DENND6A - DENN domain containing 6A Gene

Also Known as AFI1A; FAM116A

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 201627

Summary

Enables guanyl-nucleotide exchange factor activity. Involved in positive regulation of cell-cell adhesion mediated by Cadherin. Located in recycling endosome. [provided by Alliance of Genome Resources, Jul 2025]
Ubiquitous expression in ovary (RPKM 8.9), thyroid (RPKM 8.0) and 25 other tissues.

DENND6A Products (1)

mRNA Protein Name
NM_152678.3 NP_689891.1 protein DENND6A

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables guanyl-nucleotide exchange factor activity IDA
IDA: Inferred from direct assay
22595670 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25852190 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of cell-cell adhesion mediated by cadherin IDA
IDA: Inferred from direct assay
22595670 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
22595670 GOA
located in recycling endosome IDA
IDA: Inferred from direct assay
22595670 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DENND6A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
DENND6A Q8IWF6 RPS6KC1 Homo sapiens Q96S38
Anti Tag CoIP
25852190
Intra
DENND6A Q8IWF6 RPS6KC1 Homo sapiens Q96S38
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03685 DENND1A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03688 DENND4A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03690 DENND5A Human Pre-designed siRNA Set A Pre-designed Set / Unkown