RAB12 - RAB12, member RAS oncogene family Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 201475

About RAB12

Cytogenetic location: 18p11.22 Genomic coordinates (GRCh38): 18:8,609,437-8,639,383 (from NCBI)

This gene has 2 transcripts (splice variants), 201 orthologues and 68 paralogues. Ubiquitous expression in heart (RPKM 8.8), fat (RPKM 6.8) and 25 other tissues.

Summary

Enables GDP binding activity. Predicted to be involved in several processes, including cellular response to Insulin stimulus; endosome to lysosome transport; and secretion by cell. Predicted to act upstream of or within cellular response to interferon-gamma. Predicted to be located in lysosome; phagocytic vesicle; and recycling endosome membrane. Predicted to be active in Golgi apparatus; cytoplasmic vesicle; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

RAB12 Products (1)

mRNA Protein Name
NM_001025300.3 NP_001020471.3 ras-related protein Rab-12

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables GDP binding IDA
IDA: Inferred from direct assay
20937701 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
26824392 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RAB12 Protein Structure

Ras

Ras: Ras family (45 - 205)

  • 0
  • 100
  • 200
  • 244 a.a.
Protein Preferred Names Protein Names

ras-related protein Rab-12

  • putative Ras-related protein Rab-12

RAB12 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RAB12 Q6IQ22 LRRK2 Homo sapiens Q5S007
Anti Tag CoIP
26824392
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Newfoundland Rod-Cone Dystrophy

  • Newfoundland Cone-Rod Dystrophy

  • NFRCD

  • Rod-Cone Dystrophy Newfoundland
Periampullary Adenocarcinoma
Parkinson Disease, Late-Onset

  • Parkinson Disease

  • Parkinson'S Disease

  • PD

  • PARK

  • Parkinson Disease, Susceptibility To

  • Late Onset Parkinson'S Disease

  • Late Onset Parkinson Disease

  • Paralysis Agitans

  • Primary Parkinsonism

  • Idiopathic Parkinson Disease

  • Parkinson'S

  • Parkinson Disease, Late-Onset, Susceptibility To

  • Parkinson Disease, Age Of Onset, Modifier

  • Lewy Body Parkinson Disease

  • Idiopathic Parkinson'S Disease

  • Pd - [Parkinson Disease]

  • Parkinson Disease Nos

  • Parkinson, Nos

  • Primary Parkinson Disease
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11521 RAB12 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-180320 Lu AF58786 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus RAB12 MGD MGI:894284
Rattus norvegicus RAB12 RGD RGD:3527
Felis catus RAB12 VGNC VGNC:80472
Bos taurus RAB12 VGNC VGNC:33620
Macaca mulatta RAB12 VGNC VGNC:104237
Canis familiaris RAB12 VGNC VGNC:103700
Others RAB12 NCBI