Slc16a1 - solute carrier family 16 (monocarboxylic acid transporters), member 1 Gene

Also Known as Mct1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20501

About Slc16a1

Chromosome 3: 104,545,984-104,565,778 forward strand.GRCm39:CM000996.3

This gene has 1 transcript (splice variant), 339 orthologues and 13 paralogues. Ubiquitous expression in colon adult (RPKM 55.3), placenta adult (RPKM 47.) and 27 other tissues.

Summary

Enables lactate transmembrane transporter activity. Involved in several processes, including behavioral response to nutrient; plasma membrane lactate transport; and regulation of Insulin secretion. Located in plasma membrane and synapse. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in familial hyperinsulinemic hypoglycemia 7. Orthologous to human SLC16A1 (solute carrier family 16 member 1). [provided by Alliance of Genome Resources, Apr 2022]

Slc16a1 Products (1)

mRNA Protein Name
NM_009196.4 NP_033222.1 monocarboxylate transporter 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables lactate transmembrane transporter activity IMP
IMP: Inferred from mutant phenotype
29026134 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
21792931 MGI
Biological Process GO Annotation Evidence References Source
involved in behavioral response to nutrient IMP
IMP: Inferred from mutant phenotype
24367518 MGI
involved in glucose homeostasis IMP
IMP: Inferred from mutant phenotype
22522610 MGI
involved in lipid metabolic process IMP
IMP: Inferred from mutant phenotype
24367518 MGI
involved in plasma membrane lactate transport IMP
IMP: Inferred from mutant phenotype
29026134 MGI
involved in pyruvate catabolic process IMP
IMP: Inferred from mutant phenotype
29026134 MGI
involved in regulation of insulin secretion IMP
IMP: Inferred from mutant phenotype
22522610 MGI
involved in response to food IMP
IMP: Inferred from mutant phenotype
24367518 MGI
Cellular Component GO Annotation Evidence References Source
is active in plasma membrane IDA
IDA: Inferred from direct assay
15037112 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
21792931 MGI
is active in synapse EXP
EXP: Inferred from Experiment
15572359 MGI
is active in synapse IDA
IDA: Inferred from direct assay
15572359 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Slc16a1 Protein Structure

2A0113

2A0113: TIGR00892 (0 - 465)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 493 a.a.
Protein Preferred Names Protein Names

monocarboxylate transporter 1

  • solute carrier family 16 member 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13016 SLC16A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-182416 slCeMM1 Inhibitor / Unkown
HY-RS13017 Slc16a1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13018 Slc16a1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc16a1 NCBI NCBI:6566