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Slc1a1 - solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 Gene

Also Known as EAAC1; EAAC2; EAAT3; MEAAC1; D130048G10Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 20510

Summary

Enables anion transmembrane transporter activity and identical protein binding activity. Involved in several processes, including cation transmembrane transport; learning or memory; and response to alkaloid. Acts upstream of or within several processes, including behavioral fear response; ion homeostasis; and regulation of cellular protein metabolic process. Located in several cellular components, including apical plasma membrane; endosome membrane; and membrane raft. Is integral component of plasma membrane. Is active in cytoplasm and dendrite. Is expressed in several structures, including alimentary system; eye; genitourinary system; integumental system; and nervous system. Used to study dicarboxylic aminoaciduria and low tension glaucoma. Human ortholog(s) of this gene implicated in dicarboxylic aminoaciduria and schizophrenia 18. Orthologous to human SLC1A1 (solute carrier family 1 member 1). [provided by Alliance of Genome Resources, Apr 2022]

Slc1a1 Products (1)

mRNA	Protein	Name
NM_009199.3	NP_033225.1	excitatory amino acid transporter 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables L-glutamate transmembrane transporter activity	IDA IDA: Inferred from direct assay	11030592	MGI
enables L-glutamate transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	14715943	MGI
enables cysteine transmembrane transporter activity	IDA IDA: Inferred from direct assay	12614333	MGI
enables glutamate:sodium symporter activity	IDA IDA: Inferred from direct assay	12119102	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	15009636	MGI
enables monoatomic anion channel activity	IDA IDA: Inferred from direct assay	15471567	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	16858406	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in G protein-coupled dopamine receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	28507136	MGI
acts upstream of or within L-glutamate import across plasma membrane	IDA IDA: Inferred from direct assay	11030592	MGI
acts upstream of or within L-glutamate import across plasma membrane	IMP IMP: Inferred from mutant phenotype	15140926	MGI
acts upstream of or within L-glutamate transmembrane transport	IDA IDA: Inferred from direct assay	15009636	MGI
acts upstream of or within activation of cysteine-type endopeptidase activity involved in apoptotic process	IDA IDA: Inferred from direct assay	16858406	MGI
acts upstream of or within activation of cysteine-type endopeptidase activity involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	16858406	MGI
involved in activation of protein kinase B activity	IMP IMP: Inferred from mutant phenotype	23827345	MGI
involved in adult behavior	IMP IMP: Inferred from mutant phenotype	28886095	MGI
acts upstream of or within behavioral fear response	IMP IMP: Inferred from mutant phenotype	22221107	MGI
acts upstream of or within blood vessel morphogenesis	IMP IMP: Inferred from mutant phenotype	25350110	MGI
involved in brain development	IMP IMP: Inferred from mutant phenotype	28886095	MGI
acts upstream of or within cellular response to ammonium ion	IDA IDA: Inferred from direct assay	24412196	MGI
acts upstream of or within cellular response to ammonium ion	IMP IMP: Inferred from mutant phenotype	24412196	MGI
acts upstream of or within cellular response to bisphenol A	IDA IDA: Inferred from direct assay	21980460	MGI
involved in cellular response to cocaine	IDA IDA: Inferred from direct assay	27208619	MGI
acts upstream of or within cellular response to mercury ion	IDA IDA: Inferred from direct assay	15635608	MGI
acts upstream of or within cellular response to oxidative stress	IMP IMP: Inferred from mutant phenotype	22732503	MGI
involved in conditioned place preference	IMP IMP: Inferred from mutant phenotype	28049029	MGI
involved in cysteine transmembrane transport	IDA IDA: Inferred from direct assay	30840898	MGI
involved in cytokine production	IMP IMP: Inferred from mutant phenotype	28886095	MGI
involved in cytokine-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	28886095	MGI
involved in dopamine metabolic process	IMP IMP: Inferred from mutant phenotype	28507136	MGI
acts upstream of or within establishment of protein localization	IMP IMP: Inferred from mutant phenotype	19923291	MGI
involved in gene expression	IMP IMP: Inferred from mutant phenotype	28507136	MGI
involved in glutamate receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	29229708	MGI
involved in glutathione biosynthetic process	IDA IDA: Inferred from direct assay	12614333	MGI
acts upstream of or within glutathione metabolic process	IMP IMP: Inferred from mutant phenotype	18799673	MGI
involved in glutathione metabolic process	IMP IMP: Inferred from mutant phenotype	28886095	MGI
involved in grooming behavior	IMP IMP: Inferred from mutant phenotype	28507136	MGI
acts upstream of or within heart contraction	IMP IMP: Inferred from mutant phenotype	23361868	MGI
acts upstream of or within intracellular glutamate homeostasis	IMP IMP: Inferred from mutant phenotype	19923291	MGI
acts upstream of or within intracellular zinc ion homeostasis	IMP IMP: Inferred from mutant phenotype	22575539	MGI
involved in intracellular zinc ion homeostasis	IMP IMP: Inferred from mutant phenotype	21084597	MGI
acts upstream of or within learning or memory	IMP IMP: Inferred from mutant phenotype	22221107	MGI
involved in locomotory behavior	IMP IMP: Inferred from mutant phenotype	28507136	MGI
acts upstream of or within long-term synaptic potentiation	IMP IMP: Inferred from mutant phenotype	19923291	MGI
involved in long-term synaptic potentiation	IMP IMP: Inferred from mutant phenotype	29229708	MGI
acts upstream of or within maintenance of blood-brain barrier	IMP IMP: Inferred from mutant phenotype	25350110	MGI
involved in memory	IMP IMP: Inferred from mutant phenotype	28886095	MGI
involved in motor behavior	IMP IMP: Inferred from mutant phenotype	28886095	MGI
acts upstream of or within motor neuron apoptotic process	IDA IDA: Inferred from direct assay	16858406	MGI
acts upstream of or within motor neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	16858406	MGI
involved in negative regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	29720605	MGI
involved in neurogenesis	IMP IMP: Inferred from mutant phenotype	29720605	MGI
involved in neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	27040821	MGI
acts upstream of or within neurotransmitter receptor transport to plasma membrane	IMP IMP: Inferred from mutant phenotype	24412196	MGI
acts upstream of or within peptidyl-serine phosphorylation	IMP IMP: Inferred from mutant phenotype	24412196	MGI
involved in positive regulation of heart rate	IMP IMP: Inferred from mutant phenotype	23361868	MGI
involved in postsynaptic modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	19923291	MGI
involved in postsynaptic modulation of chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	19923291	MGI
involved in regulation of heart rate	IMP IMP: Inferred from mutant phenotype	23361868	MGI
acts upstream of or within regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	24412196	MGI
acts upstream of or within regulation of protein targeting to membrane	IMP IMP: Inferred from mutant phenotype	24412196	MGI
involved in response to amphetamine	IMP IMP: Inferred from mutant phenotype	28507136	MGI
acts upstream of or within response to anesthetic	IMP IMP: Inferred from mutant phenotype	22221107	MGI
involved in response to anesthetic	IMP IMP: Inferred from mutant phenotype	23827345	MGI
acts upstream of or within response to axon injury	IDA IDA: Inferred from direct assay	16858406	MGI
acts upstream of or within response to axon injury	IMP IMP: Inferred from mutant phenotype	16858406	MGI
involved in response to axon injury	IMP IMP: Inferred from mutant phenotype	23827345	MGI
acts upstream of or within response to decreased oxygen levels	IMP IMP: Inferred from mutant phenotype	25350110	MGI
involved in response to decreased oxygen levels	IMP IMP: Inferred from mutant phenotype	29720605	MGI
involved in response to morphine	IDA IDA: Inferred from direct assay	28049029	MGI
involved in response to morphine	IMP IMP: Inferred from mutant phenotype	28049029	MGI
acts upstream of or within response to xenobiotic stimulus	IMP IMP: Inferred from mutant phenotype	20875840	MGI
involved in retina development in camera-type eye	IMP IMP: Inferred from mutant phenotype	28703795	MGI
acts upstream of or within retina layer formation	IMP IMP: Inferred from mutant phenotype	19766171	MGI
involved in retina layer formation	IMP IMP: Inferred from mutant phenotype	29677370	MGI
acts upstream of or within righting reflex	IMP IMP: Inferred from mutant phenotype	20875840	MGI
involved in superoxide metabolic process	IMP IMP: Inferred from mutant phenotype	27040821	MGI
involved in synapse organization	IMP IMP: Inferred from mutant phenotype	28886095	MGI
involved in zinc ion transmembrane transport	IMP IMP: Inferred from mutant phenotype	27040821	MGI

