Slc22a12 - solute carrier family 22 (organic anion/cation transporter), member 12 Gene

Also Known as Rst; OAT4L; URAT1; Slc22al2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20521

About Slc22a12

Chromosome 19: 6,585,875-6,593,062 reverse strand.GRCm39:CM001012.3

This gene has 3 transcripts (splice variants), 475 orthologues, 26 paralogues and is associated with 5 phenotypes. Restricted expression toward kidney adult (RPKM 561.9).

Summary

Enables urate transmembrane transporter activity. Acts upstream of or within urate transport. Located in brush border membrane. Is integral component of membrane. Is expressed in central nervous system; dorsal root ganglion; male reproductive gland or organ; metanephros; and retina layer. Orthologous to human SLC22A12 (solute carrier family 22 member 12). [provided by Alliance of Genome Resources, Apr 2022]

Slc22a12 Products (1)

mRNA Protein Name
NM_009203.3 NP_033229.3 solute carrier family 22 member 12

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
14531806 MGI
enables urate transmembrane transporter activity IDA
IDA: Inferred from direct assay
14747372 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within urate transport IDA
IDA: Inferred from direct assay
14747372 MGI
involved in urate transport IDA
IDA: Inferred from direct assay
14747372 MGI
Cellular Component GO Annotation Evidence References Source
located in brush border membrane IDA
IDA: Inferred from direct assay
14747372 MGI
located in membrane IDA
IDA: Inferred from direct assay
14747372 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Slc22a12 Protein Structure

MFS_OAT

MFS_OAT: cd17374 (108 - 515)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 553 a.a.
Protein Preferred Names Protein Names

solute carrier family 22 member 12

  • renal-specific transporter

  • solute carrier family 22 (organic cation transporter)-like 2

  • urate anion exchanger 1

  • urate:anion antiporter SLC22A12

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-173231 hURAT1 inhibitor 2 Inhibitor / Unkown
HY-RS13063 SLC22A12 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13064 Slc22a12 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13065 Slc22a12 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc22a12 NCBI NCBI:116085