Srsf2 - serine and arginine-rich splicing factor 2 Gene

Also Known as SC35; MRF-1; Pr264; Sfrs2; Sfrs10; D11Wsu175e

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20382

Summary

The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding Other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. [provided by RefSeq, Sep 2010]

Srsf2 Products (1)

mRNA Protein Name
NM_011358.2 NP_035488.1 serine/arginine-rich splicing factor 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables pre-mRNA binding IDA
IDA: Inferred from direct assay
21470964 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11739632 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within regulation of alternative mRNA splicing, via spliceosome IDA
IDA: Inferred from direct assay
21470964 MGI
Cellular Component GO Annotation Evidence References Source
located in nuclear speck IDA
IDA: Inferred from direct assay
15564382 MGI
located in nucleus IDA
IDA: Inferred from direct assay
11641275 MGI
part of spliceosomal complex IDA
IDA: Inferred from direct assay
11827461 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

serine/arginine-rich splicing factor 2

  • myelin regulatory factor 1

  • putative myelin regulatory factor 1

  • splicing component, 35 kDa

  • splicing factor Sc35

  • splicing factor, arginine/serine-rich 2 (SC-35)

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13793 SRSF2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20106 Srsf2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26610 Srsf2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W278073 RNA splicing modulator 6 Modulator / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Srsf2 NCBI NCBI:6427