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
RNA-binding protein 4	RNA-binding motif protein 4a lark homolog

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11752	RBM4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19942	Rbm4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26444	Rbm4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Rbm4	NCBI	NCBI:5936