Slc1a2 - solute carrier family 1 (glial high affinity glutamate transporter), member 2 Gene

Also Known as GLT1; Eaat2; GLT-1; MGLT1; 1700091C19Rik; 2900019G14Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20511

About Slc1a2

Chromosome 2: 102,489,004-102,621,129 forward strand.GRCm39:CM000995.3

This gene has 12 transcripts (splice variants), 287 orthologues, 6 paralogues and is associated with 10 phenotypes. Biased expression in cortex adult (RPKM 172.), frontal lobe adult (RPKM 137.5) and 2 other tissues.

Summary

Enables cysteine transmembrane transporter activity and high-affinity glutamate transmembrane transporter activity. Involved in several processes, including L-glutamate import across plasma membrane; cellular response to cocaine; and glutathione biosynthetic process. Acts upstream of or within several processes, including L-glutamate transmembrane transport; positive regulation of glucose import; and visual behavior. Located in several cellular components, including astrocyte projection; axolemma; and membrane raft. Is integral component of plasma membrane. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and spinal cord. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 41. Orthologous to human SLC1A2 (solute carrier family 1 member 2). [provided by Alliance of Genome Resources, Apr 2022]

Slc1a2 Products (4)

mRNA Protein Name
NM_001361018.1 NP_001347947.1 excitatory amino acid transporter 2 isoform 4
NM_001077515.2 NP_001070983.1 excitatory amino acid transporter 2 isoform 2
NM_001077514.4 NP_001070982.1 excitatory amino acid transporter 2 isoform 1
NM_011393.2 NP_035523.1 excitatory amino acid transporter 2 isoform 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables L-glutamate transmembrane transporter activity IDA
IDA: Inferred from direct assay
24307171 MGI
enables L-glutamate transmembrane transporter activity IMP
IMP: Inferred from mutant phenotype
15009636 MGI
enables cysteine transmembrane transporter activity IDA
IDA: Inferred from direct assay
12614333 MGI
enables glutamate:sodium symporter activity IDA
IDA: Inferred from direct assay
7698742 MGI
enables high-affinity L-glutamate transmembrane transporter activity IDA
IDA: Inferred from direct assay
9373176 MGI
enables monoatomic anion transmembrane transporter activity IDA
IDA: Inferred from direct assay
24307171 MGI
Biological Process GO Annotation Evidence References Source
involved in L-glutamate import across plasma membrane IDA
IDA: Inferred from direct assay
9373176 MGI
acts upstream of or within L-glutamate import across plasma membrane IMP
IMP: Inferred from mutant phenotype
15140926 MGI
acts upstream of or within L-glutamate transmembrane transport IDA
IDA: Inferred from direct assay
7698742 MGI
acts upstream of or within L-glutamate transmembrane transport IMP
IMP: Inferred from mutant phenotype
15009636 MGI
acts upstream of or within adult behavior IMP
IMP: Inferred from mutant phenotype
9180080 MGI
involved in cellular response to cocaine IDA
IDA: Inferred from direct assay
27208619 MGI
acts upstream of or within cellular response to stimulus IMP
IMP: Inferred from mutant phenotype
16197522 MGI
involved in glutathione biosynthetic process IDA
IDA: Inferred from direct assay
12614333 MGI
acts upstream of or within monoatomic anion transmembrane transport IDA
IDA: Inferred from direct assay
24307171 MGI
acts upstream of or within multicellular organism growth IMP
IMP: Inferred from mutant phenotype
9180080 MGI
acts upstream of or within nervous system development IMP
IMP: Inferred from mutant phenotype
9180080 MGI
involved in neurotransmitter reuptake IDA
IDA: Inferred from direct assay
25834045 MGI
involved in neurotransmitter reuptake IMP
IMP: Inferred from mutant phenotype
25834045 MGI
acts upstream of or within positive regulation of D-glucose import IMP
IMP: Inferred from mutant phenotype
16197522 MGI
acts upstream of or within response to amino acid IMP
IMP: Inferred from mutant phenotype
9180080 MGI
acts upstream of or within response to light stimulus IMP
IMP: Inferred from mutant phenotype
9539795 MGI
acts upstream of or within response to wounding IMP
IMP: Inferred from mutant phenotype
9180080 MGI
acts upstream of or within response to xenobiotic stimulus IMP
IMP: Inferred from mutant phenotype
9180080 MGI
acts upstream of or within telencephalon development IMP
IMP: Inferred from mutant phenotype
9180080 MGI
acts upstream of or within visual behavior IMP
IMP: Inferred from mutant phenotype
16197522 MGI
Cellular Component GO Annotation Evidence References Source
located in astrocyte projection IDA
IDA: Inferred from direct assay
25716834 MGI
located in axolemma IDA
IDA: Inferred from direct assay
9671661 MGI
located in axon IDA
IDA: Inferred from direct assay
9671661 MGI
located in cell body IDA
IDA: Inferred from direct assay
25716834 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
25834045 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
25834045 MGI
located in membrane IDA
IDA: Inferred from direct assay
29350434 MGI
located in membrane raft IDA
IDA: Inferred from direct assay
15187084 MGI
located in membrane raft IGI
IGI: Inferred from genetic interaction
20193040 MGI
located in neuron projection terminus IDA
IDA: Inferred from direct assay
12558972 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
19364521 MGI
located in plasma membrane IMP
IMP: Inferred from mutant phenotype
9373176 MGI
located in synapse IDA
IDA: Inferred from direct assay
12558972 MGI
located in vesicle IDA
IDA: Inferred from direct assay
19364521 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Slc1a2 Protein Structure

SDF

SDF: pfam00375 (45 - 494)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 572 a.a.
Protein Preferred Names Protein Names

excitatory amino acid transporter 2

  • EAAT2 variant mEAAT2/5UT2

  • EAAT2 variant mEAAT2/5UT5

  • glutamate transporter 1c

  • sodium-dependent glutamatespartate transporter 2

  • solute carrier family 1, member 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13051 SLC1A2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13052 Slc1a2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13053 Slc1a2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc1a2 NCBI NCBI:6506