St6gal1 - beta galactoside alpha 2,6 sialyltransferase 1 Gene

Also Known as Siat1; St6gal; St6galI; St6Gal-I

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20440

Summary

This gene encodes a member of Glycosyltransferase family 29. The encoded protein is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The protein, which is normally found in the Golgi but can be proteolytically processed to a soluble form, is involved in the generation of the cell-surface carbohydrate determinants and differentiation antigens HB-6, CD75, and CD76. This gene has been incorrectly referred to as CD75. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on chromosome 15. [provided by RefSeq, Nov 2011]

St6gal1 Products (3)

mRNA Protein Name
NM_001252505.1 NP_001239434.1 beta-galactoside alpha-2,6-sialyltransferase 1
NM_001252506.1 NP_001239435.1 beta-galactoside alpha-2,6-sialyltransferase 1
NM_145933.4 NP_666045.1 beta-galactoside alpha-2,6-sialyltransferase 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables beta-galactoside alpha-2,6-sialyltransferase activity IDA
IDA: Inferred from direct assay
22039275 MGI
enables beta-galactoside alpha-2,6-sialyltransferase activity IMP
IMP: Inferred from mutant phenotype
12068010 MGI
enables sialyltransferase activity IDA
IDA: Inferred from direct assay
12966079 MGI
Biological Process GO Annotation Evidence References Source
involved in protein N-linked glycosylation via asparagine IDA
IDA: Inferred from direct assay
22039275 MGI
acts upstream of or within protein glycosylation IMP
IMP: Inferred from mutant phenotype
12068010 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

beta-galactoside alpha-2,6-sialyltransferase 1

  • CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 1

  • ST6Gal I

  • alpha 2,6-ST 1

Recombinant St6gal1 Proteins

Cat. No. Product Name Accession Purity
HY-P76094 ST6GAL1 Protein, Mouse (HEK293, His) Q64685 (K27-C403) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-173496 ST6GAL1-IN-1 Inhibitor 99.33% Unkown
HY-163548 SPP-002 Inhibitor 98.0% Unkown
HY-E70148 ST6 Gal Sialyltransferase 1 / Unkown
HY-RS17282 St6gal1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-172888 SPP-037 Inhibitor / Unkown
HY-179101 IAN-15B Inhibitor / Unkown
HY-RS13852 ST6GAL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23737 St6gal1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991369 EBU-141 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens St6gal1 NCBI NCBI:6480