Snai2 - snail family zinc finger 2 Gene

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and chromatin binding activity. Involved in several processes, including desmosome disassembly; mesenchyme development; and sensory perception of sound. Acts upstream of or within several processes, including animal organ morphogenesis; negative regulation of cell adhesion involved in substrate-bound cell migration; and negative regulation of extrinsic apoptotic signaling pathway in absence of ligand. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; embryo mesenchyme; and genitourinary system. Used to study Waardenburg syndrome type 2D. Human ortholog(s) of this gene implicated in Waardenburg syndrome type 2D and piebaldism. Orthologous to human SNAI2 (snail family transcriptional repressor 2). [provided by Alliance of Genome Resources, Apr 2022]