Cellular Component GO Annotation	Evidence	References	Source
is active in Schaffer collateral - CA1 synapse	IDA IDA: Inferred from direct assay	19923291	MGI
is active in Schaffer collateral - CA1 synapse	IMP IMP: Inferred from mutant phenotype	19923291	MGI
is active in apical plasma membrane	IDA IDA: Inferred from direct assay	26739563	MGI
is active in cell surface	IDA IDA: Inferred from direct assay	15009636	MGI
is active in cytoplasm	IDA IDA: Inferred from direct assay	20357106	MGI
is active in dendrite	IDA IDA: Inferred from direct assay	22539860	MGI
located in early endosome membrane	IDA IDA: Inferred from direct assay	30840898	MGI
located in membrane	IDA IDA: Inferred from direct assay	29350434	MGI
located in membrane raft	IDA IDA: Inferred from direct assay	15187084	MGI
is active in neuronal cell body	IDA IDA: Inferred from direct assay	22539860	MGI
is active in plasma membrane	IDA IDA: Inferred from direct assay	15471567	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	15009636	MGI
is active in plasma membrane	IPI IPI: Inferred from physical interaction	18799673	MGI
is active in recycling endosome	IDA IDA: Inferred from direct assay	20357106	MGI
located in recycling endosome membrane	IDA IDA: Inferred from direct assay	30840898	MGI
is active in synapse	IDA IDA: Inferred from direct assay	12710013	MGI
located in vesicle	IDA IDA: Inferred from direct assay	19364521	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
excitatory amino acid transporter 3	excitatory amino acid carrier 2 excitatory amino-acid carrier 1 glutamate transporter mEAAC2 sodium-dependent glutamate/aspartate transporter 3

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-130125	SLC1A1/EAAT3-IN-1	Inhibitor	98.63%	Unkown
HY-RS13050	SLC1A1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21933	Slc1a1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Slc1a1	NCBI	NCBI:6505