Slc22a1 - solute carrier family 22 (organic cation transporter), member 1 Gene

Also Known as Lx1; Oct1; Orct; Orct1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20517

Summary

Enables several functions, including pyrimidine nucleoside transmembrane transporter activity; toxin transmembrane transporter activity; and xenobiotic transmembrane transporter activity. Involved in toxin transport and xenobiotic transport. Acts upstream of or within cation transport. Located in apical plasma membrane. Is expressed in several structures, including adrenal gland; liver; mammary gland; metanephros; and nasal cavity mucosa. Orthologous to human SLC22A1 (solute carrier family 22 member 1). [provided by Alliance of Genome Resources, Apr 2022]

Slc22a1 Products (1)

mRNA Protein Name
NM_009202.5 NP_033228.2 solute carrier family 22 member 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables (R)-carnitine transmembrane transporter activity IDA
IDA: Inferred from direct assay
28942964 MGI
enables monoamine transmembrane transporter activity IDA
IDA: Inferred from direct assay
24961373 MGI
enables neurotransmitter transmembrane transporter activity IDA
IDA: Inferred from direct assay
24961373 MGI
enables organic cation transmembrane transporter activity IDA
IDA: Inferred from direct assay
12176030 MGI
enables pyrimidine nucleoside transmembrane transporter activity IMP
IMP: Inferred from mutant phenotype
20477935 MGI
enables quaternary ammonium group transmembrane transporter activity IDA
IDA: Inferred from direct assay
35469921 MGI
enables spermidine transmembrane transporter activity IDA
IDA: Inferred from direct assay
23458604 MGI
enables thiamine transmembrane transporter activity IDA
IDA: Inferred from direct assay
24961373 MGI
enables toxin transmembrane transporter activity IMP
IMP: Inferred from mutant phenotype
20477935 MGI
enables xenobiotic transmembrane transporter activity IDA
IDA: Inferred from direct assay
11463829 MGI
enables xenobiotic transmembrane transporter activity IMP
IMP: Inferred from mutant phenotype
20477935 MGI
Biological Process GO Annotation Evidence References Source
involved in (R)-carnitine transmembrane transport IDA
IDA: Inferred from direct assay
28942964 MGI
involved in acyl carnitine transmembrane transport IDA
IDA: Inferred from direct assay
28942964 MGI
involved in cellular detoxification IMP
IMP: Inferred from mutant phenotype
20477935 MGI
involved in dopamine transport IDA
IDA: Inferred from direct assay
35469921 MGI
involved in epinephrine transport IDA
IDA: Inferred from direct assay
35469921 MGI
involved in monoamine transport IDA
IDA: Inferred from direct assay
35469921 MGI
acts upstream of or within monoatomic cation transport IDA
IDA: Inferred from direct assay
12176030 MGI
involved in norepinephrine transport IDA
IDA: Inferred from direct assay
35469921 MGI
involved in serotonin transport IDA
IDA: Inferred from direct assay
24961373 MGI
involved in spermidine transport IDA
IDA: Inferred from direct assay
23458604 MGI
involved in thiamine transmembrane transport IDA
IDA: Inferred from direct assay
24961373 MGI
involved in xenobiotic transport IDA
IDA: Inferred from direct assay
11463829 MGI
involved in xenobiotic transport IMP
IMP: Inferred from mutant phenotype
20477935 MGI
Cellular Component GO Annotation Evidence References Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
20477935 MGI
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
28942964 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

solute carrier family 22 member 1

  • mOCT1

  • organic cation transporter 1

  • solute carrier family 22, member 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13061 SLC22A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19841 Slc22a1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26339 Slc22a1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc22a1 NCBI NCBI:6580