Rrm1 - ribonucleotide reductase M1 Gene

Also Known as RnrM1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20133

Summary

Enables disordered domain specific binding activity and purine nucleotide binding activity. Contributes to ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor. Involved in deoxyribonucleotide biosynthetic process and protein heterotetramerization. Part of ribonucleoside-diphosphate reductase complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Orthologous to human RRM1 (ribonucleotide reductase catalytic subunit M1). [provided by Alliance of Genome Resources, Apr 2022]

Rrm1 Products (1)

mRNA Protein Name
NM_009103.3 NP_033129.2 ribonucleoside-diphosphate reductase large subunit

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables disordered domain specific binding IPI
IPI: Inferred from physical interaction
8130196 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
16829694 MGI
enables purine nucleotide binding IDA
IDA: Inferred from direct assay
16861739 MGI
contributes to ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor IDA
IDA: Inferred from direct assay
16861739 MGI
enables ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor IDA
IDA: Inferred from direct assay
19176520 MGI
Biological Process GO Annotation Evidence References Source
involved in 2'-deoxyribonucleotide biosynthetic process IDA
IDA: Inferred from direct assay
12578384 MGI
involved in deoxyribonucleotide biosynthetic process IDA
IDA: Inferred from direct assay
19176520 MGI
involved in mitochondrial DNA replication IMP
IMP: Inferred from mutant phenotype
17486094 MGI
involved in positive regulation of G0 to G1 transition IDA
IDA: Inferred from direct assay
11517226 MGI
involved in protein heterotetramerization IPI
IPI: Inferred from physical interaction
19176520 MGI
involved in ribonucleoside diphosphate metabolic process IDA
IDA: Inferred from direct assay
12578384 MGI
Cellular Component GO Annotation Evidence References Source
part of ribonucleoside-diphosphate reductase complex IDA
IDA: Inferred from direct assay
19176520 MGI
part of ribonucleoside-diphosphate reductase complex IMP
IMP: Inferred from mutant phenotype
8130196 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ribonucleoside-diphosphate reductase large subunit

  • ribonucleoside-diphosphate reductase subunit M1

  • ribonucleotide reductase large subunit

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N0527 Pentagalloylglucose 99.57% Unkown
HY-P5960 PTBP1-RNA-binding inhibitor P6 TFA 98.59% Unkown
HY-153898 rTRD01 Ligand 99.10% Unkown
HY-153736 NSC 194308 99.86% Unkown
HY-RS12285 RRM1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18637 Rrm1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25122 Rrm1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rrm1 NCBI NCBI:6240