Smarcb1 - SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 Gene

Also Known as Ini1; Snf5; Baf47; SNF5/INI1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20587

Summary

Predicted to enable several functions, including Tat protein binding activity; p53 binding activity; and transcription coactivator activity. Predicted to contribute to RNA polymerase I core promoter sequence-specific DNA binding activity. Acts upstream of or within blastocyst hatching; cell differentiation; and negative regulation of cell population proliferation. Located in XY body and nucleus. Part of SWI/SNF complex; nBAF complex; and npBAF complex. Is expressed in several structures, including branchial arch; central nervous system; genitourinary system; limb primordium; and sensory organ. Used to study atypical teratoid rhabdoid tumor. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome 3; atypical teratoid rhabdoid tumor; neurilemmomatosis; and rhabdoid Cancer. Orthologous to human SMARCB1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1). [provided by Alliance of Genome Resources, Apr 2022]

Smarcb1 Products (2)

mRNA Protein Name
NM_001161853.1 NP_001155325.1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 isoform 2
NM_011418.2 NP_035548.1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16287714 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within blastocyst development IMP
IMP: Inferred from mutant phenotype
11263494 MGI
acts upstream of or within blastocyst hatching IMP
IMP: Inferred from mutant phenotype
11263494 MGI
acts upstream of or within hepatocyte differentiation IMP
IMP: Inferred from mutant phenotype
16138077 MGI
acts upstream of or within negative regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
11095756 MGI
Cellular Component GO Annotation Evidence References Source
part of SWI/SNF complex IDA
IDA: Inferred from direct assay
16287714 MGI
part of SWI/SNF superfamily-type complex IDA
IDA: Inferred from direct assay
12368262 MGI
located in XY body IDA
IDA: Inferred from direct assay
16787967 MGI
located in germ cell nucleus IDA
IDA: Inferred from direct assay
16787967 MGI
part of nBAF complex IDA
IDA: Inferred from direct assay
17640523 MGI
part of npBAF complex IDA
IDA: Inferred from direct assay
17640523 MGI
located in nucleus IDA
IDA: Inferred from direct assay
16787967 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

  • BRG1-associated factor 47

  • SNF5 homolog

  • integrase interactor 1 protein

  • mSNF5

Smarcb1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Smarcb1 Q9Z0H3 Smarcc1 Mus musculus P97496
Anti Tag CoIP
17255092
Intra
Smarcb1 Q9Z0H3 Smarcc1 Mus musculus P97496
Confocal
17255092
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-13803 Tazemetostat 99.93% Yes

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-145925B CFT8634 Inhibitor 98.10% Unkown
HY-131246 DM-01 Inhibitor 98.05% Unkown
HY-184266 GCLCi0 Inducer / Unkown
HY-184267 GCLCi1 / Unkown
HY-RS13409 SMARCB1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17520 Smarcb1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23976 Smarcb1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Smarcb1 NCBI NCBI:6598