Slc12a3 - solute carrier family 12, member 3 Gene

Also Known as NCC; TSC; NCCT

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20497

Summary

Enables sodium ion transmembrane transporter activity. Involved in sodium ion transport. Located in apical plasma membrane and cytosol. Is expressed in metanephros. Used to study Gitelman syndrome. Human ortholog(s) of this gene implicated in Gitelman syndrome and essential hypertension. Orthologous to human SLC12A3 (solute carrier family 12 member 3). [provided by Alliance of Genome Resources, Apr 2022]

Slc12a3 Products (2)

mRNA Protein Name
NM_001205311.1 NP_001192240.1 solute carrier family 12 member 3 isoform 1
NM_019415.2 NP_062288.2 solute carrier family 12 member 3 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Referencias Source
enables protein binding IPI
IPI: Inferred from physical interaction
26099046 MGI
enables sodium ion transmembrane transporter activity IDA
IDA: Inferred from direct assay
10516289 MGI
enables sodium:chloride symporter activity IDA
IDA: Inferred from direct assay
15068971 MGI
Biological Process GO Annotation Evidence Referencias Source
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
22846565 MGI
involved in response to aldosterone IDA
IDA: Inferred from direct assay
19690383 MGI
involved in response to dietary excess IDA
IDA: Inferred from direct assay
22846565 MGI
involved in signal transduction IMP
IMP: Inferred from mutant phenotype
22846565 MGI
involved in sodium ion transmembrane transport IDA
IDA: Inferred from direct assay
24026181 MGI
involved in sodium ion transport IMP
IMP: Inferred from mutant phenotype
10516289 MGI
Cellular Component GO Annotation Evidence Referencias Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
11423561 MGI
located in cytosol IDA
IDA: Inferred from direct assay
10516289 MGI
is active in plasma membrane IDA
IDA: Inferred from direct assay
36370249 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
10516289 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

solute carrier family 12 member 3

  • Na-Cl symporter

  • thiazide-sensitive sodium-chloride cotransporter

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Referencia número Nombre del producto
Efecto
Pureza
Rare Diseases
HY-B1477 Clopamide Inhibitor 99.0% Unkown
HY-RS12998 SLC12A3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18580 Slc12a3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25065 Slc12a3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc12a3 NCBI NCBI:6559