Vps4b - vacuolar protein sorting 4B Gene

Also Known as Skd1; 8030489C12Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20479

Summary

Predicted to enable ATP hydrolysis activity; protein C-terminus binding activity; and protein homodimerization activity. Involved in late endosomal microautophagy; multivesicular body assembly; and viral budding from plasma membrane. Acts upstream of or within Cholesterol transport; endosome organization; and potassium ion transport. Located in cytosol. Orthologous to human VPS4B (vacuolar protein sorting 4 homolog B). [provided by Alliance of Genome Resources, Apr 2022]

Vps4b Products (1)

mRNA Protein Name
NM_009190.2 NP_033216.2 vacuolar protein sorting-associated protein 4B

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12594041 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within angiogenesis IMP
IMP: Inferred from mutant phenotype
28675177 MGI
acts upstream of or within canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
28675177 MGI
acts upstream of or within central nervous system development IMP
IMP: Inferred from mutant phenotype
28675177 MGI
acts upstream of or within cholesterol transport IMP
IMP: Inferred from mutant phenotype
10637304 MGI
acts upstream of or within endosome organization IGI
IGI: Inferred from genetic interaction
26720614 MGI
acts upstream of or within endosome organization IMP
IMP: Inferred from mutant phenotype
10637304 MGI
acts upstream of or within establishment of blood-brain barrier IMP
IMP: Inferred from mutant phenotype
28675177 MGI
involved in late endosomal microautophagy IMP
IMP: Inferred from mutant phenotype
21238931 MGI
involved in multivesicular body assembly IMP
IMP: Inferred from mutant phenotype
21238931 MGI
acts upstream of or within potassium ion transport IDA
IDA: Inferred from direct assay
8082782 MGI
acts upstream of or within vacuolar transport IMP
IMP: Inferred from mutant phenotype
28675177 MGI
involved in viral budding from plasma membrane IMP
IMP: Inferred from mutant phenotype
17940959 MGI
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
10637304 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

vacuolar protein sorting-associated protein 4B

  • suppressor of K(+) transport growth defect 1

  • suppressor of K+ transport defect 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-123872 MSC1094308 Inhibitor 99.63% Unkown
HY-RS15694 VPS4B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20516 Vps4b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27025 Vps4b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Vps4b NCBI NCBI:9525