Slc1a3 - solute carrier family 1 (glial high affinity glutamate transporter), member 3 Gene

Also Known as Gmt1; Eaat1; GLAST; GLU-T; GluT-1; MGluT1; GLAST-1; B430115D02Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20512

Summary

Enables glutamate binding activity and high-affinity glutamate transmembrane transporter activity. Involved in D-aspartate import across plasma membrane and cellular response to cocaine. Acts upstream of or within several processes, including L-glutamate import across plasma membrane; gamma-aminobutyric acid biosynthetic process; and nervous system development. Located in several cellular components, including cell surface; neuron projection; and neuronal cell body. Is integral component of plasma membrane. Is expressed in several structures, including brain; connective tissue; eye; genitourinary system; and spinal cord. Used to study low tension glaucoma. Human ortholog(s) of this gene implicated in episodic ataxia type 6. Orthologous to human SLC1A3 (solute carrier family 1 member 3). [provided by Alliance of Genome Resources, Apr 2022]

Slc1a3 Products (1)

mRNA Protein Name
NM_148938.3 NP_683740.1 excitatory amino acid transporter 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables acidic amino acid transmembrane transporter activity IMP
IMP: Inferred from mutant phenotype
28032905 MGI
enables amino acid binding IDA
IDA: Inferred from direct assay
7903437 MGI
enables glutamate binding IDA
IDA: Inferred from direct assay
7903437 MGI
enables high-affinity L-glutamate transmembrane transporter activity IDA
IDA: Inferred from direct assay
7903437 MGI
enables high-affinity L-glutamate transmembrane transporter activity IMP
IMP: Inferred from mutant phenotype
15390100 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
14723703 MGI
Biological Process GO Annotation Evidence References Source
involved in D-aspartate import across plasma membrane IMP
IMP: Inferred from mutant phenotype
28032905 MGI
acts upstream of or within L-glutamate import IMP
IMP: Inferred from mutant phenotype
15390100 MGI
acts upstream of or within L-glutamate import across plasma membrane IMP
IMP: Inferred from mutant phenotype
15140926 MGI
acts upstream of or within L-glutamate transmembrane transport IDA
IDA: Inferred from direct assay
14723703 MGI
acts upstream of or within auditory behavior IMP
IMP: Inferred from mutant phenotype
11102482 MGI
acts upstream of or within cell morphogenesis involved in neuron differentiation IMP
IMP: Inferred from mutant phenotype
9753165 MGI
involved in cellular response to cocaine IDA
IDA: Inferred from direct assay
27208619 MGI
acts upstream of or within cranial nerve development IMP
IMP: Inferred from mutant phenotype
9753165 MGI
acts upstream of or within gamma-aminobutyric acid biosynthetic process IMP
IMP: Inferred from mutant phenotype
15305132 MGI
acts upstream of or within intracellular sodium ion homeostasis IMP
IMP: Inferred from mutant phenotype
19766171 MGI
acts upstream of or within neuromuscular process controlling balance IMP
IMP: Inferred from mutant phenotype
9753165 MGI
acts upstream of or within positive regulation of synaptic transmission IMP
IMP: Inferred from mutant phenotype
9539795 MGI
acts upstream of or within response to antibiotic IMP
IMP: Inferred from mutant phenotype
15862894 MGI
acts upstream of or within response to light stimulus IMP
IMP: Inferred from mutant phenotype
9539795 MGI
acts upstream of or within response to wounding IMP
IMP: Inferred from mutant phenotype
9753165 MGI
acts upstream of or within response to xenobiotic stimulus IMP
IMP: Inferred from mutant phenotype
9539795 MGI
acts upstream of or within sensory perception of sound IMP
IMP: Inferred from mutant phenotype
11102482 MGI
Cellular Component GO Annotation Evidence References Source
located in cell periphery IDA
IDA: Inferred from direct assay
20531390 MGI
located in cell projection IDA
IDA: Inferred from direct assay
9671661 MGI
located in cell surface IDA
IDA: Inferred from direct assay
14723703 MGI
located in neuron projection IDA
IDA: Inferred from direct assay
20531390 MGI
located in neuronal cell body IDA
IDA: Inferred from direct assay
9364068 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
14723703 MGI
located in synapse IDA
IDA: Inferred from direct assay
12558972 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

excitatory amino acid transporter 1

  • glial high affinity glutamate transporter

  • glutamate/aspartate transporter

  • high-affinity neuronal glutamate transporter

  • sodium-dependent glutamate/aspartate transporter 1

  • solute carrier family 1, member 3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13054 SLC1A3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19528 Slc1a3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26023 Slc1a3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc1a3 NCBI NCBI:6507