2. Gene
  3. ADGRE1 - adhesion G protein-coupled receptor E1 Gene

ADGRE1 - adhesion G protein-coupled receptor E1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as EMR1; TM7LN3

Gene ID: 2015 | Gene type: protein coding

About ADGRE1

Cytogenetic location: 19p13.3-p13.2 Genomic coordinates (GRCh38): 19:6,887,579-6,940,450 (from NCBI)

This gene has 8 transcripts (splice variants), 103 orthologues and 42 paralogues. Biased expression in spleen (RPKM 6.8), appendix (RPKM 4.1) and 12 other tissues.

Summary

This gene encodes a protein that has a domain resembling seven transmembrane G protein-coupled hormone receptors (7TM receptors) at its C-terminus. The N-terminus of the encoded protein has six EGF-like modules, separated from the transmembrane segments by a serine/threonine-rich domain, a feature reminiscent of mucin-like, single-span, integral membrane glycoproteins with adhesive properties. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

ADGRE1 Products(5)

mRNA Protein Name
NM_001256252.2 NP_001243181.1 adhesion G protein-coupled receptor E1 isoform 2 precursor
NM_001256253.2 NP_001243182.1 adhesion G protein-coupled receptor E1 isoform 3 precursor
NM_001256254.2 NP_001243183.1 adhesion G protein-coupled receptor E1 isoform 4 precursor
NM_001256255.2 NP_001243184.1 adhesion G protein-coupled receptor E1 isoform 5 precursor
NM_001974.5 NP_001965.3 adhesion G protein-coupled receptor E1 isoform 1 precursor

ADGRE1 Protein Structure

EGF_CA

EGF_CA: Calcium-binding EGF domain (33 - 66)

EGF_CA

EGF_CA: Calcium-binding EGF domain (80 - 116)

EGF_CA

EGF_CA: Calcium-binding EGF domain (132 - 170)

EGF_CA

EGF_CA: Calcium-binding EGF domain (172 - 205)

EGF_CA

EGF_CA: Calcium-binding EGF domain (221 - 254)

EGF_CA

EGF_CA: Calcium-binding EGF domain (268 - 307)

GPS

GPS: GPCR proteolysis site, GPS, motif (548 - 591)

7tm_2

7tm_2: 7 transmembrane receptor (Secretin family) (601 - 840)

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  • 886 a.a.
Protein Preferred Names Protein Names

adhesion G protein-coupled receptor E1

EGF-like module receptor 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00349 ADGRE1 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus ADGRE1 VGNC VGNC:59630
Rattus norvegicus ADGRE1 RGD RGD:1359214
Mus musculus ADGRE1 MGD MGI:106912
Macaca mulatta ADGRE1 VGNC VGNC:69561
Canis familiaris ADGRE1 VGNC VGNC:37636