Slc9a1 - solute carrier family 9 (sodium/hydrogen exchanger), member 1 Gene

Also Known as swe; Apnh; Nhe1; Mir5122; mir-5122

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20544

Summary

Enables sodium:proton antiporter activity. Acts upstream of or within several processes, including regulation of pH; response to acidic pH; and sodium ion transport. Located in apical plasma membrane. Is expressed in several structures, including alimentary system; early conceptus; nervous system; oocyte; and sensory organ. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 19 and congestive heart failure. Orthologous to human SLC9A1 (solute carrier family 9 member A1). [provided by Alliance of Genome Resources, Apr 2022]

Slc9a1 Products (2)

mRNA Protein Name
NM_001358455.1 NP_001345384.1 sodium/hydrogen exchanger 1 isoform 2
NM_016981.3 NP_058677.1 sodium/hydrogen exchanger 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables sodium:proton antiporter activity IDA
IDA: Inferred from direct assay
10666043 MGI
enables sodium:proton antiporter activity IMP
IMP: Inferred from mutant phenotype
23677982 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cardiac muscle cell differentiation IMP
IMP: Inferred from mutant phenotype
19011045 MGI
acts upstream of or within embryo development IMP
IMP: Inferred from mutant phenotype
23677982 MGI
acts upstream of or within regulation of pH IDA
IDA: Inferred from direct assay
10666043 MGI
acts upstream of or within regulation of pH IMP
IMP: Inferred from mutant phenotype
10673550 MGI
acts upstream of or within response to acidic pH IMP
IMP: Inferred from mutant phenotype
10673550 MGI
acts upstream of or within sodium ion transport IDA
IDA: Inferred from direct assay
10666043 MGI
acts upstream of or within stem cell differentiation IMP
IMP: Inferred from mutant phenotype
19011045 MGI
Cellular Component GO Annotation Evidence References Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
21705333 MGI
located in membrane IDA
IDA: Inferred from direct assay
12619893 MGI
part of transporter complex IDA
IDA: Inferred from direct assay
23904602 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

sodium/hydrogen exchanger 1

  • NHE-1

  • Na(+)/H(+) exchanger 1

  • Na+/H+ antiporter

  • Na+/H+, amiloride sensitive

  • slow-wave epilepsy

  • solute carrier family 9, member 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13341 SLC9A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13349 SLC9B1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19075 Slc9a1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25566 Slc9a1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc9a1 NCBI NCBI:6548