Mst1r - macrophage stimulating 1 receptor (c-met-related tyrosine kinase) Gene

Also Known as Fv2; Ron; STK; Fv-2; PTK8; CD136; CDw136; p185-Ron

Species: Mus musculus

Gene Type: protein coding
Gene ID: 19882

Summary

This gene encodes a precursor protein that is proteolytically cleaved to yield an alpha chain and a beta chain which form a membrane-spanning heterodimer. The encoded protein belongs to a family of cell-surface Receptor Tyrosine Kinases involved in signaling from the cell surface to the intracellular environment. The binding of the encoded protein to its ligand, macrophage-stimulating protein, mediates several biological activities including wound healing, tumor immunity, macrophage activation and hematopoiesis as well as cell growth, motility, survival and adhesion. The protein encoded by this gene also functions in early development and the macrophage-mediated inflammatory response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

Mst1r Products (3)

mRNA Protein Name
NM_001287261.2 NP_001274190.1 macrophage-stimulating protein receptor isoform 2
NM_001413562.1 NP_001400491.1 macrophage-stimulating protein receptor isoform 3 precursor
NM_009074.3 NP_033100.2 macrophage-stimulating protein receptor isoform 1 preproprotein

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within response to virus IMP
IMP: Inferred from mutant phenotype
10508511 MGI
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
12606483 MGI
located in stress fiber IDA
IDA: Inferred from direct assay
12606483 MGI
located in vacuole IDA
IDA: Inferred from direct assay
25049204 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

macrophage-stimulating protein receptor

  • MSP receptor

  • friend virus susceptibility 2

  • receptor protein tyrosine kinase, c-met-related

  • stem cell-derived tyrosine kinase

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-15514 Merestinib Inhibitor 99.99% Phase 2
HY-15514A Merestinib dihydrochloride Inhibitor 99.36% Phase 2

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08730 MST1R Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18291 Mst1r Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24769 Mst1r Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Bioactive MoleculesInhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991185 Anti-MST1R Antibody (MOR07692) Inhibitor 99.44% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mst1r NCBI NCBI:4486