Rfx3 - regulatory factor X, 3 (influences HLA class II expression) Gene

Also Known as MRFX3; C230093O12Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 19726

Summary

Enables DNA-binding transcription factor activity and transcription cis-regulatory region binding activity. Involved in several processes, including epithelial cilium movement involved in determination of left/right asymmetry; positive regulation of type B pancreatic cell development; and type B pancreatic cell maturation. Acts upstream of or within determination of left/right symmetry. Located in chromatin. Part of transcription regulator complex. Is expressed in several structures, including central nervous system; genitourinary system; inner cell mass; pancreas; and sensory organ. Used to study visceral heterotaxy. Orthologous to human RFX3 (regulatory factor X3). [provided by Alliance of Genome Resources, Apr 2022]

Rfx3 Products (4)

mRNA	Protein	Name
NM_001166414.2	NP_001159886.1	transcription factor RFX3 isoform 1
NM_001360357.1	NP_001347286.1	transcription factor RFX3 isoform 2
NM_001360358.1	NP_001347287.1	transcription factor RFX3 isoform 3
NM_011265.3	NP_035395.2	transcription factor RFX3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	20413507	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	20148032	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	24531968	MGI
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	19671664	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	19671664	MGI
involved in cell maturation	IMP IMP: Inferred from mutant phenotype	20413507	MGI
involved in cilium assembly	IMP IMP: Inferred from mutant phenotype	20413507	MGI
involved in cilium-dependent cell motility	IMP IMP: Inferred from mutant phenotype	19671664	MGI
acts upstream of or within determination of left/right symmetry	IMP IMP: Inferred from mutant phenotype	15121860	MGI
involved in endocrine pancreas development	IMP IMP: Inferred from mutant phenotype	17229940	MGI
involved in epithelial cilium movement involved in determination of left/right asymmetry	IMP IMP: Inferred from mutant phenotype	15121860	MGI
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	20413507	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	20413507	MGI
involved in positive regulation of type B pancreatic cell development	IMP IMP: Inferred from mutant phenotype	20413507	MGI
involved in regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	15121860	MGI
involved in regulation of insulin secretion	IMP IMP: Inferred from mutant phenotype	17229940	MGI
involved in type B pancreatic cell maturation	IMP IMP: Inferred from mutant phenotype	20413507	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in chromatin	IDA IDA: Inferred from direct assay	20413507	MGI
part of transcription regulator complex	IDA IDA: Inferred from direct assay	20413507	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
transcription factor RFX3	regulatory factor X 3

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11881	RFX3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22300	Rfx3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28823	Rfx3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Rfx3	NCBI	NCBI:5991