Rrm2 - ribonucleotide reductase M2 Gene

Also Known as R2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20135

Summary

Enables ferric iron binding activity and protein homodimerization activity. Contributes to ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor. Involved in deoxyribonucleotide biosynthetic process and protein heterotetramerization. Acts upstream of or within deoxyribonucleotide metabolic process. Part of ribonucleoside-diphosphate reductase complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb; and sensory organ. Human ortholog(s) of this gene implicated in pancreatic Cancer. Orthologous to human RRM2 (ribonucleotide reductase regulatory subunit M2). [provided by Alliance of Genome Resources, Apr 2022]

Rrm2 Products (1)

mRNA Protein Name
NM_009104.2 NP_033130.1 ribonucleoside-diphosphate reductase subunit M2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ferric iron binding IDA
IDA: Inferred from direct assay
8876648 MGI
enables identical protein binding IMP
IMP: Inferred from mutant phenotype
8130196 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
8130196 MGI
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
8876648 MGI
contributes to ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor IDA
IDA: Inferred from direct assay
8612737 MGI
enables ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor IDA
IDA: Inferred from direct assay
16829694 MGI
contributes to ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor IMP
IMP: Inferred from mutant phenotype
2684652 MGI
Biological Process GO Annotation Evidence References Source
involved in 2'-deoxyribonucleotide biosynthetic process IDA
IDA: Inferred from direct assay
12578384 MGI
acts upstream of blastocyst development IMP
IMP: Inferred from mutant phenotype
26902285 MGI
involved in deoxyribonucleotide biosynthetic process IDA
IDA: Inferred from direct assay
19176520 MGI
acts upstream of or within deoxyribonucleotide metabolic process IDA
IDA: Inferred from direct assay
12655059 MGI
involved in protein heterotetramerization IPI
IPI: Inferred from physical interaction
19176520 MGI
involved in ribonucleoside diphosphate metabolic process IDA
IDA: Inferred from direct assay
12578384 MGI
Cellular Component GO Annotation Evidence References Source
part of ribonucleoside-diphosphate reductase complex IDA
IDA: Inferred from direct assay
8876648 MGI
part of ribonucleoside-diphosphate reductase complex IMP
IMP: Inferred from mutant phenotype
8130196 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ribonucleoside-diphosphate reductase subunit M2

  • ribonucleoside-diphosphate reductase M2 chain

  • ribonucleotide reductase small chain

  • ribonucleotide reductase small subunit

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-30272 Monobenzone 99.93% Unkown
HY-B2116 Osalmid Inhibitor 99.91% Unkown

Pre-clinical Phase

Bioactive Molecules (11)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N0527 Pentagalloylglucose 99.57% Unkown
HY-P5960 PTBP1-RNA-binding inhibitor P6 TFA 98.59% Unkown
HY-153898 rTRD01 Ligand 99.10% Unkown
HY-153736 NSC 194308 99.86% Unkown
HY-112358 GW8510 Inhibitor 99.04% Unkown
HY-RS12286 RRM2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12287 RRM2B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16616 Rrm2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21746 Rrm2b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23051 Rrm2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28263 Rrm2b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rrm2 NCBI NCBI:6241